<sup>1</sup>H-NMR studies on the volume phase transition of DNA-modified pNipmam microgels

Hengsbach, Rebecca; Fink, Gerhard; Simon, Ulrich

doi:10.1039/d3sm01124k

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“…The preparation and characterization of P(NIPAm-co-NIPMAm)/chitosan core/shell nanohydrogels, capable of drug release at different temperatures and pH levels, were reported [51]. Recently, it was shown that DNA modification reduces the volume phase transition temperature of PNIPMAm microgels, which could be further lowered by salt [52].…”

Section: Poly(n-isopropylmethacrylamide)mentioning

confidence: 99%

Responsive Acrylamide-Based Hydrogels: Advances in Interpenetrating Polymer Structures

Hanyková,

Šťastná,

Krakovský

2024

Gels

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Hydrogels, composed of hydrophilic homopolymer or copolymer networks, have structures similar to natural living tissues, making them ideal for applications in drug delivery, tissue engineering, and biosensors. Since Wichterle and Lim first synthesized hydrogels in 1960, extensive research has led to various types with unique features. Responsive hydrogels, which undergo reversible structural changes when exposed to stimuli like temperature, pH, or specific molecules, are particularly promising. Temperature-sensitive hydrogels, which mimic biological processes, are the most studied, with poly(N-isopropylacrylamide) (PNIPAm) being prominent due to its lower critical solution temperature of around 32 °C. Additionally, pH-responsive hydrogels, composed of polyelectrolytes, change their structure in response to pH variations. Despite their potential, conventional hydrogels often lack mechanical strength. The double-network (DN) hydrogel approach, introduced by Gong in 2003, significantly enhanced mechanical properties, leading to innovations like shape-deformable DN hydrogels, organic/inorganic composites, and flexible display devices. These advancements highlight the potential of hydrogels in diverse fields requiring precise and adaptable material performance. In this review, we focus on advancements in the field of responsive acrylamide-based hydrogels with IPN structures, emphasizing the recent research on DN hydrogels.

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Section: Poly(n-isopropylmethacrylamide)mentioning

confidence: 99%

Responsive Acrylamide-Based Hydrogels: Advances in Interpenetrating Polymer Structures

Hanyková,

Šťastná,

Krakovský

2024

Gels

View full text Add to dashboard Cite

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¹H-NMR studies on the volume phase transition of DNA-modified pNipmam microgels

Abstract: DNA functionalized pNipmam microgels, which have recently been introduced, are examined at different concentrations of sodium chloride and in PBS solutions via temperature dependent 1H-NMR measurements and are compared to pure pNipmam microgels.

Cited by 1 publication

References 45 publications

Responsive Acrylamide-Based Hydrogels: Advances in Interpenetrating Polymer Structures

Responsive Acrylamide-Based Hydrogels: Advances in Interpenetrating Polymer Structures

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1H-NMR studies on the volume phase transition of DNA-modified pNipmam microgels

Abstract: DNA functionalized pNipmam microgels, which have recently been introduced, are examined at different concentrations of sodium chloride and in PBS solutions via temperature dependent 1H-NMR measurements and are compared to pure pNipmam microgels.

Cited by 1 publication

References 45 publications

Responsive Acrylamide-Based Hydrogels: Advances in Interpenetrating Polymer Structures

Responsive Acrylamide-Based Hydrogels: Advances in Interpenetrating Polymer Structures

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¹H-NMR studies on the volume phase transition of DNA-modified pNipmam microgels