Super-resolution imaging for in situ monitoring sub-cellular micro-dynamics of small molecule drug

Dimethyl Dihydrophenazine: A Highly Conjugated Auxochrome in Fluorophores to Improve Photostability, Red-Shift Wavelength, and Enlarge Stokes Shift

“…1−5 This capability is vital for investigating pathological processes and amassing data for drug discovery purposes. 6,7 However, the prolonged and high-power laser irradiation utilized in these techniques necessitates organic fluorophores with sufficient stability to withstand photobleaching.…”

“…The advancement of super-resolution fluorescence microscopy and nanoscopy, such as stimulated emission depletion (STED), facilitates the prolonged visualization of cellular and subcellular morphological intricacies, enabling the exploration of crucial biological dynamics within organelles and tissues. − This capability is vital for investigating pathological processes and amassing data for drug discovery purposes. , However, the prolonged and high-power laser irradiation utilized in these techniques necessitates organic fluorophores with sufficient stability to withstand photobleaching.…”