Supercritical fluid extraction of paeonol from Cynanchum paniculatum (Bge.) Kitag. and subsequent isolation by high-speed counter-current chromatography coupled with high-performance liquid chromatography-photodiode array detector

Sun, Yinshi; Liu, Zhengbo; Wang, Jianhua; Tian, Wei; Zhou, Hongying; Zhu, Lixiang; Zhang, Chunyu

doi:10.1016/j.seppur.2008.10.007

Cited by 26 publications

(14 citation statements)

References 18 publications

(18 reference statements)

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“…For example, Lee et al [ 1 ] individually investigated organic solvents (conventional methods) and supercritical CO 2 to recover Artepillin C from the Brazilian propolis, and identified that the extracts obtained by SFE (45.3±0.10 mg/ml) showed the highest contents of the relevant compound (Soxhlet = 16.9±0.2 0mg/ml; Hot extraction = 16.4±0.23 mg/ml; Ultrasound = 16.0±0.06 mg/ml). Sun et al [ 100 ] extracted the active substance paeonol from Cynanchum paniculatum by SFE and other conventional techniques, identifying 72.02% of the active substance in the extracts obtained by SFE, a highly superior result to that found by other methods of extraction (ultrasound 1.56%, steam distillation 1.64% and Soxhlet 2.74%).…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil

et al. 2016

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The variations in the chemical composition, and consequently, on the biological activity of the propolis, are associated with its type and geographic origin. Considering this fact, this study evaluated propolis extracts obtained by supercritical extraction (SCO2) and ethanolic extraction (EtOH), in eight samples of different types of propolis (red, green and brown), collected from different regions in Brazil. The content of phenolic compounds, flavonoids, in vitro antioxidant activity (DPPH and ABTS), Artepillin C, p-coumaric acid and antimicrobial activity against two bacteria were determined for all extracts. For the EtOH extracts, the anti-proliferative activity regarding the cell lines of B16F10, were also evaluated. Amongst the samples evaluated, the red propolis from the Brazilian Northeast (states of Sergipe and Alagoas) showed the higher biological potential, as well as the larger content of antioxidant compounds. The best results were shown for the extracts obtained through the conventional extraction method (EtOH). However, the highest concentrations of Artepillin C and p-coumaric acid were identified in the extracts from SCO2, indicating a higher selectivity for the extraction of these compounds. It was verified that the composition and biological activity of the Brazilian propolis vary significantly, depending on the type of sample and geographical area of collection.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil

et al. 2016

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“…산해박(Cynanchum paniculatum)은 박주가리과(Asclepiadaceae)로 동아시아 지역에 주로 자생하는 다년초이다. 산해박의 주요 성분으로는 acetophenones, alkaloids 및 steroids 등으로 알려져 있으며, 약용식물로써 치통, 두드러 기, 류마티스 관절염 및 심와부 통증 등의 치료를 위해 전통적 으로 이용해 왔다 [17,18]…”

Section: 서 론unclassified

Acaricidal and antimicrobial toxicities of Cyanachum paniculatum root oils and these components against Haemaphysalis longicornis and human intestinal bacteria

Lee

Kim

Jeong

et al. 2018

JABC

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Anaerobic growth-inhibiting and acaricidal activities of 2'-hydroxy-5'-methoxyacetophenone derived from Cyanachum paniculatum oil and its derivatives against five intestinal bacteria (Bifidobacterium bifidum, B. longum, Clostridium pefringens, Escherichia coli and Lactobacillus casei) and Haemaphysalis longicornis were examined. In the packet test against the larvae of H. longicornis, none of the C. paniculatum oil exhibited acaricidal activity, while the C. paniculatum oil showed only antimicrobial activity against five intestinal bacteria in the disc diffusion method. Based on the inhibition zones and MIC values, 2',4'dimethoxyacetophenone, 2',5'-dimethoxyacetophenone, 2'-hydroxy-4'-methoxyacetophenone, 2'-hydroxy-5'-methoxyacetophenone, 2'-methoxyacetophenone, and 4'-methoxyacetophenone, containing a methyl group on the acetophenone skeleton, possessed growthinhibiting activities against C. perfringens and E. coli. However, acetophenone, 2'-hydroxyacetophenone, 4'-hydroxyacetophenone, 2',4'-hydroxyacetophenone and 2',5'-hydroxyacetophenone, which contained a hydroxyl group on the acetophenone skeleton, had no growth-inhibiting activity against intestinal bacteria. These results indicated that 2'-hydroxy-5'-methoxyacetophenone and its derivatives could potentially be developed as natural antimicrobial agents to specific control of C. perfringens and E. coli.

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“…It was difficult for ionic liquid to dissolve the larger size of sample, so that paeonol in sample was not effectively transferred into the suspension. Moreover, small particle size can increase mass transfer areas and decrease mass transfer resistance [1]. While the size was too small, the sample was easily conglomerated by the viscous ionic liquid solution [18], the residua and extract did not easily separate each other so that some paeonol extracted-out might remain in the residue.…”

Section: Resultsmentioning

confidence: 99%

“…Kitag. is widely used as traditional Chinese medicine and has been used for rheumatoid arthritis, traumatic injuries, urticaria, eczema and sedative [1]. Paeonol (Fig.…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquid-Assisted Extraction of Paeonol from Cynanchum paniculatum

Jin

Fan

2011

Chromatographia

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A new extraction technique, ionic liquid-assisted extraction (ILAE), has been developed. The ILAE process was further optimized by varying different parameters such as pretreatment time and temperature, ionic liquid/sample ratio, particle size and solvents. Under the optimum conditions, the extraction yield of ILAE was higher than that of Soxhlet extraction. The results of bioassay test showed that crude extract of ILAE was almost the same with that of Soxhlet extraction. The results in this study can serve as a reference for the ILAE of effective constituents in medicinal plants.

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Supercritical fluid extraction of paeonol from Cynanchum paniculatum (Bge.) Kitag. and subsequent isolation by high-speed counter-current chromatography coupled with high-performance liquid chromatography-photodiode array detector

Cited by 26 publications

References 18 publications

Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil

Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil

Acaricidal and antimicrobial toxicities of Cyanachum paniculatum root oils and these components against Haemaphysalis longicornis and human intestinal bacteria

Ionic Liquid-Assisted Extraction of Paeonol from Cynanchum paniculatum

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