Supercritical Carbon Dioxide and Subcritical Water: Complementary Agents in the Processing of Functional Foods

Srinivas, Keerthi; King, Jerry W.

doi:10.1002/9781444323351.ch3

Cited by 11 publications

(6 citation statements)

References 117 publications

(101 reference statements)

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“…This process is extremely accurate since it is based on binding molecules in accordance with a specific fixing pattern, allowing a specific extraction at almost 100%. While other extraction techniques, like supercritical coupled with adsorbents (silica gel), allow the extraction of β‐carotene isomers, as described by Mendes and his collaborators in 2003 (Mendes et al., 2003 ; Srinivas & King, 2010 ), this process could be qualified as the most specific extraction technique as it extracts pure β‐carotene molecules which could be intended for pharmaceutical or cosmetic use. Nevertheless, this pioneer method could overcome the highly expensive price of the chemical synthesis of the cis β‐carotene form.…”

Section: Discussionmentioning

confidence: 99%

Design and use of chimeric peptides in a new non‐destructive ecological process applied to the extraction of all trans/9‐cis β‐carotene isomers from Dunaliella salina

Kouidhi

Mnif

Alqarni

et al. 2022

Food Science & Nutrition

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Recently, β‐carotene has gained tremendous importance as a bioactive molecule due to the growing awareness of the harmful effects of synthetic products. β‐carotene is a high‐value natural pigment that has the highest demand in the global carotenoid market owing to its proven antioxidant properties relevant for several diseases. To date, Dunaliella salina is the most important producer of natural β‐carotene and is the subject of important industrial efforts. However, the extraction of β‐carotene remains challenging since all the proposed techniques present a risk of product contamination or loss of quality due to solvent residuals and low yields. The purpose of this study was to set up a green, ecological, and innovative process of extraction of the two major β‐carotene isomers from the halophilic microalgae Dunaliella salina. Based on molecular modeling, docking, and drug design, we conceived and synthesized two chimeric peptides (PP2, PP3) targeting specifically the two major isomers: all‐trans or 9‐cis β‐carotene. The experimental protocol used in this study demonstrated the ability and the efficacy of those two peptides to cross the cell membrane and bind with high affinity to β‐carotene isomers and exclude them toward the extracellular medium while preserving the integrity of living cells. Interestingly, the tested peptides (PP2, PP3) exhibit significant β‐carotene extraction yields 58% and 34%, respectively, from the total of the β‐carotene in microalgae cells. In addition to its simplicity, this process is fast, independent of the source of the β‐carotene, and selective. These results would allow us to set up a green, ecological, and very profitable process of extraction from microalgae containing high amounts of β‐carotene. Our innovative approach is highly promising for the extraction of Dunaliella salina biomass on an industrial scale.

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Section: Discussionmentioning

confidence: 99%

Design and use of chimeric peptides in a new non‐destructive ecological process applied to the extraction of all trans/9‐cis β‐carotene isomers from Dunaliella salina

Kouidhi

Mnif

Alqarni

et al. 2022

Food Science & Nutrition

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“…Possibly the use of lower concentration of H 2 O, which is in the liquid state, increased the moisture of the baru almond and thus allowed for greater extraction of tocopherols by the system formed by the two phases (CO 2 and H 2 O) , moreover making the extraction solvent more polar and increasing the extraction of tocopherols that are moderately polar. In addition to parameters such solubility of bioactive compounds Value-adding Baru Oil by SC-CO 2 Extraction Using H 2 O as Cosolvent in the system formed by CO 2 and cosolvents, temperature and pressure, and particle size, moisture can also interfere in the extraction of bioactive compounds, such as tocopherols 39) . A similar behaviour was also observed by Silva et al 20) , who found that pomegranate seed oil extracted by SC-CO 2 was enriched in tocopherols when the cosolvent was composed of 90％ water and 10％ alcohol, compared to using pure alcohol.…”

Section: Baru Oil Extraction By Sc-co 2 : Tuning Extraction Yieldmentioning

confidence: 99%

Baru (<i>Dipteryx alata</i> Vogel) Oil Extraction by Supercritical-CO<sub>2</sub>: Improved Composition by Using Water as Cosolvent

et al. 2022

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“…The first application of SFE to foodstuff dates back from the early 1970s, when this technique was used in the decaffeination of coffee beans. Afterwards, when SFE was recognized as a "green" procedure, its application was boosted and several nutraceutical ingredients, e.g., carotenoid pigments, sterols, tocopherols, or polyphenolic compounds were extracted using this methodology (Srinivas & King, 2010). iv) Accelerated solvent extraction (ASE), is made with the same solvents, but using higher pressure and elevated temperatures, presenting the additional advantages of enabling the extraction of fresh samples, shorter extraction times, higher automation and good extraction kinetics.…”

Section: Extraction Of Bioactive Compoundsmentioning

confidence: 99%

Natural phytochemicals and probiotics as bioactive ingredients for functional foods: Extraction, biochemistry and protected-delivery technologies

Silva

Barreira

Oliveira

2016

Trends in Food Science & Technology

185

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Background: The well-known correlation between diet and physiology demonstrates the great possibilities of food to maintain or improve our health, increasing the interest in finding new products with positive physiological effects. Nowadays, one of the top research areas in Food Science and Technology is the extraction and characterization of new natural ingredients with biological activity that can be further incorporated into a functional food, contributing to consumer's well-being. Furthermore, there is a high demand for effective encapsulation methodologies to preserve all the characteristics of bioactive compounds until the physiological action site is reached. Scope and approach: In this review, the relevance of developing standard approaches for the extraction of the highly diverse bioactive compounds was described, as it defines the suitability of the following steps of separation, identification and characterization. Special attention was also dedicated to the encapsulation techniques used on hydrophilic and/or lipophilic compounds (e.g., emulsification, coacervation, supercritical fluid, inclusion complexation, emulsification-solvent evaporation and nanoprecipitation). Key findings and conclusions: Some useful conclusions regarding the selection of the best extraction methodology (Soxhlet extraction, ultrasound-assisted extraction, supercritical fluid extraction, accelerated solvent extraction, or shake extraction) were achieved, considering important aspects such as cost, required technical skills, extract integrity, green chemistry principles, solvent type, sample size, pH, temperature and pressure. In addition, this comprehensive review allowed defining the best protective approach to solve the limitations related to the extremely low absorption and bioavailability of bioactive phytochemicals, overcoming problems related to their low solubility, poor stability, low permeability and metabolic processes in the GI tract.

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Supercritical Carbon Dioxide and Subcritical Water: Complementary Agents in the Processing of Functional Foods

Cited by 11 publications

References 117 publications

Design and use of chimeric peptides in a new non‐destructive ecological process applied to the extraction of all trans/9‐cis β‐carotene isomers from Dunaliella salina

Design and use of chimeric peptides in a new non‐destructive ecological process applied to the extraction of all trans/9‐cis β‐carotene isomers from Dunaliella salina

Baru (<i>Dipteryx alata</i> Vogel) Oil Extraction by Supercritical-CO<sub>2</sub>: Improved Composition by Using Water as Cosolvent

Natural phytochemicals and probiotics as bioactive ingredients for functional foods: Extraction, biochemistry and protected-delivery technologies

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