[ ³ H]Morphine Localization in Myenteric Plexus

Abstract

Preferential binding of 3H-labeled morphine to satellite cells, but not to large neurons in the myenteric plexus, is demonstrated autoradiographically. Microfluorometric spectra of the plexus show nerve fibers that contain norepinephrine and impinge on satellite cells. Cells containing serotonin occur occasionally on longitudinal muscle outside the myenteric plexus.

The Mechanism of Action of Narcotic Analgesics in the Guinea‐pig Ileum

“…Our supposition that the morphine-sensitive cells are the cholinergic efferents to the muscle is at variance with the interpretation by Diab, Dinerstein, Watanabe & Roth (1976) of their autoradiographic experiments. They found the PHI-morphine bound to a population of small cells in the myenteric plexus.…”

“…They found the PHI-morphine bound to a population of small cells in the myenteric plexus. Diab et al (1976) referred to these cells as satellite cells but presented no ultrastructural evidence for such an identification. There are two reasons why the cells which they found to bind P3HI-morphine might be neurones rather than glial cells.…”

Inhibitory synaptic potentials resulting from alpha 2‐adrenoceptor activation in guinea‐pig submucous plexus neurones.

“…but had no lasting effect on the fast or slow e.p.s.p.s. The previous suggestion by Hirst & Silinsky (1975) that dopamine and noradrenaline may be equally likely candidates appears untenable in the light of more recent studies which have shown a virtual absence of dopamine within intestinal nerves (Diab, Dinerstein, Watanabe & Roth, 1976;Furness & Costa, 1980, 1982.…”

THE EFFECT OF CORTICOSTEROID PRETREATMENT IN VIVO ON THE CONTRACTION OF GUINEA‐PIG ILEUM AND DUODENUM

“…Furthermore, the presence of opiate receptors has been demonstrated in the myenteric plexus of guinea-pig ileum (Diab et al 1976).…”

“…Endogenous opioids are known to be produced and secreted by several tissues of the body such as the small intestine (Goldstein 1973;Smith et al 1976;Polak et al 1977), adrenal medulla (Viveros et al 1979) and pituitary gland (Mains et al 1977;Roberts & Herbert 1977;Khalid et al 1982). Furthermore, the presence of opiate receptors has been demonstrated in the myenteric plexus of guinea-pig ileum (Diab et al 1976).…”