Supercritical carbon dioxide injection in supersonic beam mass spectrometry

Sin, Chung Hang; Pang, Ho Ming.; Lubman, David M.; Zorn, Jens C.

doi:10.1021/ac00293a051

Cited by 59 publications

(28 citation statements)

References 23 publications

(18 reference statements)

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“…Methods explored so far include laser desorption/ionization or matrix assisted laser desorption/ionization, 1-5 electrospray generation, 6,7 and the expansion of supercritical solutions into a molecular beam. [8][9][10][11][12][13][14] In the latter approach the key idea is to dissolve the substance at high pressure, exploiting the supercritical fluid's solvent power, and precipitate it by expansion. The use of supercritical fluids as solvents offers various advantages: One is that a solvent such as carbon dioxide is compatible with hydrocarbon-free ultrahigh vacuum conditions.…”

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confidence: 99%

Pulsed supersonic expansion of nonvolatile solids

Christen

Geggier

Григоренко

et al. 2004

Review of Scientific Instruments

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confidence: 99%

Pulsed supersonic expansion of nonvolatile solids

Christen

Geggier

Григоренко

et al. 2004

Review of Scientific Instruments

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“…The LD/SJMPI study is carried out with a pulsed C02 laser (Allmark Model 852, A-B lasers Inc., Acton, MA) that generates 10.6-Mm IR radiation with a 75-ns initial pulse and 2-ms tailing. The repetition rate of the laser can be adjusted from 0.1 to 15 Hz, although a 10 Hz repetition rate is used here.…”

Section: Resultsmentioning

confidence: 99%

“…It has been shown that a two-dimensional detection scheme based on a jet-cooled R2PI wavelength spectrum and MPI mass spectrum can provide a powerful means of molecular identification and structural analysis with high sensitivity and selectivity. To extend this SJS/MPI mass spectrometry technique for the study of thermally labile biological molecules, several methods including supercritical fluid injection (10) and thermospray/heating (11) have been attempted to introduce these molecules into the supersonic jet. More recently, laser desorption (LD) has been successfully used to entrain biological molecules into jet expansions (12,13).…”

Section: Introductionmentioning

confidence: 99%

Pulsed fast atom bombardment sample desorption with multiphoton ionization in a supersonic jet/reflectron time-of-flight mass spectrometer

Liang¹,

Hogg²,

Wang³

et al. 1991

Anal. Chem.

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A novel method is presented for performing principal component analysis on a spectral data set. The method Is fast, reliable, and conceptually easy to follow. The orthogonalization Is completed by means of a series of averages. An Initial pass through the data yields the first average or loading vector. In each succeeding pass, a new loading vector and the scores for the previously calculated vector are determined. The method has been applied to the analysis of broad-band UV spectra and to near-infrared gas-phase spectra. The results are both qualitatively and quantitatively comparable to standard methods such as the Jacobi transformation, Householder reduction, singular value decomposition, and nonlinear Iterative partial least squares (NIPALS). In terms of computational efficiency, the successive average approach Is bettered only by Gram-Schmidt orthogonalization, which does not provide the benefits of a principal component analysis.

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“…This carbonization is minimized by lowering the heating temperature and also by rapid increase in the temperature and decrease in the time of heating. A supercritical fluid containing analytes can be expanded into a vacuum to form a supersonic jet [28][29][30]. Especially, carbon dioxide (CO 2 ) has a low critical temperature (31.0 °C), so that it can be used for the measurement of nonvolatile or thermally labile molecules.…”

Section: Analyte Introduction Methodsmentioning

confidence: 99%

Critical assessment: Use of supersonic jet spectrometry for complex mixture analysis (IUPAC Technical Report)

Imasaka¹,

Moore²,

Vo‐Dinh³

2003

Pure and Applied Chemistry

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Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without theAbstract: When cooled to a temperature of a few K using supersonic jet expansion into a vacuum, a molecule exists in the lowest vibrational level of the ground electronic state and is isolated at collision-free conditions. The absorption or excitation/fluorescence spectrum is then greatly simplified, when transitions occur from this single vibrational level to a limited number of vibrational levels in the excited electronic state. This method, called supersonic jet spectrometry, is a powerful analytical technique because of its high selectivity, since the chemical species can be accurately identified and selectively quantified using the sharp spectral features even for large molecules. Supersonic jet spectrometry has distinct advantages over other low-temperature spectrometries, in that it can be combined with gas-phase separation and detection techniques such as chromatography or mass spectrometry. Therefore, this spectrometric technique can be used as a versatile analytical means, not only for basic research on pure substances, but also for practical trace analysis of chemical species in multicomponent samples (e.g., in biological monitoring or in environmental monitoring).

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Supercritical carbon dioxide injection in supersonic beam mass spectrometry

Cited by 59 publications

References 23 publications

Pulsed supersonic expansion of nonvolatile solids

Pulsed supersonic expansion of nonvolatile solids

Pulsed fast atom bombardment sample desorption with multiphoton ionization in a supersonic jet/reflectron time-of-flight mass spectrometer

Critical assessment: Use of supersonic jet spectrometry for complex mixture analysis (IUPAC Technical Report)

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