Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release

Milovanović, Stoja; Marković, Darka; Mraković, Ana; Kuska, Robert; Žižović, Irena; Frerich, Sulamith; Ivanović, Jasna

doi:10.1016/j.msec.2019.01.106

Cited by 81 publications

(79 citation statements)

References 62 publications

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“…The release profile and the amount of thymol released depend on the carrier’s morphology, thymol loading, nature of the medium, and its solubility in the medium and carrier material. The released amount of thymol in distilled water from poly(d,l-lactic-co-glycolic acid) (PLGA) with 6.62% loading was around 4.8 mg/g after 24 h [ 64 ]. In another study [ 21 ], the sample of cellulose acetate with the highest thymol loading (63.84%) reached the highest value of released thymol of around 400 mg/g.…”

Section: Resultsmentioning

confidence: 99%

Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties

et al. 2020

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In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material. Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent. Experiments were performed at 35 °C, pressures of 15.5 and 30 MPa, and an impregnation time in the range of 4–24 h. The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively. The addition of natural zeolite (15–60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7–27.3%. FTIR and SEM analyses were applied for the characterization of the films. Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well. Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model. SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).

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Section: Resultsmentioning

confidence: 99%

Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties

et al. 2020

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“…The application of supercritical carbon dioxide (scCO 2 ) as a solvent to this process brings several advantages, including processing at moderately low temperatures, and the fact that scCO 2 acts as a molecular lubricant and induces polymer swelling and foam formation [268]. By controlling the temperature or pressure during foaming with scCO 2 , it is also possible to tune the crystalline structure through the controlling of PLA and therefore its properties [269].…”

Section: Polylactic Acidmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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“…The process was optimized for each polymer to obtain stable microcellular foams upon the system decompression. The highest thymol loading (6.62%) was obtained for the copolymer PLGA, whereby the sample exhibited controlled thymol release within 72 h in media having pH values from 1.1 to 7.4 [96].…”

Section: Supercritical Foamingmentioning

confidence: 97%

“…Milovanovic et al [96] prepared foams loaded with thymol in a one-step SSI-foaming process from amorphous, medical grade poly(D,L-lactic acid) (PLA), and poly(D,L-lactic-co-glycolic acid) (PLGA). The impregnation performed with different CO 2 densities (273-815 kg/m3) and short processing times (2 and 4 h) enabled thymol loading of 0.92-6.62%.…”

Section: Supercritical Foamingmentioning

confidence: 99%

Supercritical Fluid Applications in the Design of Novel Antimicrobial Materials

Žižović

2020

Molecules

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Bacterial resistance to antibiotics is one of the biggest problems in the modern world. The prevention of bacterial spreading from hospitals to the community and vice versa is an issue we have to deal with. This review presents a vast potential of contemporary high-pressure techniques in the design of materials with antimicrobial activity. Scientists from all over the world came up with ideas on how to exploit extraordinary properties of supercritical fluids in the production of advantageous materials in an environmentally friendly way. The review summarizes reported methods and results.

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Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release

Cited by 81 publications

References 62 publications

Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties

Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties

Recent Advances in Bioplastics: Application and Biodegradation

Supercritical Fluid Applications in the Design of Novel Antimicrobial Materials

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