64Cu tumor labeling with hexadentate picolinic acid‐based bispidine immunoconjugates
Manja Kubeil,
Christin Neuber,
Miriam Starke
et al.
Abstract:Discussed are two picolinate appended bispidine ligands (3,7‐diazabicyclo[3.3.1]nonane derivatives) in comparison with an earlier described bis‐pyridine derivative, which are all known to strongly bind CuII. The radiopharmacological characterization of the two isomeric bispidine complexes includes quantitative labeling with 64CuII at ambient conditions with high radiochemical purities and yields (molar activities > 200 MBq/nmol). Challenge experiments in presence of EDTA, cyclam, human serum and SOD demonst… Show more
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