Supercritical fluid extraction of isoflavones from soybean flour

Rostagno, Maurı́cio A.; Araújo, Júlio M.A.; Sandi, Delcio

doi:10.1016/s0308-8146(02)00106-1

Cited by 107 publications

(57 citation statements)

References 29 publications

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“…Some of the results were in the very good agreement with the data given in the literature [23]. Genistin was extracted well at both 20 MPa and 30 MPa (91% and 94%, respectively) while 20 MPa and 36 MPa were also recommended at 508C (80.3%).…”

Section: Extractability Of Isoflavones With Supercritical Fluidssupporting

confidence: 88%

“…The extraction efficiency is strongly dependent on mass transfer. Rostagno et al [23], who performed a supercritical fluid extraction of isoflavones from soy, applied a series of three 30-min extractions to each sample, i.e. the total extraction time was more than 90 min at a CO 2 flow rate of 1 mL(l) min -1 .…”

Section: Extractability Of Isoflavones With Supercritical Fluidsmentioning

confidence: 99%

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Supercritical fluid extraction of isoflavones from biological samples with ultra‐fast high‐performance liquid chromatography/mass spectrometry

Klejdus

Lojková

Lapčı́k

et al. 2005

J of Separation Science

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An efficient method of modifier addition for supercritical fluid extraction (SFE) of polar isoflavones was developed and yielded extraordinarily high recoveries. To find the optimal extraction conditions, a temperature and pressure optimization and modifier impact study was performed in naturally contaminated and spiked samples. Ultra-fast high-performance liquid chromatography/mass spectrometry (HPLC/MS) was used for the determination of isoflavones on an Atlantis dC18 high-speed reversed phase chromatographic column (20 x 2.1 mm, 3 microm particle size). A newly elaborated supercritical fluid extraction (SFE) procedure allowed more accurate (< 5%) and precise (< 4-7%) determination of isoflavones in biological materials. The HPLC/MS method significantly reduced analysis time with simultaneous improvement of sensitivity and detection limits. The on-column limits of detection LOD (S/N = 3) for isoflavone glycosides (daidzin, genistin, glycitin, ononin, and sissotrin) were 1.3-3.6 fmol and 0.2-1.0 fmol for aglycones (daidzein, glycitein, genistein, formononetin, and biochanin A), respectively.

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Section: Extractability Of Isoflavones With Supercritical Fluidssupporting

confidence: 88%

Section: Extractability Of Isoflavones With Supercritical Fluidsmentioning

confidence: 99%

Supercritical fluid extraction of isoflavones from biological samples with ultra‐fast high‐performance liquid chromatography/mass spectrometry

Klejdus

Lojková

Lapčı́k

et al. 2005

J of Separation Science

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“…SOX was carried out according to [1] for a period of nine hours in a medium containing 80% methanol. With the soybean flour sample, we also tested an equally long extraction in 100% methanol medium.…”

Section: Resultsmentioning

confidence: 99%

“…They also may be important antioxidants. Isoflavones have been implicated in a wide range of health conditions ranging from menopause to cardiovascular disease [1]. Isoflavonoids are substances that may prevent some types of cancer or osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Comparison of various extraction techniques for isolation and determination of isoflavonoids in plants

Bajer

Adam²,

Galla

et al. 2007

J of Separation Science

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In the present paper, the following extraction techniques have been used for extracting isoflavonoids from the species Matricaria recutita, Rosmarinus officinalis, Foeniculum vulgare, and Agrimonia eupatoria L.: supercritical fluid extraction (SFE), pressurized fluid extraction, matrix solid phase dispersion, ultrasonic extraction in an ultrasonic bath (USE) and by means of an ultrasonic homogeniser (HOM), extraction by means of Soxhlet apparatus (SOX), and solid phase extraction. Experimental optimization of all techniques has been carried out using a soybean flour. Subsequent analyses of the extracts were carried out by liquid chromatography with UV detection. The maximum yields of daidzein and genistein were obtained by extraction with the SOX, USE, and HOM techniques. The maximum yields of apigenin and biochanin A from herb samples were obtained by SFE.

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“…Supercritical fluid extraction (SFE) is an interesting alternative for the extraction of natural thermosensitive bioactive compounds that does not generate toxic residues due to its high selectivity, high extraction rate, and low critical point (Brunner, 2005;Herrero, Cifuentes, & Ibañez, 2006;Herrero, Mendiola, Cifuentes, & Ibáñez, 2010;Mchugh & Krukonis, 1994;Pereira & Meireles, 2010). Several reports describe successful applications of SFE of phenolic compounds from different samples (Casas et al, 2010;Rios & Gutiérrez-Rosales, 2010;Rostagno, Araújo, & Sandi, 2002). Recent works have studied alternative methods for obtaining polyphenols from pomegranate (Liu, Xu, Hao, & Gao, 2009;Rababah, Banat, Rababah, Ereifej, & Yang, 2010;Çam & Hişil, 2010).…”

mentioning

confidence: 99%

Supercritical Carbon Dioxide Extraction of Polyphenols from Pomegranate (Punica granatum L.) Leaves: Chemical Composition, Economic Evaluation and Chemometric Approach

Cavalcanti

Navarro-Díaz

Santos

et al. 2012

JFR

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The increasing demand for high-quality products and economically and environmentally friendly technologies, as well as restrictive legislative actions, has stimulated scientific research on the extraction, purification and identification of bioactive compounds from natural sources. Pomegranate (Punica granatum L.) is commonly used in traditional medicine due to its pharmacological properties, such as its anti-inflammatory, antihepatotoxicity, anti-lipoperoxidation, antidiabetic, anti-cancer and antimicrobial activities. The use of industrial residues as sources of bioactive compounds has emerged as an economically viable solution to the problem of solid waste treatment. In this context, this work aimed to evaluate the SC-CO 2 extraction of polyphenols from pomegranate leaves, evaluating the influence of temperature (40 and 50°C) and pressure (10-30 MPa) on extraction yield (EY), total phenolic content (TPC), antioxidant activity (AA) and the cost of manufacturing (COM) of the extracts. Principal component analysis (PCA) was used to reduce the dimensionality of multivariate data, making the visualization more straightforward and manageable. A high EY and TPC and low COM were obtained at the most effective operational conditions of 50°C and 30 MPa. The lack of correlation between EY-AA and TPC-AA indicated the coextraction of non-phenolic compounds. This assumption was corroborated by GC-MS analysis, which showed high levels of eicosanol, squalene, linoleic acid and tocols. Even though SC-CO 2 extraction resulted in a high TPC (257-389 mg.g -1 ) compared to the literature data, the low EY (0.21-0.67 %) and non-phenolic presence suggest that SC-CO 2 extraction may be a good purification pretreatment for the removal of non-polyphenolic compounds prior to further polyphenol extraction.

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Supercritical fluid extraction of isoflavones from soybean flour

Cited by 107 publications

References 29 publications

Supercritical fluid extraction of isoflavones from biological samples with ultra‐fast high‐performance liquid chromatography/mass spectrometry

Supercritical fluid extraction of isoflavones from biological samples with ultra‐fast high‐performance liquid chromatography/mass spectrometry

Comparison of various extraction techniques for isolation and determination of isoflavonoids in plants

Supercritical Carbon Dioxide Extraction of Polyphenols from Pomegranate (Punica granatum L.) Leaves: Chemical Composition, Economic Evaluation and Chemometric Approach

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