Supercritical carbon dioxide processed resorbable polymer nanocomposite bone graft substitutes

Baker, Kevin C.; Manitiu, Mihai; Bellair, Robert; Gratopp, Carly A.; Herkowitz, Harry N.; Kannan, Rangaramanujam M.

doi:10.1016/j.actbio.2011.05.014

Cited by 16 publications

(10 citation statements)

References 29 publications

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“…Many reports show that different processing techniques based on supercritical carbon dioxide (scCO 2 ) constitute effective ways to increase dispersion and delamination in polymer/clay nanocomposites (Ma et al, 2007; Nguyen and Baird, 2007; Treece and Oberhauser, 2007; Samaniuk et al, 2009; Baker et al, 2011; Feng-hua et al, 2011; Chen et al, 2012). However, X-ray characterization of most samples show the presence of basal 00 l reflections, clearly indicating that treatments with scCO 2 are generally unsui to induce complete organoclay exfoliation (Ma et al, 2007; Nguyen and Baird, 2007; Treece and Oberhauser, 2007; Samaniuk et al, 2009; Thompson et al, 2009; Baker et al, 2011; Feng-hua et al, 2011; Chen et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…However, X-ray characterization of most samples show the presence of basal 00 l reflections, clearly indicating that treatments with scCO 2 are generally unsui to induce complete organoclay exfoliation (Ma et al, 2007; Nguyen and Baird, 2007; Treece and Oberhauser, 2007; Samaniuk et al, 2009; Thompson et al, 2009; Baker et al, 2011; Feng-hua et al, 2011; Chen et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

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Clay exfoliation and polymer/clay aerogels by supercritical carbon dioxide

et al. 2013

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Supercritical carbon dioxide (scCO2) treatments of a montmorillonite (MMT) intercalated with ammonium cations bearing two long hydrocarbon tails (organo-modified MMT, OMMT) led to OMMT exfoliation, with loss of the long-range order in the packing of the hydrocarbon tails and maintenance of the long-range order in the clay layers. The intercalated and the derived exfoliated OMMT have been deeply characterized, mainly by X-ray diffraction analyses. Monolithic composite aerogels, with large amounts of both intercalated and exfoliated OMMT and including the nanoporous-crystalline δ form of syndiotactic polystyrene (s-PS), have been prepared, by scCO2 extractions of s-PS-based gels. Also for high OMMT content, the gel and aerogel preparation procedures occur without re-aggregation of the exfoliated clay, which is instead observed for other kinds of polymer processing. Aerogels with the exfoliated OMMT have more even dispersion of the clay layers, higher elastic modulus and larger surface area than aerogels with the intercalated OMMT. Extremely light materials with relevant transport properties could be prepared. Moreover, s-PS-based aerogels with exfoliated OMMT could be helpful for the handling of exfoliated clay minerals.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clay exfoliation and polymer/clay aerogels by supercritical carbon dioxide

et al. 2013

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“…Their approach achieved scaffolds of 80% porosity with a compressive strength of 2 MPa, a result significantly higher than that typically reported for PLA matrices reinforced with calcium phosphates, silicates or phosphate glasses144 though still short of the 4–12 MPa of trabecular bone 138. The mechanical properties of PLA were further enhanced by Baker et al137 who employed supercritical carbon dioxide (scCO2) processing to simultaneously aid the dispersion of the clay nanoparticles and impart a porous structure to a Cloisite (93A)–PLA nanocomposite. Using this approach, nanocomposites containing 2.5% clay mineral achieved an average compressive strength of 7.15 ± 2.02 MPa and an average compressive modulus of 68.42 ± 32.41 MPa 137.…”

Section: Clay‐polymer Interactionsmentioning

confidence: 91%

“…Clay nanoparticles have been applied to porous polymer scaffolds to enhance compressive strength and stiffness (modulus) 133–141. The combination of high porosity and compressive strength remains an on‐going challenge in scaffold design for tissue engineering, particularly in bone repair, and polymer–clay nanocomposites have demonstrated considerable potential in this regard.…”

Section: Clay‐polymer Interactionsmentioning

confidence: 99%

“…The mechanical properties of PLA were further enhanced by Baker et al137 who employed supercritical carbon dioxide (scCO2) processing to simultaneously aid the dispersion of the clay nanoparticles and impart a porous structure to a Cloisite (93A)–PLA nanocomposite. Using this approach, nanocomposites containing 2.5% clay mineral achieved an average compressive strength of 7.15 ± 2.02 MPa and an average compressive modulus of 68.42 ± 32.41 MPa 137. These approaches thus uniquely allow for the generation of hard porous scaffolds with strength and stiffness approximating that of trabecular bone offer considerable promise for bone tissue engineering applications.…”

Section: Clay‐polymer Interactionsmentioning

confidence: 99%

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Clay: New Opportunities for Tissue Regeneration and Biomaterial Design

2013

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Seminal recent studies that have shed new light on the remarkable properties of clay interactions suggest unexplored opportunities for biomaterial design and regenerative medicine. Here, recent conceptual and technological developments in the science of clay interactions with biomolecules, polymers, and cells are examined, focusing on the implications for tissue engineering and regenerative strategies. Pioneering studies demonstrating the utility of clay for drug‐delivery and scaffold design are reviewed and areas for future research and development highlighted.

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Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders

Erezuma

Eufrásio-da-Silva

Golafshan

et al. 2021

Adv Healthcare Materials

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Nanoclay‐reinforced biomaterials have sparked a new avenue in advanced healthcare materials that can potentially revolutionize treatment of musculoskeletal defects. Native tissues display many important chemical, mechanical, biological, and physical properties that engineered biomaterials need to mimic for optimal tissue integration and regeneration. However, it is time‐consuming and difficult to endow such combinatorial properties on materials via feasible and nontoxic procedures. Fortunately, a number of nanomaterials such as graphene, carbon nanotubes, MXenes, and nanoclays already display a plethora of material properties that can be transferred to biomaterials through a simple incorporation procedure. In this direction, the members of the nanoclay family are easy to functionalize chemically, they can significantly reinforce the mechanical performance of biomaterials, and can provide bioactive properties by ionic dissolution products to upregulate cartilage and bone tissue formation. For this reason, nanoclays can become a key component for future orthopedic biomaterials. In this review, we specifically focus on the rapidly decreasing gap between clinic and laboratory by highlighting their application in a number of promising in vivo studies.

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Supercritical carbon dioxide processed resorbable polymer nanocomposite bone graft substitutes

Cited by 16 publications

References 29 publications

Clay exfoliation and polymer/clay aerogels by supercritical carbon dioxide

Clay exfoliation and polymer/clay aerogels by supercritical carbon dioxide

Clay: New Opportunities for Tissue Regeneration and Biomaterial Design

Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders

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