Supercritical-CO2 Foam Extrusion of Hydroxypropyl Methyl Cellulose Acetate Succinate/Itraconazole Amorphous Solid Dispersions: Processing-Structure-Property Relations

Rahimi, Shahab Kashani; O’Donnell, K. P.; Haight, Brian; Machado, Augie; Martin, Charlie; Meng, Fan; Listro, Tony; Zhang, Feng

doi:10.1016/j.xphs.2020.11.038

Cited by 7 publications

(2 citation statements)

References 42 publications

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“…These new technologies have many advantages compared with traditional SD processes. For example, the hot melt extrusion technique has the advantage of flexibility in process design, short process residence times, and is environmentally safe, as no organic solvents are employed during the process [ 84 ]. In addition, supercritical fluid technology, spray-drying technology, and micro-environment pH control technique did not require the high temperatures and more chemical solvents that are used in traditional processes.…”

Section: The Methods Of Solubilizationmentioning

confidence: 99%

Biological Activities and Solubilization Methodologies of Naringin

Jiang

Zhang

Lin

et al. 2023

Foods

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Naringin (NG), a natural flavanone glycoside, possesses a multitude of pharmacological properties, encompassing anti-inflammatory, sedative, antioxidant, anticancer, anti-osteoporosis, and lipid-lowering functions, and serves as a facilitator for the absorption of other drugs. Despite these powerful qualities, NG’s limited solubility and bioavailability primarily undermine its therapeutic potential. Consequently, innovative solubilization methodologies have received considerable attention, propelling a surge of scholarly investigation in this arena. Among the most promising solutions is the enhancement of NG’s solubility and physiological activity without compromising its inherent active structure, therefore enabling the formulation of non-toxic and benign human body preparations. This article delivers a comprehensive overview of NG and its physiological activities, particularly emphasizing the impacts of structural modification, solid dispersions (SDs), inclusion compound, polymeric micelle, liposomes, and nanoparticles on NG solubilization. By synthesizing current research, this research elucidates the bioavailability of NG, broadens its clinical applicability, and paves the way for further exploration and expansion of its application spectrum.

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Section: The Methods Of Solubilizationmentioning

confidence: 99%

Biological Activities and Solubilization Methodologies of Naringin

Jiang

Zhang

Lin

et al. 2023

Foods

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“…Many foam manufacturing methods has been studied both commercially and scientifically. The well-known methods can be named specifically, extrusion 38 , injection molding 39 and batch process 40 , melting the raw materials under high temperature and providing the formation of highly porous final product (foam) using foaming agents 41 . Although the production time is very short with these techniques, they do not allow pre-surface modification.…”

Section: Introductionmentioning

confidence: 99%

A Study on Physical, Morphological and Antibacterial Properties of Bio Polymers Reinforced Polyvinyl Acetate Foams

Yıldırım

Özen

Ergün³

et al. 2022

Mat. Res.

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In this study, foaming-agent free novel polyvinyl acetate (PVAc) foams reinforced with bio polymers were manufactured through freeze-drying technique. The physical, morphological and antibacterial properties of foams which were reinforced with different ratio of zinc borate and water-soluble chitosan were investigated according to relevant standards. The PVAc foams showed low densities (0.12 g/cm 3 -0.21 g/cm 3 ) and high porosity rates (87.50% -79.05%). The results showed that although the foams have no antibacterial character against Escherichia Coli, they have antibacterial character against Staphylococcus Aureus bacteria. This study mainly focusses on physical and morphological properties of the foams. However, researchers also performed accelerated weathering tests to determine its usability in different industries. The effects of accelerated weathering on the surface of foams were investigated by measuring surface color. The highest color difference was determined 8.09. This foam can be used as a low-density packaging material and/or medical box with its promising physical and morphological properties with hazardous-chemical free structure.

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The effect of in‐situ fibrillated polytetrafluoroethylene on the rheological, mechanical, and foaming properties of polystyrene based nanocomposite foams

Zhou,

Chen,

Huang

2024

Journal of Polymer Science

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Polystyrene/polytetrafluoroethylene (PS/PTFE) in‐situ fibrillated nanocomposites were prepared by melt blending using a HAAKE torque rheometer, and the effects of different contents of in‐situ nanofibrillated PTFE on the properties of PS/PTFE nanocomposites were studied. The results showed that PTFE was in‐situ nanofibrillation in the composites, and the toughness, energy storage modulus and complex viscosity of PS/PTFE nanocomposite are all improved. When the content of PTFE was 3 wt%, the elongation at break was the highest, which was three times that of neat PS. What is more, the addition of PTFE significantly improved the cell morphology of PS/PTFE nanocomposite foams by supercritical fluid foaming. The cell structure and morphology of PS/PTFE (3 wt%) nanocomposite foam was the best under 110°C foaming temperature, and the cell diameter and cell density were 3.27 μm and 1.11 × 1010 cells/cm3, respectively. In addition, the tensile strength of PS/PTFE nanocomposite foams increased from 35.4 MPa of neat PS foam to 39.6 MPa of PS/PTFE (3 wt%) foam.

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Supercritical-CO2 Foam Extrusion of Hydroxypropyl Methyl Cellulose Acetate Succinate/Itraconazole Amorphous Solid Dispersions: Processing-Structure-Property Relations

Cited by 7 publications

References 42 publications

Biological Activities and Solubilization Methodologies of Naringin

Biological Activities and Solubilization Methodologies of Naringin

A Study on Physical, Morphological and Antibacterial Properties of Bio Polymers Reinforced Polyvinyl Acetate Foams

The effect of in‐situ fibrillated polytetrafluoroethylene on the rheological, mechanical, and foaming properties of polystyrene based nanocomposite foams

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