²⁹Si and ¹³C NMR spectra of trimethylsilylated amino acids

Long-range two-dimensional1H-29Si heteronuclear shift correlation using gradients. Application to tetra-TMS-?-O-methyl-D-glucopyranose and tetra-TES-?-O-methyl-D-glucopyranose

“…29 Si NMR spectroscopy has proved to be a very efficient method for studying silylation reactions in organic chemistry. 16,17 Surprisingly, very few papers have reported the use of two-dimensional techniques, 4 -7 although they could be very efficient in the study of protection/deprotection reactions when a large number of possible silylation sites are present in a molecule (e.g. Therefore, it is difficult to use 1 H and 13 C NMR to prove unambiguously the site of silylation/desilylation in organic molecules.…”