Supercritical extraction of neolignans from Piper regnelli var. pallescens

Lemos, Caroline Ortega Terra; Garcia, Vitor Augusto dos Santos; Gonçalves, Renata Menoci; Leal, Ivana Corrêa Ramos; Siqueira, Vera Lúcia Dias; Cardozo‐Filho, Lúcio; Cabral, Vladimir Ferreira

doi:10.1016/j.supflu.2012.07.003

Cited by 21 publications

(15 citation statements)

References 25 publications

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“…A utilização de menores pressões aumentam a seletividade, como já havia sido descrito em pesquisas anteriores, visto que o aumento da densidade pode aumentar a solubilidade com outros componentes (Lemos et al, 2012). É possível confirmar esta hipótese observando os rendimentos da extração 7, que apresenta um maior rendimento de massa, no entanto, apresenta uma baixa seletividade (3,96% de cumarina no extrato).…”

Section: Rendimento Em Termos De Porcentagem De Cumarinaunclassified

Extração Supercrítica Com Utilização De Modificadores E Caracterização a Partir Da Semente De Cumaru (Dipteryx Odorata)

Lima¹,

Ferreira-Pinto²,

Giufrida³

et al. 2015

Anais Do XX Congresso Brasileiro De Engenharia Química

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RESUMO -Este trabalho tem como objetivo a extração e quantificação de compostos bioativos da semente do cumaru por meio de extração convencional (soxhlet) e supercrítica utilizando dióxido de carbono e solventes modificadores. As extrações supercríticas foram realizadas numa faixa de pressão de 180 -220 bar e temperatura de 60 -80ºC. O planejamento experimental foi definido a partir do design fatorial fracionado (método Taguchi). Os extratos foram analisados por cromatografia liquida (HPLC) e gasosa com espectrofotômetro de massas (GC-MS). A extração da cumarina utilizando o dióxido de carbono e modificados apresentou melhor seletividade e rendimentos em relação à extração convencional.

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Section: Rendimento Em Termos De Porcentagem De Cumarinaunclassified

Extração Supercrítica Com Utilização De Modificadores E Caracterização a Partir Da Semente De Cumaru (Dipteryx Odorata)

Lima¹,

Ferreira-Pinto²,

Giufrida³

et al. 2015

Anais Do XX Congresso Brasileiro De Engenharia Química

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“…After reaching the pressure, the system was left at equilibrium by 30 min and the extractions were performed by 120 min. These set parameters were based on previous works for isolation of terpenoid compounds (Lemos et al, 2012). This procedure originated five different samples that were obtained from different pressures and temperatures conditions, as we can see in Table I.…”

Section: Supercritical Fluid (Sf)mentioning

confidence: 99%

“…Different kinds of triterpenes are correlated to anti-cancer activities, such as the pentacyclic skeletons (de Almeida et al, 2013;Hao et al, 2013). Moreover, the research for new anti-cancer drugs shows that natural pentacyclic triterpenes rarely exhibit severe side effects (Lemos et al, 2012). However, for extracting and isolating different secondary metabolites, including triterpenes, it is hardly necessary to use large amounts of solvents, especially by the conventional extraction methodologies, such as Soxhlet and maceration.…”

Section: Introductionmentioning

confidence: 99%

Passiflora mucronata leaves extracts obtained from different methodologies: a phytochemical study based on cytotoxic and apoptosis activities of triterpenes and phytosterols constituents

Silva

Oliveira

Barbosa

et al. 2020

Braz. J. Pharm. Sci.

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Cancer is one of the most prevalent diseases worldwide and the natural products could be a source of bioactive compounds. Passiflora mucronata (PM) belongs to a very known vegetal genus, although, there are no studies about cytotoxic activity or isolated compounds. Different extracts from PM were obtained by liquid-liquid partition (P), Soxhlet (Sox) and supercritical fluid (SFE1-5) extraction techniques, being compared concerning their yields, chemical profile and cytotoxicity. The Sox extracts showed the highest yields (6.03%: hexane; 2.51%: dichloromethane) followed by SFE (from 4.34 to 1.63%) and partitions (1.06 and 2.26%). The hexane partition (HP) showed the best cytotoxic activity against K562 cell line (IC 50 = 18.72 µg.mL-1). From HP, the following compounds were identified and analysed its cytotoxic activities: β-amyrin (IC 50 = 3.92 µg.mL-1), β-sitosterol (IC 50 = 3.37 µg.mL-1), stigmasterol (IC 50 = 3.31 µg.mL-1) and oleanolic acid. Stigmasterol induced about 75% of K562 total apoptosis. The compounds were tested against MA-104 cell line and the selective index (SI) attributed (SI >10 for all compounds). This indicates good selectivity to K562 cell line at the expense of MA-104. This is the first time, identifying those compounds to PM .

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“…The extraction experiments with supercritical fluid were conducted in a laboratory scale unit as in earlier studies (Lemos et al, 2012, Santos et al, 2015. The unit consists of a reservoir of solvent (CO 2, White Martins SA, with 99.9 % purity), one syringe pump (Isco model 500D), two thermostatic baths (Julabo F25-ME and Quimis Q214M2) and a stainless steel extractor 17 cm long with an internal diameter of 2.85 cm.…”

Section: Supercritical Fluid Extraction (Sfe)mentioning

confidence: 99%

EXTRACTION OF BIOACTIVE COMPOUNDS OF LEAVES OF Duguetia furfuracea (ANNONACEAE) USING GREEN AND ORGANIC SOLVENTS

Favareto

Teixeira

Soares

et al. 2019

Braz. J. Chem. Eng.

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Duguetia furfuracea (Annonaceae) is a shrub found in the Brazilian Cerrado that is used in popular medicine as an antirheumatic, for wound healing, treatment of kidney pain and against pediculosis. The aim of this study was to analyze the extraction of leaves of Duguetia furfuracea, using supercritical CO 2 , ethanol and hexane as solvents. For the supercritical extraction, an experimental planning 2 3 with triplicates of the central point was used to evaluate the effects of temperature (313-333 K), pressure (15-23 MPa) and volumetric flow rate (3-6 mL min -1 ) on the extraction yield, total phenolic content and antioxidant activity compared with extracts obtained by Soxhlet extraction. The effects of the variables on the extraction yield were positive and the pressure had greater influence. However, the highest performances, total phenolic content and antioxidant activities were obtained by the Soxhlet method. The mathematical model based on the Brunauer-Emmett-Teller theory of adsorption correlated satisfactorily the experimental values of the supercritical extraction.

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Supercritical extraction of neolignans from Piper regnelli var. pallescens

Cited by 21 publications

References 25 publications

Extração Supercrítica Com Utilização De Modificadores E Caracterização a Partir Da Semente De Cumaru (Dipteryx Odorata)

Extração Supercrítica Com Utilização De Modificadores E Caracterização a Partir Da Semente De Cumaru (Dipteryx Odorata)

Passiflora mucronata leaves extracts obtained from different methodologies: a phytochemical study based on cytotoxic and apoptosis activities of triterpenes and phytosterols constituents

EXTRACTION OF BIOACTIVE COMPOUNDS OF LEAVES OF Duguetia furfuracea (ANNONACEAE) USING GREEN AND ORGANIC SOLVENTS

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