Supercritical assisted process for the efficient production of liposomes containing antibiotics for ocular delivery

Campardelli, Roberta; Reverchon, Ernesto

doi:10.1016/j.jcou.2018.04.006

Cited by 37 publications

(18 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the various nanometric systems, liposomes already stand out as promising for ocular drug delivery, due to their biocompatibility and ability to increase drug penetration into ocular tissues [ 83 , 84 , 85 ]. Liposomes are spherical amphipathic vesicles, characterized by a double layer of phospholipids with an internal aqueous cavity.…”

Section: Methods Of Loading Active Principles Into Contact Lensesmentioning

confidence: 99%

“…An innovative and completely different process for loading liposomes with antibiotics was used by Campardelli at al. [ 85 ], which produced liposomes containing ampicillin and ofloxacin using a supercritical CO 2 based one-step continuous process, named Supercritical Assisted Liposome formation (SuperLip).…”

Section: Methods Of Loading Active Principles Into Contact Lensesmentioning

confidence: 99%

See 1 more Smart Citation

Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Franco

Marco

2021

Polymers

View full text Add to dashboard Cite

Ophthalmic drugs used for the treatment of various ocular diseases are commonly administered by eye drops. However, due to anatomical and physiological factors, there is a low bioavailability of the active principle. In order to increase the drug residence time on the cornea to adequate levels, therapeutic contact lenses have recently been proposed. The polymeric support that constitutes the contact lens is loaded with the drug; in this way, there is a direct and effective pharmacological action on the target organ, promoting a prolonged release of the active principle. The incorporation of ophthalmic drugs into contact lenses can be performed by different techniques; nowadays, the soaking method is mainly employed. To improve the therapeutic performance of drug-loaded contact lenses, innovative methods have recently been proposed, including the impregnation with supercritical carbon dioxide. This updated review of therapeutic contact lenses production and application provides useful information on the most effective preparation methodologies, recent achievements and future perspectives.

show abstract

Section: Methods Of Loading Active Principles Into Contact Lensesmentioning

confidence: 99%

Section: Methods Of Loading Active Principles Into Contact Lensesmentioning

confidence: 99%

Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Franco

Marco

2021

Polymers

View full text Add to dashboard Cite

show abstract

“…Recent studies [115][116][117][118] demonstrated the feasibility of scCO 2 application in liposome production. Conventional methods of liposome production suffer from drawbacks, such as the difficulty of controlling particle size distribution, micrometric dimensions, low stability, and high solvent residue [117].…”

Section: Other Methodsologies Applied To the Development Of Antibactermentioning

confidence: 99%

“…To overcome these deficiencies, Santo et al [115] and Trucillo et al [116] developed a continuous supercritical assisted process called SuperLip (Supercritical assisted Liposome formation), characterized with good control of particle size distribution, possibility to produce liposomes on a nanometric or micrometric level, liposome stability of over one year, and solvent residue in liposomes lower than FDA limits [116]. The SuperLip process was successfully applied to the production of liposomes with antimicrobial activity loaded with vancomycin [116], amoxicillin [117], ampicillin, and ofloxacin [118]. In this process, an ethanol solution of phospholipids is brought to contact with scCO 2 at 10 MPa and 40 • C in a saturator vessel first.…”

Section: Other Methodsologies Applied To the Development Of Antibactermentioning

confidence: 99%

Supercritical Fluid Applications in the Design of Novel Antimicrobial Materials

Žižović

2020

Molecules

View full text Add to dashboard Cite

Bacterial resistance to antibiotics is one of the biggest problems in the modern world. The prevention of bacterial spreading from hospitals to the community and vice versa is an issue we have to deal with. This review presents a vast potential of contemporary high-pressure techniques in the design of materials with antimicrobial activity. Scientists from all over the world came up with ideas on how to exploit extraordinary properties of supercritical fluids in the production of advantageous materials in an environmentally friendly way. The review summarizes reported methods and results.

show abstract

“…Drug-IER complexes are insoluble in water and tend to release the drug from exchange of bound drug ions by ions normally present in body fluids [27,28] . Traditionally IER is utilized for taste masking and sustained drug release in oral formulations [29,30,31,32,33] .IER is enormously used in variety of drug delivery systems [34 such as adhesive in conjugation with nanoparticles for subcutaneous delivery [35] , dental adhesive [36] and ocular sustained drug release [37] . Drug-IER complex suspension is approved and commercially available in US market for ophthalmic delivery as Betoptic S ® [38] .…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Moxifloxacin Nanoparticles with Ion Exchange Resin

Vyas¹,

Daxini²,

Patel³

2020

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Moxifloxacin (MOX) is a fluoroquinolone anti-infective drug, indicated for the treatment of bacterial conjunctivitis. The drug is soluble in water but still produces low ocular bioavailability due to biological barriers and so it requires dosing for two/three times a day. The present study was designed to formulate, optimize and characterize polymeric Nanoparticles MOX for ocular administration using Ion Exchange Resin (IER). IER-nanoparticles were prepared by media milling method, formulation/process parameters were optimized based on evaluation parameters such as color of nanosuspension, sedimentation behaviour, particle size and zeta potential. MOX-IER nanosuspensions were prepared at different stoichiometric ratio of MOX and IER and characterized by entrapment efficiency, pH, particle size and zeta potential of nanosuspension. In vitro release study of optimized batch MNIER3 exhibited sustained release pattern which follows Korsmeyer-Peppas model with Fickian diffusion mechanism for drug release. Based on these results optimized batch of MOX-IER nanosuspension formulated in the laboratory was found suitable for ocular delivery. Keywords: Moxifloxacin; nanoparticles, nanosuspension; media milling; stoichiometric ratio; sedimentation behaviour.

show abstract

Supercritical assisted process for the efficient production of liposomes containing antibiotics for ocular delivery

Cited by 37 publications

References 39 publications

Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Supercritical Fluid Applications in the Design of Novel Antimicrobial Materials

Formulation and Characterization of Moxifloxacin Nanoparticles with Ion Exchange Resin

Contact Info

Product

Resources

About