¹¹ C-Methionine positron emission tomography-computed tomography in localization of methoxyisobutyl isonitrile negative ectopic parathyroid adenoma

Abstract

Primary hyperparathyroidism is caused by parathyroid adenomas in 85% of the cases. Since parathyroid adenomas are known for their ectopic location, presurgical localization of the suspected site of adenoma is desirable. However, current imaging modalities are not always successful in localizing ectopic parathyroid adenomas. The aim of this case report is to show that 11C-methionine positron emission tomography could accurately localize ectopic parathyroid adenomas in patients in whom conventional imaging had failed or is inconclusive.

Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment

“…Consequently, it has been linked to increased specificity for the parathyroid gland 45 . While our search did not identify any studies that used this technique to localize IPAs, Met PET/CT imaging can accurately identify other ectopic adenomas in those with negative sestamibi imaging 43,44 . Other radioisotopes are also being introduced.…”

“…Newer nuclear medicine imaging modalities, including 11 C‐methionine PET/CT, have been used in localizing parathyroid adenomas. 43 , 44 11 C‐methionine is a critical amino acid in the composition of pre‐pro‐PTH, the precursor for parathyroid hormone. Consequently, it has been linked to increased specificity for the parathyroid gland.…”

“…45 While our search did not identify any studies that used this technique to localize IPAs, Met PET/CT imaging can accurately identify other ectopic adenomas in those with negative sestamibi imaging. 43,44 Other radioisotopes are also being introduced. 18 F-fluorocholine has the benefit of a longer half-life compared to 11 C-methionine.…”