[¹⁸F]Fluorodeoxyglucose Positron Emission Tomography Is More Sensitive Than Skeletal Scintigraphy for Detecting Bone Metastasis in Endemic Nasopharyngeal Carcinoma at Initial Staging

Abstract

[18F]FDG PET is more sensitive than SS for detecting bone metastasis in endemic NPC at initial staging, whereas SS can be considered as supplementary in this setting.

Meta-analysis of diagnostic value of 18F-FDG PET or PET/CT for detecting lymph node and distant metastases in patients with nasopharyngeal carcinoma

“…After reviewing the title and abstract, we excluded 556 obviously irrelevant articles. For the remaining 99 articles, we read full texts, and 18 articles 10,12,14,15,[19][20][21][22][23][24][25][26][27][28][29][30][31][32] consisting 20 studies fulfilled all inclusion criteria and were included for data analysis.…”

“…There were 7 studies for N staging and 13 studies for M staging. Eight articles 10,14,15,23,[25][26][27]32 certainly enrolled patients prospectively, and the other study designs were retrospective. Obviously, most studies were performed in Asia, especially in China.…”

Plasma Epstein‐Barr virus DNA screening followed by 18F‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography in detecting posttreatment failures of nasopharyngeal carcinoma

“…Conventional workups, including physical examinations, endoscopy, computerized tomography (CT) scans, magnetic resonance imaging (MRI), chest radiography, whole-body bone scans, and abdominal sonography, have limited sensitivity and specificity in the early diagnosis of recurrent NPC. Recently, functional imaging with 18 F-fluoro-2-deoxy-D-glucose ( 18 F-FDG) positron emission tomography (PET) scans or PET/CT scans has demonstrated encouraging efficacy in NPC staging, [1][2][3][4][5][6] response evaluation, [7][8][9] and relapse detection. [10][11][12][13] Another important advance in NPC is the quantification of plasma EBV DNA with real-time quantitative polymerase chain reaction (rt-qPCR), which reportedly is a useful tool for the detection, monitoring, and prognostic prediction in NPC.…”

Detection of hematogenous bone metastasis in cervical cancer

“…18 18 F-FDG-PET has been considered useful for detecting active bone metastasis in breast, lung, and head and neck cancers. [6][7][8]19,20 In cervical cancer, 18 F-FDG-PET or PET/CT has detected unsuspected bone metastasis. 21,22 However, to our knowledge, no large-scale study has been performed to compare the performances of 18 F-FDG-PET and CT or MR imaging in patients with cervical cancer.…”

“…Both MR and PET are considered to have high sensitivity for detecting bone marrow or osteolytic bone metastasis. [6][7][8][9][10][11] Because hematogenous bone metastasis is considered to start in the bone marrow, and the majority of metastatic bone lesions in cervical cancer seem to be of an osteolytic nature, 12 both MR imaging and PET may facilitate the detection of bone metastasis. To the best of our knowledge, no study had been conducted to evaluate the diagnostic performances of CT, MR imaging, and PET in detecting hematogenous bone metastasis in patients with invasive cervical cancer.…”