<sup>99m </sup>TC HM‐PAO SPECT in Pediatric Migraine

Battistella, P. A.; Ruffilli, R.; Pozza, F; Pitassi, Isabella; Casara, Gianluca; Boniver, Clementina; Suppiej, Agnese; Bendagli, B.; Condini, A.

doi:10.1111/j.1526-4610.1990.hed3010646.x

Cited by 15 publications

(6 citation statements)

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“…After 6 months, SPECT was performed again on the same patients and signs of imaging improvement were observed. These findings suggest that some JSLE patients may present sub- (8,9,15,16). Reiff et al (9) studied 11 JSLE patients, all of them with active neurological disease, and observed SPECT alterations in 100% of cases.…”

Section: Discussionmentioning

confidence: 99%

Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus

Prismich

Hilário

Len

et al. 2002

Braz J Med Biol Res

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The objective of the present study was to identify the single photon emission computed tomography (SPECT) and magnetic resonance (MR) findings in juvenile systemic lupus erythematosus (JSLE) patients with CNS involvement and to try to correlate them with neurological clinical history data and neurological clinical examination. Nineteen patients with JSLE (16 girls and 3 boys, mean age at onset 9.2 years) were submitted to neurological examination, electroencephalography, cerebrospinal fluid analysis, SPECT and MR. All the evaluations were made separately within a period of 15 days. SPECT and MR findings were analyzed independently by two radiologists. Electroencephalography and cerebrospinal fluid analysis revealed no relevant alterations. Ten of 19 patients (53%) presented neurological abnormalities including present or past neurological clinical history (8/19, 42%), abnormal neurological clinical examination (5/19, 26%), and abnormal SPECT or MR (8/19, 42% and 3/19, 16%, respectively). The most common changes in SPECT were cerebral hypoperfusion and heterogeneous distribution of blood flow. The most common abnormalities in MR were leukomalacia and diffuse alterations of white matter. There was a correlation between SPECT and MR (P<0.05). We conclude that SPECT and MR are complementary and useful exams in the evaluation of neurological involvement of lupus.

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Section: Discussionmentioning

confidence: 99%

Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus

Prismich

Hilário

Len

et al. 2002

Braz J Med Biol Res

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“…17 Pain was more side concordant with the EEG findings (Nos. 7,9,11,20, and 28) than with SPECT abnormalities (Nos. 8, 9, and 11).…”

Section: And In Half Of the Cases Reported By Spina And Colleagues 12mentioning

confidence: 93%

“…9 Lastly, there are no studies in juvenile migraine without aura performed in accordance with the latest classification. 13 The only available data from two studies in pediatric subjects suffering from "common" migraine show normal findings in all cases studied by Battistella et al 11…”

Section: Commentsmentioning

confidence: 94%

“…In the two earlier studies, the authors, used the Ad Hoc Committee criteria, 15 thereby including clinical entities such as "classical," "hemiplegic," and "basilar artery" migraine. 11,12 Therefore, the interictal SPECT findings in juvenile migraine with aura are not homogeneous because the classification methods were different and only a few patients have been analyzed Conversely, also in studies performed with the same tracer in adults, hypoperfused 6,7 of hyperperfused1 areas have been found in classical and/or hemiplegic migraine, mainly in the posterior regions. Using other tracers in adults during the interictal period, rCBF asymmetries have been revealed in migraine with aura 3 and rCBF reductions in migraine accompagnee, but not in classical migraine.…”

Section: Commentsmentioning

confidence: 99%

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Interictal and Ictal Phase Study With Tc 99m HMPAO Brain SPECT in Juvenile Migraine With Aura

Soriani¹,

Feggi²,

Battistella³

et al. 1997

Headache

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Single photon emission computed tomography (SPECT) was performed on 30 juvenile patients suffering from different types of migraine with aura. SPECT was carried out only during the pain-free interval in 11 patients. The other 19 patients underwent SPECT ictally and 9 of them also interictally. During the pain-free interval, the investigation was normal in 16 of 20 cases and revealed hypoperfused areas in 4 of 20 cases. Ictally, regional cerebral blood flow (rCBF) abnormalities were found in 14 of 19 cases; hypoperfusion in 11 patients and hyperperfusion in 3 patients. In most cases, rCBF abnormalities corresponded to the topography of neurologic symptoms. Our interictal period results do not agree with the previous studies in juvenile migraineurs, while during the ictal phase we demonstrated, for the first time, significant rCBF abnormalities in juvenile patients suffering from migraine with aura.

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“…The aura appears during focal oligemia (21 ), and the focal neurological symptoms seem to correlate with the side of the hypoperfusion in both adults and children (22). After headache onset, the rCBF gradually increases to the hyperperfusion range.…”

Section: Vascular Phenomenamentioning

confidence: 99%

Pathophysiology of Headaches with a Prominent Vascular Component

Pareja

White

Sjaastad

1996

Pain Research and Management

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Vascular changes, whether preliminary or secondary, seem to accompany most headaches. The literature concerning pathophysiological mechanisms in headaches where vascular phenomena are a major, integral part, ie, migraine and cluster headache syndrome, is reviewed and the most common forms of headache associated with cerebrovascular disease are discussed. Emphasis is placed on the vascular phenomena and on the abundant hypotheses and theories regarding headache mechanisms. This review also presents alternative explanatory models, and compares the available anatomical, physiological and biochemical results.

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^99mTC HM‐PAO SPECT in Pediatric Migraine

Cited by 15 publications

References 4 publications

Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus

Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus

Interictal and Ictal Phase Study With Tc 99m HMPAO Brain SPECT in Juvenile Migraine With Aura

Pathophysiology of Headaches with a Prominent Vascular Component

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99m TC HM‐PAO SPECT in Pediatric Migraine

Cited by 15 publications

References 4 publications

Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus

Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus

Interictal and Ictal Phase Study With Tc 99m HMPAO Brain SPECT in Juvenile Migraine With Aura

Pathophysiology of Headaches with a Prominent Vascular Component

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^99mTC HM‐PAO SPECT in Pediatric Migraine