Super-oxidized solution inhibits IgE-antigen-induced degranulation and cytokine release in mast cells

Medina-Tamayo, Jaciel; Sánchez-Miranda, Elizabeth; Balleza-Tapia, Hugo; Ambriz, Xóchitl; Cid, María Eugenia; González-Espinosa, Diana; Gutierrez, Andres; González-Espinosa, Claudia

doi:10.1016/j.intimp.2007.03.005

Cited by 24 publications

(26 citation statements)

References 33 publications

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“…The survival rate of rats with experimental peritonitis was significantly increased compared to a treatment with NaCl without undesirable effects [138]. By stabilization of the cell membrane, the release of cytokines from mast cells is inhibited without intracellular impairment, possibly contributing to an anti-inflammatory effect [29]. NaOCl/HOCl was not or barely irritating on chick chorioallantoic membranes [323].…”

Section: Sodium Hypochlorite/hypochlorous Acidmentioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

243

215

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Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment.

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Section: Sodium Hypochlorite/hypochlorous Acidmentioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

243

215

View full text Add to dashboard Cite

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“…Beside its microbiocidal efficiency OCl -acts anti-inflammatorily, which is most often based on the inhibition of the release of cytokines [34]. Dermacyn Ò also stabilizes mast cells [34], a major cell group responsible for immunologic reaction of the nose.…”

Section: Discussionmentioning

confidence: 99%

“…Dermacyn Ò also stabilizes mast cells [34], a major cell group responsible for immunologic reaction of the nose. Studies have shown that Dermacyn Ò is well tolerated on skin, mucosa, and even on wounds [12].…”

Section: Discussionmentioning

confidence: 99%

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Eradication of MRSA skull base osteitis by combined treatment with antibiotics and sinonasal irrigation with sodium hypochlorite

Kuster

Krämer

Bremert

et al. 2015

Eur Arch Otorhinolaryngol

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“…In mast cells, these events are mediated through activation of RhoGTPases and mitogen-activated protein kinase pathways (39,40). As well as the activation of signaling cascades to promote degranulation, the receptor also has sequences which interact with the actin cytoskeleton and microtubules, initiating signaling cascades that are calcium dependent and calcium independent, respectively (41,42).…”

Section: Interactions Between Allergens Ige and Fcεri Trigger Hypermentioning

confidence: 99%

Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment

Karagiannis

Josephs

et al. 2013

Microbiol Spectr

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The pathogenic role of immunoglobulin E (IgE) antibodies in triggering and maintaining allergic inflammation in response to allergens is due to the binding of multivalent allergens to allergen-specific IgEs on sensitized effector cells. These interactions trigger effector cell activation, resulting in release of potent inflammatory mediators, recruitment of inflammatory cells, antigen presentation, and production of allergen-specific antibody responses. Since its discovery in the 1960s, the central role of IgE in allergic disease has been intensively studied, placing IgE and its functions at the heart of therapeutic efforts for the treatment of allergies. Here, we provide an overview of the nature, roles, and significance of IgE antibodies in allergic diseases, infections, and inflammation and the utility of antibodies as therapies. We place special emphasis on allergen-IgEFcε receptor complexes in the context of allergic and inflammatory diseases and describe strategies, including monoclonal antibodies, aimed at interrupting these complexes. Of clinical significance, one antibody, omalizumab, is presently in clinical use and works by preventing formation of IgE-Fcε receptor interactions. Active immunotherapy approaches with allergens and allergen derivatives have also demonstrated clinical benefits for patients with allergic diseases. These treatments are strongly associated with serum increases of IgE-neutralizing antibodies and feature a notable redirection of humoral responses towards production of antibodies of the IgG4 subclass in patients receiving immunotherapies. Lastly, we provide a new perspective on the rise of recombinant antibodies of the IgE class recognizing tumor-associated antigens, and we discuss the potential utility of tumor antigen-specific IgE antibodies to direct potent IgE-driven immune responses against tumors.

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Super-oxidized solution inhibits IgE-antigen-induced degranulation and cytokine release in mast cells

Cited by 24 publications

References 33 publications

Consensus on Wound Antisepsis: Update 2018

Consensus on Wound Antisepsis: Update 2018

Eradication of MRSA skull base osteitis by combined treatment with antibiotics and sinonasal irrigation with sodium hypochlorite

Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment

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