Supercritical fluid impregnation of microcrystalline cellulose derived from the agricultural waste with ibuprofen

Krivokapić, Jovana; Ivanović, Jasna; Krkobabić, Mirjana; Arsenijević, Jelena; Ibrić, Svetlana

doi:10.1016/j.scp.2021.100447

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…In the field of polymeric processing, scCO2 can act as a plasticizer of semicrystalline and amorphous polymers and induce polymer foaming (16). ScCO2 technologies on a lab-scale in the pharmaceutical field are usually used for the processing of poorly water-soluble drugs to improve their properties (14,17) or for masking the unpleasant taste of drugs (18). Several scCO2-assisted processes were developed on an industrial scale for food and cosmetic applications.…”

Section: The Versatility Of Supercritical Carbon Dioxidementioning

confidence: 99%

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An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Milovanović¹,

Lukić²

2022

Arhiv za farmaciju

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Supercritical carbon dioxide (scCO2) application in the pharmaceutical industry is still undeveloped regardless of significant research interests in this processing medium shown in the last decades. ScCO2 technologies can improve drug solubility, bioavailability, and therapeutic effect. These technologies can lead to the development of new formulations that will contribute to a decrease in drug dose, medication frequency, and increase patients' well-being. Considering the significant decrease in the price of high-pressure equipment and society's growing need for cleaner production and safer products, it is expected that symbiosis between supercritical fluid and pharmaceutical technologies will happen soon. Therefore, this review was focused on the latest contributions of scCO2 technologies to the pharmaceutical field. The main aim was to bring these technologies closer to pharmaceutical specialists. For this purpose, the most commonly used technologies were explained and discussed: the preparation of solid dispersions, polymer impregnation with drugs, and drug micro/nanoparticle production using scCO2.

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Section: The Versatility Of Supercritical Carbon Dioxidementioning

confidence: 99%

“…The SSI process that employs scCO2 has attracted significant interest in a variety of research fields due to the compliance with the Green Chemistry rules, lack of organic solvent use, lower energy demands, and zero waste generation (17). Besides, when scCO2 acts as a polymer plasticizer, it facilitates impregnation.…”

Section: Impregnation Of Drugs Into Polymersmentioning

confidence: 99%

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Milovanović¹,

Lukić²

2022

Arhiv za farmaciju

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“…In recent years, the supercritical fluid technology, as a green technology, has received great attention from the academic community [1,2]. It has made great research progress in extraction, pharmacy, dyeing, foaming, spraying and other fields [3,4], and has been widely used in oil extraction [5]. Carbon dioxide is the most widely used solvent in supercritical fluid extraction technology because of its mild conditions, non-toxic, harmless, easy separation and no residue [6].…”

Section: Introductionmentioning

confidence: 99%

Molecular dynamics simulation of the interaction between palmitic acid and high pressure CO ₂

Li,

Sun,

et al. 2023

R. Soc. open sci.

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In this study, molecular dynamics simulation was used to explore the interaction characteristics of palmitic acid and CO 2 , and the effects of temperature and pressure on the solubility of palmitic acid in CO 2 were investigated. In the range of 293–353 K and 5–30 MPa, the snapshot of palmitic acid distribution in CO 2 shows that the molecular chain of palmitic acid in high-density CO 2 system is more straight and more dispersed than that in low-density CO 2 system. The radial distribution function further clearly shows that the solubility of palmitic acid in CO 2 decreases with the increase of temperature and increases with the increase of pressure, which is consistent with the fatty acid solubility data reported in the literature and the setting rules of supercritical CO 2 extraction process conditions. As the temperature decreases and the pressure increases, the interaction energy between palmitic acid and CO 2 increases, which is conducive to overcoming the intermolecular force of palmitic acid and promoting dissolution. The solubility parameters of palmitic acid and CO 2 can better reflect the trend of palmitic acid solubility changing with temperature and pressure, which can play a guiding role in the determination of process conditions and even the development of new processes.

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Biochemical and Thermochemical Conversion Technologies for Agriculture Waste Transformation

Durán-Valle,

López-Coca

2024

Waste as a Resource

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Supercritical fluid impregnation of microcrystalline cellulose derived from the agricultural waste with ibuprofen

Cited by 4 publications

References 32 publications

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Molecular dynamics simulation of the interaction between palmitic acid and high pressure CO ₂

Biochemical and Thermochemical Conversion Technologies for Agriculture Waste Transformation

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Supercritical fluid impregnation of microcrystalline cellulose derived from the agricultural waste with ibuprofen

Cited by 4 publications

References 32 publications

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Molecular dynamics simulation of the interaction between palmitic acid and high pressure CO 2

Biochemical and Thermochemical Conversion Technologies for Agriculture Waste Transformation

Contact Info

Product

Resources

About

Molecular dynamics simulation of the interaction between palmitic acid and high pressure CO ₂