Supercritical CO2 extraction of γ-linolenic acid and other lipids from Arthrospira (Spirulina)maxima: Comparison with organic solvent extraction

Mendes, Rui L.; Reis, Alberto; Palavra, A. M. F.

doi:10.1016/j.foodchem.2005.07.019

Cited by 129 publications

(99 citation statements)

References 11 publications

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“…These findings agree with those of Mendes et al 4 who reported that an increase in pressure and temperature had a positive effect on the extraction of GLA. In addition, raising the temperature from 100 °C to 120 °C increases the yield of extracted saturated and unsaturated fatty acids, and especially that of GLA 21 .…”

Section: Extraction Temperaturesupporting

confidence: 93%

“…Spirulina can produce a large number of valuable compounds such as phycocyanin and carotenoids used as antioxidants 1,2 , and polyunsaturated fatty acids such as linoleic acid and γ-linolenic acid (GLA) 3 . Polyunsaturated fatty acids have an important role in human metabolic pathways, particularly as precursors of a particular type of prostaglandin E1 4 . GLA has been used in several medical applications such as in the treatment of dermatitis, diabetes, and pre-menstrual syndrome 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…and Mortierella spp.) 8 , evening primrose seeds 9 , borage seed 10 and Spirulina 4,11 . The lipid extraction yield depends on the nature of the solvent, the lipid or oil particle size, the samplesolvent ratio, temperature, and time of extraction.…”

Section: Introductionmentioning

confidence: 99%

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Chaiklahan¹,

Chirasuwan²,

Loha³

et al. 2008

ScienceAsia

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Lipid extraction from Spirulina using a single stage extraction at 30 °C showed that a sample-solvent ratio of 1:10 and an extraction time of 120 min gave the highest total fatty acid (TFA) yield, whereas a ratio of 1:5 was suitable for a multistage extraction. An increase in extraction temperature resulted in higher lipid and TFA yields. Increasing the extraction temperature from 30 °C to 60 °C decreased the extraction time and increased the yield of lipid and TFA in the solvent by approximately 69% and 55%, respectively. In order to increase the extraction yield of the lipid and TFA, multistage cross-current extraction was implemented. Seven-stage extraction at 30 °C resulted in 85% TFA recovery, whereas only a three-stage extraction was needed to obtain the same level of TFA at 60 °C. Lipid extracted from Spirulina contained approximately 21% linoleic acid and 18% γ-linolenic acid.

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Section: Extraction Temperaturesupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Chaiklahan¹,

Chirasuwan²,

Loha³

et al. 2008

ScienceAsia

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“…Supercritical CO 2 extraction efficiency is affected by four main factors: pressure, temperature, CO 2 flow rate, and extraction time. Ethanol (10 -15%), co-solvent, lead to similar results of Bligh and Hyer method at extracting oil from Arthrospira maxima and Spirulina platensis (Mendes, Reis et al 2006;Sajilata, Singhal et al 2008). The limitation of supercritical fluid extraction is high capital cost and high cost for maintainence.…”

Section: Supercritical Fluid Extractionmentioning

confidence: 73%

Microbial Biodiesel Production - Oil Feedstocks Produced from Microbial Cell Cultivations

Zhang¹,

Hu²

2011

Biodiesel - Feedstocks and Processing Technologies

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“…Besides its role in the thylakoid membrane, SQDG is an attractive compound for development of new drugs because of its extensive biological activities which include inhibitory effects on DNA polymerase and HIV-reverse transcriptase, P-selectin receptors, the AIDS virus, telomerase, and inflammation/proliferation [11][12][13][14][15][16] . Cyanobacterium, Spirulina platensis, is a rich source of valuable compounds such as the antioxidant phycocyanin and polyunsaturated fatty acids (linoleic acid and gamma-linolenic acid) which have an important role in human metabolic pathways, particularly as a precursor of one kind of prostaglandin 17,18 . Hayashi et al 19 were the first to report the anti HSV-1 activity of aqueous extracts from S. platensis.…”

Section: Introductionmentioning

confidence: 99%

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Chirasuwan¹,

Chaiklahan²,

Kittakoop³

et al. 2009

ScienceAsia

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Herpes simplex virus type 1 (HSV-1) causes a variety of infections in humans and can be found in many countries worldwide. Although the antiherpes drug, acyclovir, has been used very successfully, an acyclovir-resistant strain of HSV has recently been found in patients and drug toxicity has been reported with increasing use of it. As a potential alternative, it has been found that both a water soluble and a lipid extract of the microalga Spirulina platensis exhibit antiviral activity (HSV-1) in Vero cells. In this study, bioassay guided fractionation of a lipid extract from S. platensis led to the identification of sulphoquinovosyl diacylglycerol as the active antiviral agent. The chemical structure of this compound was confirmed by NMR and LC-mass spectroscopic analyses. Results from the study showed that the compound exhibited a remarkable activity against HSV-1 with an IC50 value of 6.8 µg/ml, which was comparable to that of acyclovir (1.5 µg/ml).

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Supercritical CO2 extraction of γ-linolenic acid and other lipids from Arthrospira (Spirulina)maxima: Comparison with organic solvent extraction

Cited by 129 publications

References 11 publications

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Microbial Biodiesel Production - Oil Feedstocks Produced from Microbial Cell Cultivations

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