Supercritical CO2-assisted impregnation/deposition of polymeric materials with pharmaceutical, nutraceutical, and biomedical applications: A review (2015–2021)

Machado, Noelia D.; Mosquera, José E.; Martini, Raquel E.; Goñi, María L.; Gañán, Nicolás Alberto

doi:10.1016/j.supflu.2022.105763

Cited by 13 publications

(8 citation statements)

References 156 publications

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“…Both methods are influenced by temperature, CO 2 pressure, secondary phases, soaking time, presence of cosolvents, and depressurization rate, among the most relevant [ 99 , 100 ].…”

Section: The Bioactivation Of the Scaffolds Through Incorporation Of ...mentioning

confidence: 99%

“…On the contrary, for a system with strong polymer/drug interactions, a slow depressurization rate should be chosen [ 99 ]. On the other hand, Machado et al [ 100 ] recently reported that rapid depressurization generally induces excessive solute losses, especially if the drug–polymer affinity is low. In this sense, most of the reviewed works selected low decompression rates.…”

Section: The Bioactivation Of the Scaffolds Through Incorporation Of ...mentioning

confidence: 99%

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Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming

Fanovich,

Di Maio,

Salerno

2023

JFB

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Biocompatible and biodegradable foams prepared using the high-pressure foaming technique have been widely investigated in recent decades as porous scaffolds for in vitro and in vivo tissue growth. In fact, the foaming process can operate at low temperatures to load bioactive molecules and cells within the pores of the scaffold, while the density and pore architecture, and, hence, properties of the scaffold, can be finely modulated by the proper selection of materials and processing conditions. Most importantly, the high-pressure foaming of polymers is an ideal choice to limit and/or avoid the use of cytotoxic and tissue-toxic compounds during scaffold preparation. The aim of this review is to provide the reader with the state of the art and current trend in the high-pressure foaming of biomedical polymers and composites towards the design and fabrication of multifunctional scaffolds for tissue engineering. This manuscript describes the application of the gas foaming process for bio-scaffold design and fabrication and highlights some of the most interesting results on: (1) the engineering of porous scaffolds featuring biomimetic porosity to guide cell behavior and to mimic the hierarchical architecture of complex tissues, such as bone; (2) the bioactivation of the scaffolds through the incorporation of inorganic fillers and drugs.

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“…Both methods are influenced by temperature, CO 2 pressure, secondary phases, soaking time, presence of cosolvents, and depressurization rate, among the most relevant [ 99 , 100 ].…”

Section: The Bioactivation Of the Scaffolds Through Incorporation Of ...mentioning

confidence: 99%

Section: The Bioactivation Of the Scaffolds Through Incorporation Of ...mentioning

confidence: 99%

Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming

Fanovich,

Di Maio,

Salerno

2023

JFB

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“…Examples of scCO 2 -assisted impregnation include the impregnation process for the dyeing of synthetic and natural textiles [28,29], preparation of drug-eluting implants [30][31][32][33][34][35][36][37], softwood processing [38][39][40][41][42][43], the preparation of hybrid silk material [44] or for food packaging applications [45,46]. In the conservation field, supercritical CO 2 technology is still niche, with a few examples of application such as the cleaning of textiles [47][48][49][50][51], deacidification of paper [52][53][54][55][56] and the removal of pesticides from objects in ethnographic collections [57][58][59].…”

Section: Introductionmentioning

confidence: 99%

Proof-of-Concept Study on the Feasibility of Supercritical Carbon Dioxide-Assisted Consolidation Treatment for a Pair of Goalkeeper Gloves on Synthetic Latex-Based Foam Mock-Ups

Tomás Ferreira,

Bartoletti,

França de Sá

et al. 2024

Sustainability

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This work investigates the suitability of supercritical fluid technology for designing a safe, efficient and sustainable consolidation treatment for a pair of heavily degraded goalkeeper gloves. Traditional methods have revealed themselves as unsafe and inefficient, leading to material loss and a minimal enhancement of surface cohesion. To overcome these limitations, the use of supercritical carbon dioxide (scCO2) was explored in a treatment, where scCO2 behaves as a green solvent and consolidant carrier. In-depth and homogeneous application of the consolidant, without the need for direct contact with the foam material, was sought. As a proof of concept, the procedure was tested on samples that mimic the synthetic latex-based foam composition and condition of the object. Poly(vinyl acetate) was selected as a consolidant because its behaviour and solubility in scCO2 are known. Several experimental conditions were explored to assess the impact and feasibility of the scCO2-assisted consolidation procedure. Empirical observations, optical microscopy, scanning electron microscopy and infrared spectroscopy were used to monitor potential modifications in the samples and assess the treatment efficacy. The results highlighted the advantages and pitfalls of scCO2-assisted consolidation, paving the way for fine-tuning the process. It neither damaged the fragile surfaces of the foam samples nor increased material loss, which is an advantage compared to traditional treatments. The performed analysis suggested that homogeneous impregnation of the foams was achieved. This study might be a turning point in the conservation of foam-based museum objects, as the results indicate the suitability of the scCO2-assisted consolidation process as a non-toxic and more efficient alternative, being safer for the object.

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“…These fluids are characterized by their safety, being ecologically friendly and economically viable. SC-CO2 is the most widely used solvent in this context, being preferred in several areas, such as food, cosmetics, pharmaceuticals, and biomedicines, due to its versatility for a variety of applications [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Enzymic Deactivation in Tender Coconut Water by Supercritical Carbon Dioxide

Poça D’Água,

Silva,

Oliveira

et al. 2024

Processes

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Polyphenol oxidase (PPO) and peroxidase (POD) are target enzymes in the processing of tender coconut water (TCW). This study primarily evaluated the combined effect of supercritical carbon dioxide (SC-CO2) and mild temperatures on the PPO and POD deactivation of TCW. A factorial design was performed to investigate the effect of temperature (in the range of 35 to 85 °C), pressure (75 to 370 bar), and holding time (13 to 47 min) on the enzymic deactivation, physicochemical parameters, and color of the TCW. The percentages of reduction in PPO activity ranged from 3.7 to 100%, and POD ranged from 43.4 to 100%. The pH values of the freshly extracted and processed TCW were 5.09 and 4.90, and the soluble solids content were 5.5 and 5.4 °Brix, respectively. The holding time (t) had a significant effect (p ≤ 0.1) on the total color variation. As for the reduction of PPO activity, the temperature (T) and the interaction between pressure (P) and t had a significant effect. None of variables (P, T, or t) affected (p > 0.1) the POD reduction, pH, and soluble solids variation. The combination of SC-CO2 and mild temperatures is a promising intervention in the enzymic stabilization of TCW.

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Supercritical CO2-assisted impregnation/deposition of polymeric materials with pharmaceutical, nutraceutical, and biomedical applications: A review (2015–2021)

Cited by 13 publications

References 156 publications

Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming

Current Trend and New Opportunities for Multifunctional Bio-Scaffold Fabrication via High-Pressure Foaming

Proof-of-Concept Study on the Feasibility of Supercritical Carbon Dioxide-Assisted Consolidation Treatment for a Pair of Goalkeeper Gloves on Synthetic Latex-Based Foam Mock-Ups

Enzymic Deactivation in Tender Coconut Water by Supercritical Carbon Dioxide

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