<sup>1</sup>H‐MR spectroscopy characterization of the adipose tissue associated with colorectal tumor

Mosconi, Elisa; Minicozzi, Annamaria; Marzola, Pasquina; Cordiano, Claudio; Sbarbati, Andrea

doi:10.1002/jmri.24177

Cited by 12 publications

(17 citation statements)

References 26 publications

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“…A solution that should be investigated consists in designing a specific shaped voxel (prism‐like voxel for example, as mentioned previously). Nevertheless, the preliminary quantification results obtained on these spectra are consistent with ex vivo analysis (study performed on humans).…”

Section: Discussionsupporting

confidence: 84%

“…In inflammatory conditions and cancer areas, this wrapping fat can be infiltrated by the progressive inflammatory or tumoral lesions . It was suggested in 2014 by Mosconi et al that lipid tissues surrounding colorectal tumors could allow a further insight in the characterization of colorectal tumors. This study focused on MUFAs near the tumors and showed that the concentration of these fatty acids was increased, whereas fat located further away did not show this trend.…”

Section: Discussionmentioning

confidence: 99%

“…Performed at high magnetic fields (9.4 T) and with excellent magnetic field homogeneity, this technique demonstrated sufficient sensitivity to analyze the ex vivo metabolic profile of colonic mucosa by measuring signals corresponding to millimolar metabolite concentrations . Furthermore, ex vivo MRS has recently been used for the characterization of the adipose tissue associated with colorectal tumors . This study has shown the strong potential of MRS in the assessment of intestinal pathologies.…”

Section: Introductionmentioning

confidence: 99%

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In vivo MRS for the assessment of mouse colon using a dedicated endorectal coil: initial findings

et al. 2017

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Inflammatory bowel disease is a common group of inflammation conditions that can affect the colon and the rectum. These pathologies require a careful follow-up of patients to prevent the development of colorectal cancer. Currently, conventional endoscopy is used to depict alterations of the intestinal walls, and biopsies are performed on suspicious lesions for further analysis (histology). MRS enables the in vivo analysis of biochemical content of tissues (i.e. without removing any samples). Combined with dedicated endorectal coils (ERCs), MRS provides new ways of characterizing alterations of tissues. An MRS in vivo protocol was specifically set up on healthy mice and on mice chemically treated to induce colitis. Acquisitions were performed on a 4.7 T system using a linear volume birdcage coil for the transmission of the B magnetic field, and a dedicated ERC was used for signal reception. Colon-wall complex, lumen and visceral fat were assessed on healthy and treated mice with voxel sizes ranging from 0.125 μL to 2 μL while keeping acquisition times below 3 min. The acquired spectra show various biochemical contents such as α- and β-methylene but also glycerol backbone and diacyl. Choline was detected in tumoral regions. Visceral fat regions display a high lipid content with no water, whereas colon-wall complex exhibits both high lipid and high water contents. To the best of our knowledge, this is the first time that in vivo MRS using an ERC has been performed in the assessment of colon walls and surrounding structures. It provides keys for the in vivo characterization of small local suspicious lesions and offers complementary solutions to biopsies.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo MRS for the assessment of mouse colon using a dedicated endorectal coil: initial findings

et al. 2017

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“…AT and its FA content have also been related to tumor progression by Mosconi et al [76] , who analyzed VAT peri-tumoral fat composition in CRC patients at different tumor stages. The total content of MUFA in close proximity of, but not far from the tumor lesion, was found significantly increased in patients at higher tumor stage, especially stage IV.…”

Section: Adipose Tissue Inflammation Fatty Acid Profile and Colorectmentioning

confidence: 99%

Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

Conti¹,

Cornò²,

Scazzocchio³

et al. 2019

JCMT

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Excess adiposity, a worldwide-growing pathological condition, is now recognized as a main risk factor for most chronic diseases including colorectal cancer (CRC). Obese subjects show an increased cancer incidence with obesity representing an important indicator of survival, prognosis, recurrence and response to therapy. A lowgrade chronic inflammation of metabolically active tissues including the adipose tissue (AT), defined as metainflammation, is a main feature of obesity. Fatty acids (FA), the main AT components, are important modulators of inflammation, and the type of FA stored in AT critically affects tissue functions. Their profile within AT mirrors FA dietary intake but also depends on a metabolic control. Obesity, changes in the habitual diet, weight loss or pathological conditions like CRC influence FA profile of AT pointing to these molecules as important actors in AT dysfunction and meta-inflammation, that characterize metabolic diseases and may favor cancer development. Worth of note, diet is receiving growing attention as a main determinant in cancer prevention due to its capacity to modulate immune response and inflammation. Alterations in the balance between different families of FA may contribute to generate a pro-inflammatory profile with deleterious effects on metabolic and immune homeostasis at both local and systemic levels. This review focuses on FA as regulators of human AT inflammation discussing the role of obesity-, diet-, and weight loss-associated changes in FA profile in this process. The relevance of FA composition of AT in linking diet, obesity and CRC will be also reviewed.

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“…17 The composition of fatty acids in periprostatic tissue is altered in patients with aggressive prostate cancers, 18 the characterization of adipose tissue in close proximity to colorectal tumors showed an alteration of monounsaturated fatty acids related to the stage of the tumor. 19 …”

Section: Introductionmentioning

confidence: 99%

In vivo imaging techniques: a new era for histochemical analysis

et al. 2016

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In vivo imaging techniques can be integrated with classical histochemistry to create an actual histochemistry of water. In particular, Magnetic Resonance Imaging (MRI), an imaging technique primarily used as diagnostic tool in clinical/preclinical research, has excellent anatomical resolution, unlimited penetration depth and intrinsic soft tissue contrast. Thanks to the technological development, MRI is not only capable to provide morphological information but also and more interestingly functional, biophysical and molecular. In this paper we describe the main features of several advanced imaging techniques, such as MRI microscopy, Magnetic Resonance Spectroscopy, functional MRI, Diffusion Tensor Imaging and MRI with contrast agent as a useful support to classical histochemistry.

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¹H‐MR spectroscopy characterization of the adipose tissue associated with colorectal tumor

Abstract: Looking at the lipid tissue around a lesion through (1) H-MRS can return important information regarding its genesis and development.

Cited by 12 publications

References 26 publications

In vivo MRS for the assessment of mouse colon using a dedicated endorectal coil: initial findings

In vivo MRS for the assessment of mouse colon using a dedicated endorectal coil: initial findings

Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

In vivo imaging techniques: a new era for histochemical analysis

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1H‐MR spectroscopy characterization of the adipose tissue associated with colorectal tumor

Abstract: Looking at the lipid tissue around a lesion through (1) H-MRS can return important information regarding its genesis and development.

Cited by 12 publications

References 26 publications

In vivo MRS for the assessment of mouse colon using a dedicated endorectal coil: initial findings

In vivo MRS for the assessment of mouse colon using a dedicated endorectal coil: initial findings

Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

In vivo imaging techniques: a new era for histochemical analysis

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Product

Resources

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¹H‐MR spectroscopy characterization of the adipose tissue associated with colorectal tumor