¹H image‐guided localized ³¹P MR spectroscopy of human brain: Quantitative analysis of ³¹P MR spectra measured on volunteers and on intracranial tumor patients

Abstract

1H image-guided 31P MR spectra of normal human brain and of intracranial tumors have been analyzed quantitatively. Tumor types examined include prolactinoma, lymphoma, and various grade gliomas. The experimental signals were processed by means of a time-domain least-square fitting procedure, which yields the spectral parameters, as well as a prediction of the standard deviations. Significant spectral variations are observed within both populations of normal brain and of intracranial tumor 31P MR spectra. The metabolic ratios derived from the glioma 31P MR spectra and from corresponding uninfiltrated brain tissue do not differ significantly. Significant differences are, however, observed between the metabolic ratios of prolactinoma and uninfiltrated tissue 31P MR spectra. Alkaline pH values are found for the prolactinoma and the high-grade gliomas. Furthermore, spectral differences are observed between the patient's uninfiltrated tissue 31P MR spectra and those of an unmatched population of volunteers. This underscores the necessity for control measurements on the uninfiltrated tissue of the patient and for controls from a matched population of healthy individuals.

Quantitative 31P MRS of the normal adult human brain. Assessment of interindividual differences and ageing effects

“…The experimental protocol was identical to the one discussed in detail in Ref. 6. Repetition time applied between successive measurements was 3 s, causing partial saturation of the resonance lines.7 The "P MR signals were the average of 256 or 512 individual measurements.…”

Metabolic In Vivo Visualization of Pituitary Adenomas: a Systematic Review of Imaging Modalities

“…10,26,27 Pituitary adenomas exhibited distinct metabolic profiles compared to other intracranial pathology or normal surrounding tissue. Chernov et al investigated the role of 1 H MRS at 1.5T in the characterization of 56 masses.…”

Effect of altitude on brain intracellular pH and inorganic phosphate levels

“…Foremost among these would be multi-site, altitude-based studies of medical conditions in which alterations of brain pH and/or cerebral Pi have been reported, and therefore patients' altitude of residence could potentially impact their disorder's incidence, severity and prognosis. These include bipolar disorder (Kato et al, 1993; Hamakawa et al, 2004; Jensen et al, 2008; Shi et al, 2012b; Sikoglu et al, 2013), seizure disorder (Laxer et al, 1992), ischemic stroke (Hugg et al, 1992; Levine et al, 1992; Sappey-Marinier et al, 1992), brain tumors (Cadoux-Hudson et al, 1989; Segebarth et al, 1989; Hubesch et al, 1990; Arnold et al, 1991; Maintz et al, 2002), mitochondrial disorders (Barbiroli et al, 1993; Moller et al, 2002), congenital malformations (Barbiroli et al, 1993), neurodegenerative diseases (Martinelli et al, 2000; Moller et al, 2002; Mochel et al, 2012) and traumatic brain injury (Pettegrew et al, 1988; Lee et al, 2012). Changes in brain pH have also been found in normative processes such as healthy aging (Forester et al, 2010), and pregnancy and childbirth (Holdcroft et al, 2005).…”