SuPAR is associated with death and adverse cardiovascular outcomes in patients with suspected coronary artery disease

Hodges, Gethin W.; Lyngbæk, Stig; Selmer, Christian; Ahlehoff, Ole; Theilade, Simone; Sehestedt, Thomas; Abildgaard, Ulrik; Eugen‐Olsen, Jesper; Galløe, Anders; Hansen, Peter Riis; Jeppesen, Jørgen; Bang, Casper N.

doi:10.1080/14017431.2020.1762917

Cited by 15 publications

(16 citation statements)

References 19 publications

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“…An immunohistochemistry analysis of CM patients brain showed an accumulation of suPAR in macrophages/microglial cells in Durks granuloma adjacent to petechial haemorrhages, as well as in astrocytes, and in endothelial cells while the expression of suPAR was low in normal brains suggesting the association of suPAR expression with tissue damage of the blood brain barrier during CM [14,29,30]. High suPAR level was associated with disease severity and poor prognosis in cancers, CHD and infectious diseases including SARS-CoV-2 [31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin, Pentraxine 3, and Molecules of the Vascular Endothelium are Hallmark of Pathogenicity and Predict Coma and Mortality Among Children with Severe and Cerebral Malaria

Tornyigah

Blankson

Adamou³

et al. 2021

Preprint

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Background: Malaria-related deaths could be prevented if prompt diagnosis and prognostic biomarkers are available to allow rapid adequate treatment. Understanding of the mechanisms implicated in the progression from P. falciparum asymptomatic and uncomplicated malaria infections to severe life-threatening disease is necessary to identify such indicators. Methods: Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine 3, Ang-2, sTie-2, suPAR, sEPCR, and sICAM-1 in a cohort of 337 Beninese children who presented with pediatric malaria to investigate the potential association with clinical manifestations and outcomes. Results: The molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria. Plasmas concentrations of PTX3, PCT and the soluble receptors suPAR, sTie-2, sICAM-1 were significantly higher in children with deep coma as defined by a Blantyre Coma Score < 3 (P <0.001 for PTX3, suPAR, sTie-2, p=0.004 for PCT and p=0.005 for sICAM-1). Moreover, the concentrations of PTX3, suPAR and sEPCR were higher among children who died from severe malaria compared to those who survived with (p=0.037, p=0.035, and p=0.002 respectively).Conclusion: Our findings indicate the ability of these seven bioactive molecules to discriminate among the clinical manifestations of malaria and therefore, given their potential utility as prognostic biomarkers for severe and fatal malaria, they might be useful to improve severe cases management.

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Section: Discussionmentioning

confidence: 99%

Procalcitonin, Pentraxine 3, and Molecules of the Vascular Endothelium are Hallmark of Pathogenicity and Predict Coma and Mortality Among Children with Severe and Cerebral Malaria

Tornyigah

Blankson

Adamou³

et al. 2021

Preprint

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“…In addition to the uPA/suPAR binding which triggers the plasminogen activation system, suPAR also binds integrins and other receptors to activate different intracellular signaling pathways implicated in cell proliferation, invasion, angiogenesis and metastasis. suPAR has been described to be increased in cancers, in coronary heart diseases (CHD) and in infectious diseases including malaria [ 10 , 25 , 26 , 27 ]. An immunohistochemistry analysis of a CM patients brain showed an accumulation of suPAR in macrophages/microglial cells in Durks granuloma adjacent to petechial haemorrhages, as well as in astrocytes, and in endothelial cells [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria

Tornyigah

Blankson

Adamou³

et al. 2022

Diagnostics

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Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (p < 0.001 for Pentraxine-3, suPAR, and sTie-2, p = 0.004 for PCT, p = 0.005 for sICAM-1, p = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p < 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases.

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“…More recently, same authors found that the readmission rate within 30 days was higher in the suPAR group [16], in patients with low risk of serious illness in ED. Furthermore, Hodges et al sought to validate the (suPAR) for the prediction of death and MI, in a cohort of 1635 patients with suspected coronary artery disease [18]. They found that suPAR was independently associated with the combined endpoint of death/MI, cardiovascular death, and non-fatal MI.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of soluble urokinase plasminogen activator receptor in patients presenting to the emergency department with chest pain suggestive of acute coronary syndrome

Chenevier‐Gobeaux

Lemaréchal

Doumenc

et al. 2021

Clinical Biochemistry

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Introduction: Soluble urokinase plasminogen activator receptor (suPAR) is a prognostic biomarker of cardiovascular disease. Objectives: We aimed to evaluate the early prognostic value of suPAR in patients presenting to the emergency department (ED) with chest pain suggestive of acute coronary syndrome (ACS). Patients and methods: in a post-hoc analysis from a multicenter study including patients with a chest pain <6h, suPAR concentrations at ED admission were studied according to the outcome at 30-days. Results: 198 patients (median age 56 years) in whom 16% had an ACS, were included. Fifteen (7.3%) patients presented a 30-day event. At ED admission, median (IQR) suPAR concentrations were higher in patients with a 30-day event in comparison to patients without event (4.54 (3.09-8.61) vs. 2.72 (2.10-3.43) ng/mL, p<0.001). The ROC curve AUC of suPAR for the prediction of a 30-days event was 0.775 [95%CI: 0.710-0.831]. The optimal threshold was 3.3 ng/mL, with a sensitivity of 73 [45-92] % and a specificity of 72 [65-79] %. The association of a suPAR <3.3ng/mL AND a NT-proBNP <160 ng/L AND a HEART score <4 had a negative predictive value of 99 [91-100] %. A suPAR value at admission above 3.3 ng/mL was independently and significantly associated with a 30-day event in chest pain emergency patients ], p=0.015). Conclusion: suPAR is a promising biomarker for early prediction of events in chest pain emergency patients.

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SuPAR is associated with death and adverse cardiovascular outcomes in patients with suspected coronary artery disease

Cited by 15 publications

References 19 publications

Procalcitonin, Pentraxine 3, and Molecules of the Vascular Endothelium are Hallmark of Pathogenicity and Predict Coma and Mortality Among Children with Severe and Cerebral Malaria

Procalcitonin, Pentraxine 3, and Molecules of the Vascular Endothelium are Hallmark of Pathogenicity and Predict Coma and Mortality Among Children with Severe and Cerebral Malaria

Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria

Prognostic value of soluble urokinase plasminogen activator receptor in patients presenting to the emergency department with chest pain suggestive of acute coronary syndrome

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