<sup>99m</sup>Technetium-SESTAMIBI Uptake in Malignant Lymphomas. Correlation with Chemotherapy Response

Lazarowski, Alberto; Dupont, Juan; Fernández, J. Lobo; Garay, G; Florín, Alejo; Solimano, Jorge; Riveros, Dardo; Cacchione, Roberto

doi:10.1089/lrb.2006.4.23

Cited by 8 publications

(5 citation statements)

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“…99m Tc‐hexakis‐2‐methoxyisobutylisonitrile ( 99m Tc‐MIBI) is used as a myocardial perfusion imaging agent (Boucher et al, 1980). However, 99m Tc‐MIBI has been reported to be a transport substrate for P‐gp as not metabolized compound and it is used for in vivo functional detection of P‐gp in different tumors (Hendrikse et al, 1998; Lazarowski et al, 1999b; De Moerloose et al, 1999; Lazarowski et al, 2006b). The normal distribution of 99m Tc‐MIBI correlates with the active efflux mediated by P‐gp in excretory organs (Fig.…”

Section: Mtc‐mibi‐liver Clearance: a Kinetic Marker For Better Idementioning

confidence: 99%

ABC Transporters during Epilepsy and Mechanisms Underlying Multidrug Resistance in Refractory Epilepsy

et al. 2007

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Summary:It is estimated 20-25% of the epileptic patients fails to achieve good control with the different antiepileptic drugs (AEDs) treatments, developing refractory epilepsy (RE). Discovered first in cancer, the activity of P-glycoprotein (P-gp) and others ABC transporters as multidrug-resistance-associated proteins (MRPs) and breast cancer resistant protein (BCRP) are directly related with the refractoriness. We have observed the overexpression of these all transporters in the brain of patients with RE, and according with other authors, all these data suggests an active drug efflux from brain. Both constitutive and seizure induced brain P-gp overexpression was also suggested. As confirmation of these clinical evidences, different models of experimental epilepsy have demonstrated P-gp overexpression on blood brain barrier (BBB) and brain parenchyma cells, as astrocytes and neurons. In our model, early P-pg detection in vesselrelated cells and later additional P-gp detection in neurons, correlated with the gradual loss of protective effect of phenytoin. The progressive neuronal P-gp expression, depending on intensity and time-constancy of seizure-injury, was in agreement with the development of "P-gp-positive seizure-axis" proposed by Kwan & Brodie, who also showed that the development of RE directly correlated with the number and frequency of seizures before initiation of drug therapy. P-gp expression in excretory organs suggests that P-gp have a central role in drug elimination.Persistent low levels of AEDs in plasma and P-gp brain overexpression in several RE pediatric patients were reported. We also observed in adult RE patients, an increased liver clearance of 99m Tc-hexakis-2-methoxyisobutylisonitrile ( 99m Tc-MIBI) (a P-gp substrate), and the surgically treated cases showed Pgp brain overexpression. These results suggest the systemic hyperactivity of P-gp in RE patients, including brain P-gp overexpression should be suspected when persistent subtherapeutic levels of AEDs in plasma are detected. P-gp neuronal expression described in both clinical and experimental reports indicates that additional mechanisms could be operative from seizure-affected P-gp-positive neurons, due to AEDs targets are expressed at membrane level. An alternative mechanism was demonstrated in P-gp-expressed cells that exhibit lower membrane potential ( ψ 0 = −10 to -20) compared to normal physiological ψ 0 of -60 mV. Under this situation and irrespective to the P-gp pharmacoresistant property or type of drug treatment selected, P-gp-expressed neurons could increase their sensitivity to new seizures perhaps as an epileptogenic mechanism. The understanding of properties of these ABC transporters can offer new tools for better selection of more effective preventive or therapeutic strategies and avoid the invasive surgical treatments for RE. Key Words: Refractory epilepsy-MDR-BCRP-MVP99m Tc-MIBI.

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Section: Mtc‐mibi‐liver Clearance: a Kinetic Marker For Better Idementioning

confidence: 99%

ABC Transporters during Epilepsy and Mechanisms Underlying Multidrug Resistance in Refractory Epilepsy

et al. 2007

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“…Moreover, the uptake, washout rate, and retention of [ 99m Tc]Tc-MIBI could be helpful in the identification of drug resistance; patients with negative or decreased radiotracer activity tend to have unfavourable responses to chemotherapy compared to those with prominent radiotracer accumulation, irrespective of lymphoma type [2]. Also, a later scan (180 min after injection) could provide a more accurate prediction of chemoresistance than an early scan (30 min after injection) [3]. The involvement of bone marrow in multiple myeloma and correlation with in vitro and in vivo uptake was described by Fonti at al.…”

Section: Compliance With Ethical Standardsmentioning

confidence: 99%

Parathyroid imaging with [99mTc]Tc-MIBI SPECT/CT — unexpected findings of bone marrow involvement of non-Hodgkin’s lymphoma

Kunikowska

Królicki

2020

Endokrynologia Polska

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“…This functional phenotype can be inhibited by several P-gp and multidrug resistance modulators, such as PSC-833 and VX-710. Consequently, 99m Tc-SESTAMIBI tumor washout can be used as clear biomarker for drug-resistant phenotype in tumors [10,11].…”

Section: Opinionmentioning

confidence: 99%

P-Glycoprotein Expression in Heart, and its Potential Physiological Relevance

Lazarowski

2018

JOCCT

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^99mTechnetium-SESTAMIBI Uptake in Malignant Lymphomas. Correlation with Chemotherapy Response

Cited by 8 publications

References 14 publications

ABC Transporters during Epilepsy and Mechanisms Underlying Multidrug Resistance in Refractory Epilepsy

ABC Transporters during Epilepsy and Mechanisms Underlying Multidrug Resistance in Refractory Epilepsy

Parathyroid imaging with [99mTc]Tc-MIBI SPECT/CT — unexpected findings of bone marrow involvement of non-Hodgkin’s lymphoma

P-Glycoprotein Expression in Heart, and its Potential Physiological Relevance

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