<sup>99m</sup>Tc-Labeled Polyphosphate as a Skeletal Imaging Agent

Subramanian, G.; McAfee, John G.; Bell, Edward G.; Blair, Richard; O’Mara, Robert E.; Ralston, P. H.

doi:10.1148/102.3.701

Cited by 189 publications

(44 citation statements)

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“…Over the last thirty years, complexes of 99m Tc with bisphosphonate, such as methylene diphosphonate ( 99m Tc-MDP) and hydroxymethylene diphosphonate ( 99m Tc-HMDP), have been widely used as radiopharmaceuticals for the imaging of bone disorders such as metastatic bone disease, Paget's disease, osteoporotic fractures, etc [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent

Ogawa

Takai

Kanbara

et al. 2011

Nuclear Medicine and Biology

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Introduction:68 Ga is a radionuclide of great interest as a positron emitter for PET. To develop a new bone-imaging agent with radiogallium, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was chosen as a chelating site and Ga-DOTA complex-conjugated bisphosphonate, which has a high affinity for bone, was prepared and evaluated. Although we are interested in developing 68 Ga labeled bone imaging agents for PET, in these initial studies 67 Ga was used because of its longer half-life. Methods:DOTA-conjugated bisphosphonate (DOTA-Bn-SCN-HBP) was synthesized by conjugation of 2-(4-isothiocyanatebenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraac etic acid (p-SCN-Bn-DOTA) to 4-amino-1-hydroxybutylidene-1,1-bisphosphonate (alendronate).67 Ga-DOTA-Bn-SCN-HBP was prepared by coordination with 67 Ga, and its in vitro and in vivo evaluations were performed. Ogawa et al. 4/35 Results:67 Ga-DOTA-Bn-SCN-HBP was prepared with a radiochemical purity of over 95% without purification. 67 Ga-DOTA-Bn-SCN-HBP had great affinity for hydroxyapatite in binding assay. In biodistribution experiments, 67 Ga-DOTA-Bn-SCN-HBP accumulated in bone rapidly but was hardly observed in tissues other than bone. Pretreatment of an excess amount of alendronate inhibited the bone accumulation of 67 Ga-DOTA-Bn-SCN-HBP. Conclusions:67 Ga-DOTA-Bn-SCN-HBP showed ideal biodistribution characteristics as a bone-imaging agent. These findings should provide useful information on the drug design of bone-imaging agents for PET with 68 Ga. Ogawa et al. 5/35

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Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent

Ogawa

Takai

Kanbara

et al. 2011

Nuclear Medicine and Biology

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“…Based on the data of animal and human studies, 99m TC-MDP, unlike chelates (e.g. 99m TC-DTPA) which are handled byglomerular filtration [20,21], is probably excreted as simple phosphates by renal tubular [22]. Thus, accompany with sufficient excretory amount of MDP, it provides excellent images on kidney at the time of bone scanning, So 99m TC-MDP and 99m TC-DMSA examinations should be performed on different days.…”

Section: Discussionmentioning

confidence: 99%

“…The exponent I represents bone uptake and the exponent II, mainly is the renal excretion. It is generally agreed that the cumulative renal excretion up to 3 hours ranged between 30-50% [21,23,30]. So, by high resolution gamma cameras, we can visualize excellent renal image and dynamic derangement of urinary excretion at the time of bone scanning [20].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Efficacy of Bone Tracer 99mTC-MDP in Detecting Individual Renal Function Compared to Renal Cortical Imaging Agent 99mTC-DMSA

Hanafy¹,

Hamed²,

Elshafai³

2015

J Nucl Med Radiat Ther

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This study was performed to evaluate the usefulness of bone tracer 99m TC-MDP in detecting renal disorders by imaging of renal cortex for patients with cortical defect and estimation of split renal function (SRF) as compared with renal cortical imaging agent 99m TC-DMSA. In this study 23 patients (6 males, 17 females) with range age of 16y -75y (mean 45.6y ± 17.4y), and a total of 46 studies (using both 99m TC-DMSA and 99m TC-MDP per patient for left and right kidneys) were performed for detecting renal disorders. Both studies were performed within 48 hours between each other. SRF was calculated in all cases from renal uptake of the tracers into the region of interest by using computer acquired data of gamma camera. For detecting renal cortex abnormalities, all cortical scars and defects scars seen on 99m Tc-DMSA scan were also detected by 99m Tc-MDP.The results showed that the non visualized kidney on 99m TC-DMSA scan was also non visualized on 99m TC-MDP. Also, there was a high correlation between SRF values obtained from 99m TC-MDP and 99m TC-DMSA, where (p>0.01, r= 0.93 for left kidney and r=0.0.92 for right kidney).The similar SRF values of 99m TC-MDP and 99m TC-DMSA allow to use of 99mTC-MDP tracers for detecting both of bone and renal abnormalities.

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“…4), while free technetium (99mTcO4-) moves with a Rf value of about 0.7. Subramanian et al (1972) demonstrated that the acute toxicity level was 100mg of sodium polyphosphate per kg of body weight in mice and rabbits, and up to 10mg of polyphosphate per kg of body weight caused no disturbance in the serum calcium, phosphorous and alkaline phosphatase level in dogs. The maximum quantity of polyphosphate used in our clinical studies is 0.5mg/kg of body weight.…”

Section: Discussionmentioning

confidence: 99%

“…It is supposed that the polyphosphate within the complex may play important role in the skeletal localization of 99mTc-STPP. Another factor is the skeletal localization of carrier free tin (Subramanian et al 1972).…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of <sup>99m</sup>Tc-labeled Sodium Tripolyphosphate as a Bone Imaging Agent

Nakamura

Sawai

Abe

et al. 1973

Tohoku J. Exp. Med.

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^99mTc-Labeled Polyphosphate as a Skeletal Imaging Agent

Cited by 189 publications

References 0 publications

Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent

Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent

Evaluating the Efficacy of Bone Tracer 99mTC-MDP in Detecting Individual Renal Function Compared to Renal Cortical Imaging Agent 99mTC-DMSA

Clinical Evaluation of <sup>99m</sup>Tc-labeled Sodium Tripolyphosphate as a Bone Imaging Agent

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