R ecent publications have described several brain abnormalities in patients with coronavirus disease 2019 (COVID-19), such as cerebral hemorrhage (including intraparenchymal hemorrhage or diffuse microhemorrhage), cerebral infarction, leukoencephalopathy, 1,2 leptomeningeal enhancement, circumscribed or diffuse white matter signal abnormalities, posterior reversible encephalopathy syndrome, and focal intraparenchymal enhancement. 3,4 In the [ 18 F] FDG-PET/CT, several patterns of abnormalities have been described, including frontal hypometabolism and cerebellar hypermetabolism 5 and diffuse cortical hypometabolism (associated with putaminal and cerebellum hypermetabolism, compatible with encephalitis, and especially cerebellitis). 6,7 In most of the cases, the underlying pathophysiological mechanism remains unknown.Arterial spin-labeling (ASL) is increasingly used in neuroradiology as a diagnostic aid. 8,9 Hyperperfusion is associated with hypermetabolism in PET/CT, suggesting that ASL could be considered as an alternative to [ 18 F] FDG-PET/CT. 10 In the current brief, we report a new neuroradiological finding on MR imaging and PET/CT in patients with COVID-19.