Supercritical fluid chromatography as a tool for enantioselective separation; A review

Effect of Buffer Constituents on Retention and Separation in Achiral and Chiral HPLC Systems with β-Cyclodextrin-Based Stationary Phase

“…Chiral selectors based on CDs became very popular for separation of stereoisomers in HPLC and also in CE, CEC, GC and SFC [1][2][3][4]. It is generally known that these cyclic oligosaccharides form inclusion complexes with a wide range of substances of suitable size and hydrophobicity.…”

Enantioselective potential of polysaccharide‐based chiral stationary phases in supercritical fluid chromatography

“…1,10 From this point of view, SFC offers benefits such as higher throughput or lower analysis times than the conventional high-performance liquid chromatography (HPLC) technique. 1,[11][12][13] On the market, there are a number of chiral stationary phases (CSPs) including many of HPLC CSPs, that are suitable for enantioseparation in SFC. Regarding HPLC as well as SFC enantioseparations, polysaccharide-based CSPs are classified as the versatile ones and are extensively used.…”

Curcumin-loaded solid lipid particles by PGSS technology

“…Carbon dioxide (CO 2 ) is a non-toxic and non-inflammable fluid and possesses a relatively low critical temperature and pressure. CO 2 is the gas of choice for supercritical processes, including chromatographic methods for enantioselective separation [18,19], chemical extraction from natural sources [20], pharmaceutical and cosmetic tailoring [21], food processing [22], as well as for processing of pharmaceuticals that can be degraded under harsh conditions. Furthermore, depending on the nature of the biologically active compound, supercritical CO 2 can be used as solvent, anti-solvent or solute [23,24].…”