Supercritical-CO2-Assisted Electrospray for the Production of the PLA-Antibiotic-Sustained Drug-Delivery System
Mariangela Guastaferro,
Lucia Baldino,
Stefano Cardea
et al.
Abstract:Supercritical CO2 (SC-CO2)-assisted electrospray has been successfully performed to obtain a sustained release of ceftriaxone sodium (CFX) from polylactic acid (PLA) nanoparticles. PLA nanoparticles ranged from 270 ± 70 to 310 ± 80 nm, when produced at 140 bar. CFX release in a phosphate-buffered solution ranged from about 5 min, when the pure antibiotic was tested, to a maximum of 1200 min when 140 bar and 4 wt% of PLA + CFX nanoparticles was used: operating at these process conditions, an increase of 240 tim… Show more
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