Abstract:Acyl glucuronides (AGs) are common metabolites of carboxylic
acid-containing
compounds. In some circumstances, AGs are suspected to be involved
in drug toxicity due to formation of acyl migration products that
bind covalently to cellular components. The risk of this adverse effect
has been found to be correlated with the chemical stability of the
AG, and assays have been described that monitor acyl migration by
liquid chromatography coupled with mass spectrometry (LC-MS). This
analysis can be challenging as it… Show more
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