Supercritical antisolvent fractionation of propolis tincture

Catchpole, Owen J.; Grey, John B.; Mitchell, Kevin; Lan, Jianwu

doi:10.1016/s0896-8446(03)00033-0

Cited by 84 publications

(44 citation statements)

References 8 publications

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“…According to Catchpole et al (2004), propolis is not very soluble in supercritical CO 2 , but much more soluble in the mixture of CO 2 + ethanol. As can be seen in Table 3, the results show that the supercritical extractions using ethanol as co-solvent produced extracts with much higher global yields than those extracted without the co-solvent.…”

Section: Supercritical Fluid Extraction Of Raw Propolismentioning

confidence: 99%

“…Supercritical carbon dioxide (sc-CO2) has also been applied to propolis, yielding highly valuable products (Catchpole et al, 2004;Wang and Yu et al, 2004). Raw propolis was extracted by Stahl et al (1988) using supercritical CO 2 at 600 bar and 40°C to extract the wax and leave the insoluble flavonoids behind.…”

Section: Introductionmentioning

confidence: 99%

“…Raw propolis was extracted by Stahl et al (1988) using supercritical CO 2 at 600 bar and 40°C to extract the wax and leave the insoluble flavonoids behind. Catchpole et al (2004) used sc-CO 2 both as an antisolvent to precipitate high molecular mass components, and also as a solvent to extract the ethanol and the soluble components of the EEP (nondried). Lee et al (2007) extracted DHCA from Brazilian propolis using sc-CO 2 modified with cosolvent, followed by column chromatography, to obtain very pure DHCA.…”

Section: Introductionmentioning

confidence: 99%

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Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Paviani

Saito

Dariva

et al. 2012

Braz. J. Chem. Eng.

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-Three types of propolis extract were prepared and analyzed with respect to their global extraction yields and with respect to the concentration of the following markers: 3,5-diprenyl-4-hydroxycinnamic acid; 3-prenyl-4-hydroxycinnamic acid; 4-hydroxycinnamic acid and 4-methoxy-3,5,7-trihydroxyflavone. The extract EEP (ethanolic extract of propolis) was obtained by the conventional method from raw propolis using ethanol as solvent. The extracts (SFE) were obtained by supercritical solvent extraction from the raw propolis using supercritical carbon dioxide (sc-CO 2 ), with and without the addition of ethanol as a co-solvent. The fractionated supercritical extracts (FSCE) were obtained by fractionation (extract and raffinate) of the dry EEP with sc-CO 2 . EEP yields of 39.5% were obtained and maximum global extraction yields were 7.3% for SFE with no co-solvent, 51% for SFE with 15% ethanol and 18% for the FSCE extract fraction. The concentrations of the markers in the different extracts differed as a function of the operational parameters, indicating that the addition of co-solvent and the selectivity of sc-CO 2 could be manipulated so as to obtain extracts with the yields and concentrations of interest.

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Section: Supercritical Fluid Extraction Of Raw Propolismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Paviani

Saito

Dariva

et al. 2012

Braz. J. Chem. Eng.

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“…However, SC-CO 2 extraction has its limitation. For example, polar compounds such as flavonoids cannot be extracted by SC-CO 2 alone (Anna et al, 2004;Catchpole et al, 2004;de Maria et al, 1997). The flavonoids remain in the waste product of the hops processing industry.…”

Section: Introductionmentioning

confidence: 99%

Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulusL.)

Hao-ping

Chen

et al. 2005

J. Zhejiang Univ. Sci.

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Waste hops are good sources of flavonoids. Extraction of flavonoids from waste hops (SC-CO 2 extracted hops) using supercritical fluids technology was investigated. Various temperatures, pressures and concentrations of ethanol (modifier) and the ratio (w/w) of solvent to material were tested in this study. The results of single factor and orthogonal experiments showed that at 50 °C, 25 MPa, the ratio of solvent to material (50%), ethanol concentration (80%) resulted in maximum extraction yield flavonoids (7.8 mg/g). HPLC-MS analysis of the extracts indicated that flavonoids obtained were xanthohumol, the principal prenylflavonoid in hops.

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“…This difference between the samples can be attributed to the solubilization of some co mpounds in supercritical CO 2 during anti solvent process [24]. Further improvements in our equipment in order to determine this loss will be done.…”

Section: Comparison Betweenthe Ple Extracts Sas Precipitated Extractmentioning

confidence: 99%

Pressurized Organic Solvent Extraction with On-line Particle Formation by Supercritical Anti Solvent Processes

Santos¹,

Barbosa²,

Broccolo³

et al. 2012

fph

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In this work, anovel on-line process for pressurised hot organic solvent extraction of antio xidants from plantsas well as precip itation of the extract with or without a carrier material in one step was developed. This process has been called OEPO,Organic solvent Ext raction and On-line particle formation. With this process, different products with a very low residual organic solvent concentration (< 50 ppm) can be obtained by the use of supercritical CO 2 as anti solvent for solvent elimination.OEPO process consists of hyphenated Pressurized Liquid Extraction (PLE)-Supercritical Anti So lvent (SAS) precipitation, PLE-SAS co-p recipitat ion and PLE-Supercritical Fluid Ext raction of Emulsions (SFEE). OEPO process was successfully developed using Brazilian g inseng roots (Pfa ffiaglomerata)as a model case using ethyl acetate as extracting solvent. Results were co mpared, in terms of antio xidant activity o r mo rphology, with the ones obtained by each process separately.In addition, an optimizat ion study for antio xidants recovery was performed using ethyl acetate as extracting solvent during PLE process. Optimu m PLE extracts were produced under moderate extraction temperature (373 K) and high static extraction t ime (15 min). Under this condition an ext raction yield o f 1% (d ry basis, d.b.) and an antioxidant activity of 53% are obtained, wh ich was appro ximately 14% higherthan that observed after PLE-SAS p recipitation and after SAS precipitation performed in two steps (step one -PLE ext raction; step two -SAS precipitation by the use of the ext ract solution produced by step one stored).Similar behavior (hyphenated process producing similar p roducts than the two step process done separately) was observed for PLE-SAS co-precip itation and PLE-SFEE indicating that the OEPO process developed in this work can be considered as a suitable and p ro mising process to obtain, in only one step, different products (precipitated extract, co-precipitated extract or encapsulated extract in suspension), direct ly fro m plant materials.

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Supercritical antisolvent fractionation of propolis tincture

Cited by 84 publications

References 8 publications

Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulusL.)

Pressurized Organic Solvent Extraction with On-line Particle Formation by Supercritical Anti Solvent Processes

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