³¹P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients

Abstract

ABSTRACT:Background: Differences in brain energy metabolism have been found between migraine

Magnetic resonance spectroscopy in migraine: What have we learned so far?

“…One study, Boska et al, reported only a depletion of PCr in anterior brain regions of MwA and the occipital cortex of FHM patients (11). The calculated value of the phosphorylation potential was significantly decreased in migraine patients, as reported in a number of studies (8,9,(12)(13)(14)(15) hence has a lower energy reserve, was also frequently observed (8,9,(13)(14)(15)18). The percentage of v/v max was found to be significantly increased in migraine patients (8,9,14,15).…”

“…Attack-free intervals ranged from 48 hours (12,27,30,31) to a few days (11,28,34,49), from a week (5-7, 10, 14) to more than a week (17,19,20,23,39). In all other studies no information concerning the attack-free period is specified (8, 9, 13, 15, 16, 18, 24, 36, 37, 45, 48, 54).…”

“…The variability in the MRS data reflects a combination of true variation between study subjects and experimental variation, which mainly arises from the signal-to-noise ratio of the acquired spectra. It is possible that the signal-to-noise ratio, in particular in 31 (11,12). In a few studies information concerning coil specification was lacking (37)(38)(39)49).…”

Diagnosis, pathophysiology and management of chronic migraine: a proposal of the Belgian Headache Society

“…It is generally accepted that the common forms of migraine with or without aura (Table 2): abnormal thickness, connectivity and/or activation of certain cortical and subcortical areas [24][25][26][27], increased transmitter [28] or iron content [29][30][31], decreased ATP content [32,33] and an abnormal pattern of sensory processing [34,35]. The latter is characterized by low amplitude of initial responses and hyperresponsivity with lack of habituation of late responses during repeated sensory stimuli [36], and has been attributed to a thalamocortical dysrhythmia caused by deficient monoaminergic control by brain stem nuclei (review in [37]).…”

31P‐MRS in Migraine: Fallen Through the Cracks

“…In a recent 31 P-MRS study at 3 Tesla using an absolute quantification technique, a significant decrease was observed in both high-energy phosphates, PCr and ATP, in the occipital lobe of migraine without aura patients compared with normal controls. 5 The depletion of brain high-energy phosphates in steady state measurements reflects an imbalance between ATP production and ATP use in migraine patients, and suggests that the brain of migraine patients is compromised to deal with metabolic stress.…”