[¹⁸F]Fluorodeoxyglucose Uptake by Positron Emission Tomography Predicts Outcome of Non–Small-Cell Lung Cancer

Abstract

The SUV of the primary tumor was the strongest prognostic factor among the patients treated by curative surgery or radiotherapy.

Prognostic stratification using F-18 FDG PET/CT in patients with advanced stage (Stage III and IV) non-small cell lung cancer

“…A number of studies suggested that F-18 FDG PET had a prognostic value in NSCLC patients [16][17][18][19][20]. Most of these studies evaluated SUV in primary tumor before and after treatment and they founded that FDG uptake in primary tumor could predict overall survival with different thresholds of SUV.…”

Metabolic Characteristics of Advanced Biliary Tract Cancer Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Their Clinical Implications

“…The extent of uptake of 18 F-FDG by a cancer, which usually correlates with the degree of tumor proliferation and metabolism, is evaluated by a semiquantitative measurement, the standardized uptake value (SUV) [10]. The prognostic significance of 18 F-FDG uptake, measured using the maximal standardized uptake value (SUV max ), has been evaluated in lung, endometrial, cervical, and renal cell carcinomas [11][12][13][14][15][16][17][18]. Studies of the clinical significance of metabolic activity in advanced biliary tract cancers are limited.…”

Primary Tumor Maximum Standardized Uptake Value Measured on18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Is a Prognostic Value for Survival in Bile Duct and Gallbladder Cancer

“…16,22 In mass-forming IBDC, the disease-free survival of patients with a high primary tumor SUV was significantly worse than those with a low SUV. 16 Although we have no more detailed information for postoperative recurrence in our study, recurrence might be a contributory factor of poor survival.…”

“…In lung cancer, breast cancer, malignant lymphoma, endometrial cancer and early cervical cancer, studies showed that primary tumor SUVmax on FDG-PET was an independent and significant prognostic value on multivariate analysis. [11][12][13][21][22][23] A similar study evaluated the correlation between FDG uptake and prognosis for patients with bile duct and gallbladder cancer. 14 The results showed that high SUVmax was associated with poor overall survival on univariate analysis but was not independently associated with prognosis on multivariate analysis.…”

“…Some authors reported that a high SUVmax of primary tumors is significantly related to higher stage in various cancers. 12,22,23,25 In bile duct cancer, one study reported a significant association between high SUVmax and advanced pathologic stage. 14 In this study, the pathologic stage was also independently associated poor overall survival in multivariate analysis.…”