Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer

Wang, Xin; Wu, Shuilian; Shen, Liping; Ke, Meixia; Ouyang, Yan; Lin, Mengqi; Lyu, Yiting; Sun, Binuo; Zheng, Zhenzhen; Yang, Jialei; Yang, Jie; Lu, Wen‐Min; Yang, Yiping; Li, Danni; Zou, Yue; Huang, Haishan; Nan, Aruo

doi:10.1016/j.isci.2020.101857

Cited by 14 publications

(13 citation statements)

References 46 publications

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“…In addition to these scenarios, we recently showed that gain‐of‐function mutation in the seed sequences of miRNA‐140, driven by chondrocyte‐specific super‐enhancers, causes autosomal dominant human skeletal dysplasia (“spondyloepiphyseal dysplasia MIR140 type Nishimura”), extending the roles of super‐enhancers in human diseases 7,8 . Although the association between super‐enhancers and long non‐coding RNAs (lncRNAs) in cell identity control has not been explored in depth, certain super–enhancer‐driven lncRNAs (SE‐lncRNAs) have been implicated in cancer pathogenesis 9‐16 . Multifaceted functional crosstalk between super‐enhancers and lncRNAs, including cis and trans gene or super‐enhancer regulation by lncRNAs, has been also suggested 9,13,17,18 …”

Section: Super‐enhancers and Cancer Biologymentioning

confidence: 99%

Biomolecular condensates in cancer biology

Suzuki

Onimaru

2021

Cancer Science

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Understanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective, the super‐enhancer concept has been introduced to systematically understand the molecular mechanisms underlying the identities of various cell types and has been extended to the analysis of cancer cells and cancer genome alterations. In addition, several characteristic features of super‐enhancers have led to the recognition of the link between gene regulation and biomolecular condensates, which is often mediated by liquid‐liquid phase separation. Several lines of evidence have suggested molecular and biophysical principles and their alterations in cancer cells, which are particularly associated with gene regulation and cell signaling (“ transcriptional” and “signaling” condensates). These findings collectively suggest that the modification of biomolecular condensates represents an important mechanism by which cancer cells acquire various cancer hallmark traits and establish functional innovation for cancer initiation and progression. The condensate model also provides the molecular basis of the vulnerability of cancer cells to transcriptional perturbation and further suggests the possibility of therapeutic targeting of condensates. This review summarizes recent findings regarding the relationships between super‐enhancers and biomolecular condensate models, multiple scenarios of condensate alterations in cancers, and the potential of the condensate model for therapeutic development.

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Section: Super‐enhancers and Cancer Biologymentioning

confidence: 99%

Biomolecular condensates in cancer biology

Suzuki

Onimaru

2021

Cancer Science

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“…lncRNA HCCL5 is an SE-driven gene that confers the malignant phenotypes of liver cancer cells [ 105 ]. LINC00162, an SE lncRNA, was highly expressed in bladder cancer cells and tissues, which can promote progression of bladder cancer [ 106 ]. Our team constructed prognostic models for five -genes associated with SEs for osteosarcoma patients and multiple myeloma patients, which accurately predict the prognosis of these cancer patients [ 107 , 108 ].…”

Section: Structures and Functions Of Sesmentioning

confidence: 99%

Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance

et al. 2021

J Exp Clin Cancer Res

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Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy treatments for cancer have improved patient survival, the emergence of chemoresistance in cancer has significant impacts on treatment effects. The development of chemoresistance involves several polygenic, progressive mechanisms at the molecular and cellular levels, as well as both genetic and epigenetic heterogeneities. Chemotherapeutics induce epigenetic reprogramming in cancer cells, converting a transient transcriptional state into a stably resistant one. Super-enhancers (SEs) are central to the maintenance of identity of cancer cells and promote SE-driven-oncogenic transcriptions to which cancer cells become highly addicted. This dependence on SE-driven transcription to maintain chemoresistance offers an Achilles’ heel for chemoresistance. Indeed, the inhibition of SE components dampens oncogenic transcription and inhibits tumor growth to ultimately achieve combined sensitization and reverse the effects of drug resistance. No reviews have been published on SE-related mechanisms in the cancer chemoresistance. In this review, we investigated the structure, function, and regulation of chemoresistance-related SEs and their contributions to the chemotherapy via regulation of the formation of cancer stem cells, cellular plasticity, the microenvironment, genes associated with chemoresistance, noncoding RNAs, and tumor immunity. The discovery of these mechanisms may aid in the development of new drugs to improve the sensitivity and specificity of cancer cells to chemotherapy drugs.

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“…SNHG14 increases the growth and metastasis of BCa and inhibits apoptosis by regulating the miR-211-3p/ESM1 axis [ 88 ]. LINC00162 can regulate PTTG1IP expression by binding THRAP3 to promote cell proliferation and inhibit apoptosis [ 89 ]. Other lncRNAs, such as SNHG7 [ 90 , 91 ], ANRIL [ 92 ], ZEB2-AS1 [ 93 ], OIP5-AS1 [ 94 ], and PART1 [ 95 ], also have the same effects.…”

Section: Cell Apoptosismentioning

confidence: 99%

Biological functions and clinical significance of long noncoding RNAs in bladder cancer

et al. 2021

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Bladder cancer (BCa) is one of the 10 most common cancers with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNAs), a large class of noncoding RNA transcripts, consist of more than 200 nucleotides and play a significant role in the regulation of molecular interactions and cellular pathways during the occurrence and development of various cancers. In recent years, with the rapid advancement of high-throughput gene sequencing technology, several differentially expressed lncRNAs have been discovered in BCa, and their functions have been proven to have an impact on BCa development, such as cell growth and proliferation, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, and drug-resistance. Furthermore, evidence suggests that lncRNAs are significantly associated with BCa patients’ clinicopathological characteristics, especially tumor grade, TNM stage, and clinical progression stage. In addition, lncRNAs have the potential to more accurately predict BCa patient prognosis, suggesting their potential as diagnostic and prognostic biomarkers for BCa patients in the future. In this review, we briefly summarize and discuss recent research progress on BCa-associated lncRNAs, while focusing on their biological functions and mechanisms, clinical significance, and targeted therapy in BCa oncogenesis and malignant progression.

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Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer

Cited by 14 publications

References 46 publications

Biomolecular condensates in cancer biology

Biomolecular condensates in cancer biology

Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance

Biological functions and clinical significance of long noncoding RNAs in bladder cancer

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