<sup>Irradiation of platelets in transfusion medicine: risk and benefit judgments</sup>

Hosseini, Ehteramolsadat; Kianinodeh, Fatemeh; Ghasemzadeh, Mehran

doi:10.1080/09537104.2021.1990250

Cited by 7 publications

(8 citation statements)

References 90 publications

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“…49,61 While ROS accumulation was not directly measured in this study, many of the quality parameters assessed are endpoint markers of ROS damage, including receptor shedding, degranulation, mitochondrial dysfunction and potentiation of aggregation. 50 Our results demonstrate that irradiation did not impact any of these parameters in the context of extended cold storage. However, the possibility remains that irradiation of cold-stored platelets may induce changes to parameters that were not examined in this study.…”

Section: Discussionmentioning

confidence: 53%

“…Furthermore, gamma irradiated platelets show evidence of greater oxidative stress than non‐irradiated components 49,61 . While ROS accumulation was not directly measured in this study, many of the quality parameters assessed are endpoint markers of ROS damage, including receptor shedding, degranulation, mitochondrial dysfunction and potentiation of aggregation 50 . Our results demonstrate that irradiation did not impact any of these parameters in the context of extended cold storage.…”

Section: Discussionmentioning

confidence: 55%

“…The negative effects of irradiation are reportedly exerted by damage to nuclear DNA, a direct deleterious effect on cell membrane integrity or through the accumulation of reactive oxygen species (ROS). 49,50 Irradiation appears to have little impact on the standard metabolic (pH, glucose, lactate) or activation (CD62P, annexin-V) parameters during conventional platelet storage. [15][16][17][18][19][20] However, given the membrane alterations initiated by cold storage, including cytoskeletal modifications, alteration in microtubules, and ultimately a significant morphological change, 48,51,52 it seemed plausible that irradiation of platelets that had undergone these coldinduced modifications may result in further detrimental changes to the platelets, especially during extended storage.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gamma and X‐ray irradiation do not affect the in vitro quality of refrigerated apheresis platelets in platelet additive solution (PAS‐E)

et al. 2022

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Background Platelet refrigeration (cold storage) provides the advantages of an extended shelf life and reduces the risk of bacterial growth, compared to platelets stored at room temperature (RT). However, processing modifications, such as irradiation, may further improve the safety and/or alter the quality of cold‐stored platelets. Platelet components are irradiated to prevent transfusion‐associated graft versus host disease (TA‐GvHD) in high‐risk patients; and while irradiation has little effect on the quality of RT‐stored platelet components, there is no data assessing the effect irradiation has following cold storage. Study Design and Methods Triple‐dose apheresis platelets were collected in 40% plasma/60% PAS‐E, using the TRIMA apheresis platform, and refrigerated (2–6°C) within 8 h of collection. On day 2, one of each component was gamma or X‐ray irradiated or remained non‐irradiated. Platelets were tested over 21 days. Results The platelet concentration decreased by approximately 20% in all groups during 21 days of storage (p > .05). Irradiation (gamma or X‐ray) did not affect platelet metabolism, and the pH was maintained above the minimum specification (>6.4) for 21 days. The surface phenotype and the composition of the supernatant was similar in non‐irradiated and irradiated platelets, regardless of the source of radiation. Functional responses (aggregation and clot formation) were not affected by irradiation. Discussion Gamma and X‐ray irradiation do not affect the in vitro quality of platelet components stored in the cold for up to 21 days. This demonstrates the acceptability of irradiating cold‐stored platelets, which has the potential to improve their safety for at‐risk patient cohorts.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gamma and X‐ray irradiation do not affect the in vitro quality of refrigerated apheresis platelets in platelet additive solution (PAS‐E)

et al. 2022

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“…Most of the products are irradiated with gamma rays or X-ray irradiators (25–50 Gy) to prevent GVHD and leukoreduction (leukocyte <1×10 6 /unit), except for granulocyte products [ 39 , 40 ]. The British Society of Hematology recommends that irradiated components should be continued until all the following criteria are met [ 41 ]:…”

Section: Blood Product and Irradiationmentioning

confidence: 99%

Transfusion support in hematopoietic stem cell transplantation

et al. 2023

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Transfusion support for hematopoietic stem cell transplantation (HSCT) is an essential part of supportive care, and compatible blood should be transfused into recipients. As leukocyte antigen (HLA) matching is considered first and as the blood group does not impede HSCT, major, minor, bidirectional, and RhD incompatibilities occur that might hinder transfusion and cause adverse events. Leukocyte reduction in blood products is frequently used, and irradiation should be performed for blood products, except for plasma. To mitigate incompatibility and adverse events, local transfusion guidelines, hospital transfusion committees, and patient management should be considered.

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The platelet storage lesion, what are we working for?

Liu,

Su,

Guo

et al. 2023

Clinical Laboratory Analysis

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BackgroundPlatelet concentrate (PC) transfusions are crucial in prevention and treatment of bleeding in infection, surgery, leukemia, and thrombocytopenia patients. Although the technology for platelet preparation and storage has evolved over the decades, there are still challenges in the demand for platelets in blood banks because the platelet shelf life is limited to 5 days due to bacterial contamination and platelet storage lesions (PSLs) at 20–24°C under constant horizontal agitation. In addition, the relations between some adverse effects of platelet transfusions and PSLs have also been considered. Therefore, understanding the mechanisms of PSLs is conducive to obtaining high quality platelets and facilitating safe and effective platelet transfusions.ObjectiveThis review summarizes developments in mechanistic research of PSLs and their relationship with clinical practice, providing insights for future research.MethodsAuthors conducted a search on PubMed and Web of Science using the professional terms “PSL” and “platelet transfusion.” The obtained literature was then roughly categorized based on their research content. Similar studies were grouped into the same sections, and further searches were conducted based on the keywords of each section.ResultsDifferent studies have explored PSLs from various perspectives, including changes in platelet morphology, surface molecules, biological response modifiers (BMRs), metabolism, and proteins and RNA, in an attempt to monitor PSLs and identify intervention targets that could alleviate PSLs. Moreover, novel platelet storage conditions, including platelet additive solutions (PAS) and reconsidered cold storage methods, are explored. There are two approaches to obtaining high‐quality platelets. One approach simulates the in vivo environment to maintain platelet activity, while the other keeps platelets at a low activity level in vitro under low temperatures.ConclusionUnderstanding PSLs helps us identify good intervention targets and assess the therapeutic effects of different PSLs stages for different patients.

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^{Irradiation of platelets in transfusion medicine: risk and benefit judgments}

Cited by 7 publications

References 90 publications

Gamma and X‐ray irradiation do not affect the in vitro quality of refrigerated apheresis platelets in platelet additive solution (PAS‐E)

Gamma and X‐ray irradiation do not affect the in vitro quality of refrigerated apheresis platelets in platelet additive solution (PAS‐E)

Transfusion support in hematopoietic stem cell transplantation

The platelet storage lesion, what are we working for?

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