<sup>68</sup>Ga-adsorption on the Si-nanoparticles

Skrabkova, Hanna S.; Bubenschikov, Victor; Кодина, Г. Е.; Lunev, A. S.; Ларенков, А. А.; Эпштейн, Наталья Борисовна; Kabashin, Andrei V.

doi:10.1088/1757-899x/487/1/012026

Cited by 4 publications

(2 citation statements)

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“…For instance, laser-induced incorporation of different types of radionuclides (RNs) can add new modalities to laser-synthesized nanostructures such as diagnostic and/or therapeutic one by choosing an appropriate type of elements ( Figure 8 ). It can considerably facilitate the formation of radionuclide nanocarriers for nuclear nanomedicine that are currently performed by complexed chemical methods [ 74 , 75 ] where RNs can play a dual role (both diagnostics and therapeutic), locally detecting or treating a malignant tumour. Together with surfactant-free synthesis allowing chemical composition variation, such ultrapure multicomponent nanoagents can play a very important role in many biomedical applications such as bioimaging, biosensing, hyperthermia, nuclear medicine, photodynamic, and radio-therapy of cancer ( Figure 8 ) [ 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

et al. 2023

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Plasmonic nanostructures have attracted a broad research interest due to their application perspectives in various fields such as biosensing, catalysis, photovoltaics, and biomedicine. Their synthesis by pulsed laser ablation in pure water enables eliminating various side effects originating from chemical contamination. Another advantage of pulsed laser ablation in liquids (PLAL) is the possibility to controllably produce plasmonic nanoparticles (NPs) in combination with other plasmonic or magnetic materials, thus enhancing their functionality. However, the PLAL technique is still challenging in respect of merging metallic and semiconductor specific features in nanosized objects that could significantly broaden application areas of plasmonic nanostructures. In this work, we performed synthesis of hybrid AuSi NPs with novel modalities by ultrashort laser ablation of bulk gold in water containing silicon NPs. The Au/Si atomic ratio in the nanohybrids was finely varied from 0.5 to 3.5 when changing the initial Si NPs concentration in water from 70 µg/mL to 10 µg/mL, respectively, without requiring any complex chemical procedures. It has been found that the laser-fluence-insensitive silicon content depends on the mass of nanohybrids. A high concentration of paramagnetic defects (2.2·× 1018 spin/g) in polycrystalline plasmonic NPs has been achieved. Our findings can open further prospects for plasmonic nanostructures as contrast agents in optical and magnetic resonance imaging techniques, biosensing, and cancer theranostics.

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Section: Discussionmentioning

confidence: 99%

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

et al. 2023

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“…Tests of rat survival showed excellent therapeutic effect, with 72% of treated rats surviving, while none of the untreated (control) animals survived (Figure ). In a separate work, we studied conjugation of Si nanoparticles with radioactive 68 Ga for PRT imaging. , Recently, Torresan et al prepared iron–boron nanoparticles by laser-assisted synthesis for MRI-guided BCNT …”

Section: Recent Approaches and Conceptsmentioning

confidence: 99%

Transforming Nuclear Medicine with Nanoradiopharmaceuticals

et al. 2022

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Nuclear medicine is expected to make major advances in cancer diagnosis and therapy; tumor-targeted radiopharmaceuticals preferentially eradicate tumors while causing minimal damage to healthy tissues. The current scope of nuclear medicine can be significantly expanded by integration with nanomedicine, which utilizes nanoparticles for cancer diagnosis and therapy by capitalizing on the increased surface area-to-volume ratio, the passive/active targeting ability and high loading capacity, the greater interaction cross section with biological tissues, the rich surface properties of nanomaterials, the facile decoration of nanomaterials with a plethora of functionalities, and the potential for multiplexing several functionalities within one construct. This review provides a comprehensive discussion of nuclear nanomedicine using tumor-targeted nanoparticles for cancer radiation therapy with either pre-embedded radionuclides or nonradioactive materials which can be extrinsically triggered using various external nuclear particle sources to produce in situ radioactivity. In addition, it describes the prospect of combining nuclear nanomedicine with other modalities to enable synergistically enhanced combination therapies. The review also discusses advances in the fabrication of radionuclides as well as describes laser ablation technologies for producing nanoradiopharmaceuticals, which combine the ease of production with exceptional purity and rapid biodegradability, along with additional imaging or therapeutic functionalities. From a practical standpoint, these attributes of nanoradiopharmaceuticals may provide distinct advantages in diagnostic/therapeutic sensitivity and specificity, imaging resolution, and scalability of turnkey platforms. Coupling image-guided targeted radiation therapy with the possibility of in situ activation of nanomaterials as well as combining with other therapeutic modalities using a multifunctional nanoplatform could herald an era of exciting technological and therapeutic advances to radically transform the landscape of nuclear medicine. The review concludes with a discussion of current challenges and presents the authors’ views on future opportunities to stimulate further research in this rewarding field of high societal impact.

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Determination of ionic 68Ga impurity in radiopharmaceuticals: major revision of radio-HPLC methods

Maruk

Ларенков

2019

J Radioanal Nucl Chem

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⁶⁸Ga-adsorption on the Si-nanoparticles

Cited by 4 publications

References 15 publications

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

Transforming Nuclear Medicine with Nanoradiopharmaceuticals

Determination of ionic 68Ga impurity in radiopharmaceuticals: major revision of radio-HPLC methods

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68Ga-adsorption on the Si-nanoparticles

Cited by 4 publications

References 15 publications

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

Transforming Nuclear Medicine with Nanoradiopharmaceuticals

Determination of ionic 68Ga impurity in radiopharmaceuticals: major revision of radio-HPLC methods

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⁶⁸Ga-adsorption on the Si-nanoparticles