¹¹¹In-Labeled Glycoprotein Nonmetastatic b (GPNMB) Targeted Gemini Surfactant-Based Nanoparticles against Melanoma: In Vitro Characterization and in Vivo Evaluation in Melanoma Mouse Xenograft Model

Abstract

111 In-labeled glycoprotein non-metastatic b (GPNMB) targeted gemini surfactant-based nanoparticles against melanoma: In vitro characterization and in vivo evaluation in melanoma mouse xenograft model

New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation

“…Indium is mostly known for its applications in material science; on the contrary, its use in biochemistry and pharmaceuticals is very limited compared to gallium. It is used in radio imaging as 111 In [ 13 , 14 , 15 , 16 ] and 113m In [ 17 ], and few In(III) compounds have shown antimicrobial and cytotoxic efficacy [ 18 ]. Anyway, its chemical similarity to gallium and its enhanced metallic character constitutes a good start to investigate its coordination chemistry and eventual biomedicinal activity.…”

Production and Semi-Automated Processing of 89Zr Using a Commercially Available TRASIS MiniAiO Module

“…This is due to the favourable physical characteristics of the isotope which decays via positron emission (T 1/2 : 78.4 h, β + 22.7%, E β+max = 901 keV; average E β+max = 396 keV) [1,2] and electron capture (EC 77%, Eγ = 909 keV) to the stable yttrium-89 ( 89 Y). The longer half-life matches the need for large biomolecules such as antibodies, antibody fragments and nanoparticles which require prolonged circulation time in order to reach optimal target accumulation [3,4]. Furthermore, the β + branching ratio, average β + energy and short positron range (R ave = 1.23 mm) provide high spatial resolution and image quality of the 89 Zr PET probes [5].…”