Supercharging green chemistry: Unleashing 1, 4‐NADH regeneration and unprecedented C(sp³)‐F bond activation via NiS‐NiO/S‐g‐C₃N₄ nanocomposite photocatalyst under solar light

Abstract

Fluorinated and enzymatic chemicals are widely used in society due to their chemical, physical, and biological qualities. Nevertheless, despite their vital importance, present approaches to adding fluorine to molecules and regenerating enzyme cofactors have serious flaws. For instance, numerous approaches are photocatalytic and employ stoichiometric counterparts of heavy metals. Prevailing photocatalytic approaches, on the other hand, show very poor activity, and selectivity has not been attained by heterogeneous photocatalysis, despite the several benefits such a method would provide. Here, we show how heterogeneous photocatalysis may be used to selectively create C(sp3)‐F bonds and 1,4‐NADH regeneration cofactor. Employing NiS‐NiO/S‐g‐C3N4 nanocomposite photocatalyst as a photocatalyst, NAD+ and Selectfluor as an acceptor and mild fluorine donor, effective 1,4‐NADH regeneration, and decarboxylative fluorination of carboxylic acids can be attained in very short reaction times. Furthermore, NiS‐NiO/S‐g‐C3N4 nanocomposite photocatalyst exhibits outstanding levels of robustness and photo‐catching capacity. These aspects, attached to the mild environment of the reaction scheme, exhibit a breakthrough toward the sustainable cofactor of 1,4‐NADH regeneration and synthesis of fluorinated compounds.