Super-short solid silicon microneedles for transdermal drug delivery applications

Li, Weize; Huo, Meirong; Zhou, Jianping; Yong-Qiang, Zhou; Bao-hua, Hao; Liu, Ting; Zhang, Yong

doi:10.1016/j.ijpharm.2010.01.024

Cited by 140 publications

(71 citation statements)

References 27 publications

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“…They can be categorized into two types, solid or hollow MNs (Bariya et al, 2011). The materials that have been used to fabricate them range from metal (Choi et al, 2013), glass, silicon (Wei-Ze et al, 2010) and biodegradable polymers (polydimethylsiloxane) (Chu & Prausnitz, 2011;Bediz et al, 2013) and silk fibroin (Tsioris et al, 2012). More recently, the use of fish scales have also been investigated (Olatunji et al, 2014).…”

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

“…(Henry et al, 1998;Park et al, 2005;Gupta et al, 2009;Swain et al, 2011;Kommareddy et al, 2013;Mansoor et al, 2013;Torrisi et al, 2013;Pierre & Rossetti, 2014). There has been a lot of research conducted on MNs for the delivery and monitoring of various drugs such as glucose control for diabetics (Ito et al, 2006;Nordquist et al, 2007;Ainslie & Desai, 2008;El-Laboudi et al, 2013;Taylor & Sahota, 2013;Ita, 2014), Alzheimer's disease (Wei-Ze et al, 2010), anticancer (Fang et al, 2008) and other conditions (Ezan, 2013). Vaccines have also been a prominent research field with numerous studies developed to allow dose sparing effects (Edens et al, 2013;Norman et al, 2014;van der Maaden et al, 2014).…”

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

“…These can be known as ''poke and patch'', ''coat and poke'', formulating the API (active pharmaceutical ingredient) with a biodegradable polymeric MN (Cheung et al, 2014;Nayak et al, 2014) or by channeling the drug through the channels of a hollow MN (Prausnitz, 2004). Multiple MN designs have been fabricated that facilitate the piercing of the SC allowing the permeation of drugs (Wei-Ze et al, 2010).…”

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

“…This shows a promising fabrication method for the delivery of drugs transdermally. Table 3 lists the main parameters of super short MNs in the study conducted by (Wei-Ze et al, 2010). However, considering the various fabrication methods, there seems to be a need for a simpler robust technique that requires minimal cost, as the process is economically viable and relatively robust.…”

Section: Solid Mnsmentioning

confidence: 99%

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Microneedles for drug delivery: trends and progress

2014

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In recent years, there has been a surge in the research and development of microneedles (MNs), a transdermal delivery system that combines the technology of transdermal patches and hypodermic needles. The needles are in the hundreds of micron length range and therefore allow relatively little or no pain. For example, biodegradable MNs have been researched in the literature and have several advantages compared with solid or hollow MNs, as they produce non-sharp waste and can be designed to allow rapid or slow release of drugs. However, they also pose a disadvantage as successful insertion into the stratum corneum layer of the skin relies on sufficient mechanical strength of the biodegradable material. This review looks at the various technologies developed in MN research and shows the rapidly growing numbers of research papers and patent publications since the first invention of MNs (using time series statistical analysis). This provides the research and industry communities a valuable synopsis of the trends and progress being made in this field.

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Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

Section: Solid Mnsmentioning

confidence: 99%

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Microneedles for drug delivery: trends and progress

2014

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“…There are several kinds of MNs, namely, solid MNs for skin pretreatment to increase skin permeability, MNs coated with drugs, hollow MNs for drug infusion into the skin, polymeric or polysaccharide MNs that encapsulate drugs and partially or fully dissolve in the skin [14][15][16][17].…”

Section: Problems Of Non-hydrogel Mnsmentioning

confidence: 99%

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Hong

Chen

et al. 2014

Nano-Micro Lett

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Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding mechanisms. In recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology.

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