<sup>131</sup>I therapy for 345 patients with refractory severe hyperthyroidism: Without antithyroid drug pretreatment

Ding, Yong; Xing, Jihong; Fang, Yi; Wang, Yong; Zhang, Youren; Long, Youming

doi:10.1177/1535370215602784

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…Besides, no signs of disease relapse and recurrence were observed in patients treated with iodine alone. This study concluded that utilizing iodine therapy alone is safe and effective in treating patients with severe hyperthyroidism who are resistant to anti-thyroid drugs 41 . Similarly, our results have shown that administrating iodine therapy alone is safe in patients with thyrotoxicosis and, in terms of adverse effects, is similar to the combination therapy of drug and iodine therapy.…”

Section: Discussionmentioning

confidence: 84%

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Effect of iodine-therapy on hyperthyroidism patients without pre-administration of anti-thyroid therapeutic options

Rashidi

Ghaderian

Sedaghat

et al. 2022

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Anti-thyroid treatment and radioiodine are mainly used treatments for patients with thyrotoxicosis. The effect of anti-thyroid drugs (ATDs) on radioactive iodine's therapeutic effectiveness in hyperthyroidism remains controversial. This study aimed to determine the treatment effectiveness and complications in patients with thyrotoxicosis receiving radioiodine treatment with or without adjunctive anti-thyroid drugs in a tertiary endocrinology center in Ahvaz, Iran. A total of 165 patients with thyrotoxicosis (50 males and 115 females) were recruited in this retrospective clinical study. These patients were divided into two groups: one group underwent natural iodine therapy without being treated with anti-thyroid drugs (N= 86), and the other group was first treated with anti-thyroid drugs and then treated with iodine (N= 79). Then, the frequency of euthyroidism, thyroid storm, thyroiditis, hypothyroidism and the time to reach euthyroidism is evaluated. The results showed no difference between the two groups when reaching the euthyroid and the mean numerical mean TSH at the time of hypothyroidism. However, the average dose of iodine received in the concomitant drug group was lower. No thyroid storm was observed in the two groups regarding complications after treatment. Also, the prevalence of hypothyroidism and thyroiditis were not significantly different between the two groups. Iodine therapy with and without the use of anti-thyroid drugs (ATD) in low-risk patients with thyrotoxicosis has no difference in treatment outcomes, response to treatment, and subsequent complications.

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Section: Discussionmentioning

confidence: 84%

“…Ding et al 41 conducted a study to evaluate long-term outcomes and immunity of iodine therapy without drug therapy. In their study, of 408 patients, 283 individuals were treated with iodine therapy, 15 of whom achieved complete remission and 47 partial remissions.…”

Section: Discussionmentioning

confidence: 99%

Effect of iodine-therapy on hyperthyroidism patients without pre-administration of anti-thyroid therapeutic options

Rashidi

Ghaderian

Sedaghat

et al. 2022

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“…However, according to the European Association of Nuclear Medicine guidelines ( 13 ) and Shen and Liu ( 3 ), severe hyperthyroidism with jaundice is a contraindication for 131 I therapy. Previous study has shown that the TH concentration could increase after 131 I therapy ( 14 ), because of the induction of acute radiation thyroiditis, which is associated with a large release of stored TH into the circulation, resulting in worsening of the symptoms of hyperthyroidism or even a thyroid storm ( 9 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of 131I with and without artificial liver support system in patients with Graves’ disease and severe liver dysfunction: A retrospective study

Rao

Wang²,

Ren³

et al. 2022

Front. Endocrinol.

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ObjectiveTreatment decision-making in Graves’ disease (GD) with severe liver dysfunction (LD) is a clinical challenge. This research was carried out to evaluate the effect of radioiodine (131I) with or without an artificial liver support system (ALSS) in GD patients with severe LD.MethodsIn total, 45 patients diagnosed with GD and severe LD were enrolled and allocated to two groups: patients treated with 131I alone (n=30) (Group A)and patients by a combination of 131I and ALSS (n=15)(Group B). Liver function, thyroid hormone concentrations, therapeutic efficacy, and the cost of treatment were compared between the two groups.ResultsThyroid hormone concentrations were lower 2 weeks after 131I treatment, but no deterioration in liver function was identified. There was no statistically significant difference in the treatment efficacy between the two groups. The hospital stay, total cost, and daily cost were lower in patients treated with 131I alone than in those treated with 131I and an ALSS (p<0.05).ConclusionThe key point of treating GD patients with severe LD is to control the GD.131I is recommended as an effective and safe and should be applied as soon as possible once the diagnosis is clarified; however, when used in combination with an ALSS, there was no substantial improvement in therapeutic efficacy.

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“…While after FT3, FT4, and TSH returned to normal levels, the situation of increased FT3 and FT4 appeared again ( 17 – 20 ). Drug reduction remission group ( n = 137): During ATD treatment, the clinical symptoms were relieved, and FT3, FT4, and TSH returned to normal levels ( 18 – 20 ). Normal ranges of hormones: FT3 (range 2.43–6.01 pmol/L), FT4 (range 9.01–19.50 pmol/L), TSH (range 0.35–4.94 uIU/mL), TRAb (range 0–1.5IU/L).…”

Section: Methodsmentioning

confidence: 99%

The relationship between atherosclerotic disease and relapse during ATD treatment

Zhu

Zhang²,

Zhao³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundClinical relapse is a potential risk for traditional antithyroid drug (ATD) treatment in hyperthyroid patients. Evidence suggests that atherosclerotic disease is closely associated with hyperthyroidism, while the relationship between atherosclerosis and relapse remains unclear.MethodsTwo hundred and twenty-five patients with GD who underwent ATD as their first treatment were studied; 88 and 137 patients were categorized as drug reduction relapse and drug reduction remission, respectively. Logistic regression was used to analyze risk factors of drug reduction relapse in patients with GD.ResultsDuring a median of 48 months followed up 88 patients who relapsed. According to multivariate analyses, atherosclerosis related diseases, FT4, goiter, and anxiety rating scores are independent risk factors for drug reduction. According to K-M survival analysis, patients with atherosclerosis related diseases, FT4 > 18.82 pmol/L, anxiety rating scores > 23, and gradation of goiter ≥ Grade II had a higher risk of relapse than those with lower levels. ROC analysis shown atherosclerosis related diseases significantly improved the predictive accuracy of relapse.ConclusionsAtherosclerotic disease is closely related to the relapse of hyperthyroidism, ATD treatment in hyperthyroid patients with atherosclerosis should be given more attention.

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¹³¹I therapy for 345 patients with refractory severe hyperthyroidism: Without antithyroid drug pretreatment

Abstract: The aim of this study is to evaluate the safety and long-term results of 131

Cited by 10 publications

References 13 publications

Effect of iodine-therapy on hyperthyroidism patients without pre-administration of anti-thyroid therapeutic options

Effect of iodine-therapy on hyperthyroidism patients without pre-administration of anti-thyroid therapeutic options

Effect of 131I with and without artificial liver support system in patients with Graves’ disease and severe liver dysfunction: A retrospective study

The relationship between atherosclerotic disease and relapse during ATD treatment

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131I therapy for 345 patients with refractory severe hyperthyroidism: Without antithyroid drug pretreatment

Abstract: The aim of this study is to evaluate the safety and long-term results of 131

Cited by 10 publications

References 13 publications

Effect of iodine-therapy on hyperthyroidism patients without pre-administration of anti-thyroid therapeutic options

Effect of iodine-therapy on hyperthyroidism patients without pre-administration of anti-thyroid therapeutic options

Effect of 131I with and without artificial liver support system in patients with Graves’ disease and severe liver dysfunction: A retrospective study

The relationship between atherosclerotic disease and relapse during ATD treatment

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¹³¹I therapy for 345 patients with refractory severe hyperthyroidism: Without antithyroid drug pretreatment