“…Many examples abound in the literature on the use of hydrogels for the encapsulation and controlled release of proteins for therapeutic applications. Among the possible proteins to be released from hydrogels, the delivery of growth factors has been widely reported as a strategy to improve wound healing [64,76,130,131,132,133,134,135,136,137,138,139,140,141], release of bone morphogenetic protein 2 (BMP-2) has been used for bone regeneration [142,143,144,145,146,147,148,149,150,151,152], encapsulation of insulin has been explored for oral delivery and/or triggered release under various conditions [153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172], encapsulation of different antigens in hydrogels has been explored in order to enhance the immune response for vaccine boosting effects and other immunotherapies [173,174,175,176,177,178,179,180], and encapsulation of antibodies has been use in localized delivery applications [181,182,183,184]. These are just a few of the many applications that have been explored involving the encapsulation of biomolecules, but they serve to exemplify why h...…”