<sup>18</sup>F Uptake Within Metastatic Osteosarcoma of the Liver

O’Mara, Robert E.; Brettner, Alfred; Danigelis, James A.; Gould, Leo V.

doi:10.1148/100.1.113

Cited by 19 publications

(5 citation statements)

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“…O’Mara et al ,4 Shapiro et al 5 and Daw et al 6 report cases of osteosarcoma with metastatic lesion to the liver with or without simultaneous pulmonary metastases. Dalinka et al 7 describe a case of extraskeletal osteosarcoma (a primary osteosarcoma in the kidney) with metastasis to the liver.…”

Section: Discussionmentioning

confidence: 99%

Metastatic osteosarcoma to the liver and the kidney: a case report and review of the literature

Yu¹,

Yao²

2009

Case Reports

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Improvements in multimodal treatment for osteosarcoma, especially in the use of adjuvant chemotherapy, have increased event-free and overall survival. Meanwhile, the prolonged survival of patients has permitted the appearance of new, significant, extrapulmonary targets for metastasis. Here we report a middle-aged adult with osteosarcoma who developed hepatic and renal metastases 4 months after the diagnosis of osteosarcoma. Chemotherapy and radiofrequency ablation were performed. CT scan has shown that the metastatic lesion has stabilised in the liver and kidney in the latest follow-up. This suggests that early multimodal treatment may improve both the survival rate and the quality of life of osteosarcoma patients with extrapulmonary metastases.

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Section: Discussionmentioning

confidence: 99%

Metastatic osteosarcoma to the liver and the kidney: a case report and review of the literature

Yu¹,

Yao²

2009

Case Reports

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“…Less frequent lesions cited include endocrine tumor of the pancreas [12], leiomyosarcoma [13], malignant melanoma [3], cancer of the ovary [1], lymphoma [14], osteosarcoma [15], pleural mesothelioma [16], neuroblastoma [17], and breast cancer [2,11].…”

Section: Discussionmentioning

confidence: 99%

“…Another method for detecting this type of metastatic evolution is use of 18F [15]; Garcia et al [10] have presented cases of calcified metastases with build-up of bone-seeking radionuclides in the liver, but the precise mechanism behind this nonskeletal accumulation is unknown. Finally, Bernardino [11] has discussed the use of CT scans in connection with calcified hepatic metastases.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic study of calcified hepatic metastases: A report of 13 cases

Bruneton

Ladrée²,

Caramella

et al. 1982

Gastrointest Radiol

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Thirteen cases of calcified metastases were discovered by u l t r a s o n o g r a p h y in cancer patients undergoing chemotherapy. Plain films revealed calcifications in only 9 of these 13 cases; CT scans confirmed the u l t r a s o n o g r a p h i c findings in the remaining 4 cases. A l t h o u g h calcification of a metastasis corresponds to at least partial involution, it is always associated with a polymetastatic hepatic condition, and detection of a calcified metastasis therefore does not affect the prognosis.Key words: Hepatic metastases -U l t r a s o n o g r a p h y -Liver calcification C o m p u t e d t o m o g r a p h y .A l t h o u g h liver metastases constitute the most frequent type of liver tumors, they are only rarely calcified. Various publications have dealt with the radiologic aspects as seen on X-rays of the a b d o m e n without p r e p a r a t i o n [1-4], but we found only one p u b l i c ation, limited to 3 cases, concerning the echographic aspects o f calcified metastases [5]. In 1979 Bernardino and Green [6] discussed the surveillance of hepatic metastases during chemotherapy, but they did not mention the possibility of calcifications. We therefore felt it interesting to present our 13 personal observations of calcified liver metastases. Material and MethodsOf a population of 800 patients with hepatic metastases, 300 on chemotherapy were entered in our study. Ultrasonography revealed calcifications in one or more hepatic metastases in 13 cases (8 men, 5 women). These patients' primary cancers included adenocarcinoma of the colon (10), breast cancer (1), Ewing's tumor (1), and thyroid cancer (1). Real-time echography was followed by contact Address reprint requests to: J.N. Bruneton, M.D., Department of Radiology, Centre A. Lacassagne, 36 Voie Romain 06054 Nice Cedex, France scanning using 2.25-5 MHz transducers, depending on the patient's morphotype.In all instances where sonographic findings pointed toward calcifications, a plain film was taken. When radiologic films proved negative, a CT scan was obtained (4 cases). Existence of hepatic metastases was demonstrated anatomically in all 13 cases. Except for 1 case, all patients were followed up by echography, and all had undergone at least 2 other echographic examinations prior to discovery of calcifications within metastases. All patients were on chemotherapy. ResultsThe hepatic calcifications in all 13 cases showed as a large, highly echoic zone with an acoustic shadow behind (Figs.1 3). Other metastatic lesions were found in all patients (hyperechoic in 12 cases, hypoechoic in 1 case). Necrotic metastases in another area o f the liver were also noted in 5 patients.Plain films revealed occasionally hard-to-see heterogenic images o f calcification in only 9 cases (Fig. 4). In the 4 cases in which radiologic films were Fig. 1. Sagittal scan of the liver : hyperechoic pattern with acoustic shadow. Note a bull's-eye metastasis in the inferior part of the right lobe 0364-2356/82/0007-0061 $01.00 9 1982 Springer-Verlag New Y o r k Inc.62 J....

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“…Postmortem examination of 54 patients with osteosarcoma detected pulmonary metastases in all but one (98%), bone metastases in 20 (37%), and liver metastases in 9 (16.7%) [4]. There have been 2 case reports of primary osteosarcoma with hepatic metastases [5,6]; metastasis was possibly present at the time of diagnosis in one case [6]. Here we report the occurrence of hepatic metastases at the time of diagnosis of a secondary osteosarcoma after treatment for synovial sarcoma.…”

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confidence: 80%

METASTATIC OSTEOSARCOMA TO THE LIVER AFTER TREATMENT FOR SYNOVIAL SARCOMA: A Case Report

Daw

Kaste

Hill

et al. 2001

Pediatric Hematology and Oncology

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Metastatic osteosarcoma most commonly affects the lungs and other bones. Hepatic metastasis at the time of diagnosis is extremely rare. A 14-year-old boy with synovial sarcoma of the left popliteal fossa was treated with surgical resection, radiotherapy for microscopic residual disease, and 1 year of chemotherapy (vincristine, cyclophosphamide, dactinomycin, and doxorubicin). Approximately 10 years after the initial diagnosis, a secondary osteosarcoma developed in the left proximal tibia. Computed tomography at presentation showed bilateral pulmonary metastases and large ossified nodules in the liver that demonstrated abnormal avidity on 99mTc MDP bone scan indicating hepatic metastasis. Despite chemotherapy (cisplatin, ifosfamide, high-dose methotrexate, and dacarbazine), the patient died of progressive disease 4 months after the diagnosis of the second cancer. Hepatic metastasis was found at the time of diagnosis of a secondary osteosarcoma and manifested as ossified nodules. The risk of radiation-induced osteosarcoma should always be considered in decisions about treatment for soft-tissue sarcoma.

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¹⁸F Uptake Within Metastatic Osteosarcoma of the Liver

Cited by 19 publications

References 6 publications

Metastatic osteosarcoma to the liver and the kidney: a case report and review of the literature

Metastatic osteosarcoma to the liver and the kidney: a case report and review of the literature

Ultrasonographic study of calcified hepatic metastases: A report of 13 cases

METASTATIC OSTEOSARCOMA TO THE LIVER AFTER TREATMENT FOR SYNOVIAL SARCOMA: A Case Report

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18F Uptake Within Metastatic Osteosarcoma of the Liver

Cited by 19 publications

References 6 publications

Metastatic osteosarcoma to the liver and the kidney: a case report and review of the literature

Metastatic osteosarcoma to the liver and the kidney: a case report and review of the literature

Ultrasonographic study of calcified hepatic metastases: A report of 13 cases

METASTATIC OSTEOSARCOMA TO THE LIVER AFTER TREATMENT FOR SYNOVIAL SARCOMA: A Case Report

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¹⁸F Uptake Within Metastatic Osteosarcoma of the Liver