“…There have been a number of cases of PRP associated with infection 13,14 including HIV. 15,16 Therefore, a topical compound, such as imiquimod, that promotes an antiviral cytokine profile could conceivably result in the exacerbation of PRP. Furthermore, although the cytokine profile for PRP is still unknown, imiquimod increases the levels of TNF-α , whose inhibition has led to successful treatment of PRP.…”