Sunscreens: A comprehensive review with the application of nanotechnology

Chavda, Vivek P.; Acharya, D. R.; Hala, Vivek; Vora, Lalitkumar K.; Dawre, Shilpa

doi:10.1016/j.jddst.2023.104720

Cited by 22 publications

(19 citation statements)

References 193 publications

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“…The sun is a source of various forms of radiation, such as infrared, visible light, and UV radiation. This UV radiation comprises a spectrum between 10 and 400 nm, being the most interactive radiation with the skin due to its high energy and small wavelength, facilitating its permeation through the skin barrier [2]. UV light is important in natural processes, such as vitamin D production, which happens by its interaction with 7-dehydrocholesterol at the epidermis [16].…”

Section: Ultraviolet Radiation and Photoprotectionmentioning

confidence: 99%

“…Photoprotection encompasses a wide array of strategies designed to minimize the adverse effects of solar radiation on the skin. Among these, photoprotective formulations, such as sunscreens, have emerged as a key strategy in combating UV-induced damage [2].…”

Section: Ultraviolet Radiation and Photoprotectionmentioning

confidence: 99%

“…A suitable sunscreen formulation should allow (i) a proper incorporation of effective UV filters, (ii) chemical stability of the filters, (iii) overall product stability over time, and (iv) topical delivery of incorporated filters, which must remain on the skin surface and SC [2]. If the filters permeate through the skin, they can reach the dermis and enter the blood vessels, leading to systemic distribution and toxic effects.…”

Section: Liposomes As a Strategy For Ulraviolet Filter Deliverymentioning

confidence: 99%

“…Ultraviolet (UV) radiation is one of the main contributing factors for skin damage due to its ability to cross the ozone layer [1]. Sunburn, skin elasticity reduction, wrinkle formation related to premature aging, and cellular DNA damage (a determining factor for skin carcinogenesis) are the main damages caused by UV rays [2]. Thus, skin protection against this harmful radiation is mandatory to preserve skin health and avoid skin cancer.…”

Section: Introductionmentioning

confidence: 99%

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Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Miranda,

Cruz,

Girão

et al. 2024

Pharmaceutics

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Sunscreen products are essential for shielding the skin from ultraviolet (UV) radiation, a leading cause of skin cancer. While existing products serve this purpose, there is a growing need to enhance their efficacy while minimizing potential systemic absorption of UV filters and associated toxicological risks. Liposomal-based formulations have emerged as a promising approach to address these challenges and develop advanced photoprotective products. These vesicular systems offer versatility in carrying both hydrophilic and lipophilic UV filters, enabling the creation of broad-spectrum sunscreens. Moreover, their composition based on phospholipids, resembling that of the stratum corneum, facilitates adherence to the skin’s surface layers, thereby improving photoprotective efficacy. The research discussed in this review underscores the significant advantages of liposomes in photoprotection, including their ability to limit the systemic absorption of UV filters, enhance formulation stability, and augment photoprotective effects. However, despite these benefits, there remains a notable gap between the potential of liposomal systems and their utilization in sunscreen development. Consequently, this review emphasizes the importance of leveraging liposomes and related vesicular systems as innovative tools for crafting novel and more efficient photoprotective formulations.

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Section: Ultraviolet Radiation and Photoprotectionmentioning

confidence: 99%

Section: Ultraviolet Radiation and Photoprotectionmentioning

confidence: 99%

Section: Liposomes As a Strategy For Ulraviolet Filter Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Miranda,

Cruz,

Girão

et al. 2024

Pharmaceutics

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“…Inorganic nanoparticles are particularly not recommended to be employed in spray formulations, because their inhalation can lead to lung inflammation and microvascular dysfunction [ 1 , 15 ]. To overcome these hurdles, researchers have been investigating lipid-based nanoparticles as safer and biodegradable alternatives for encapsulating organic UV filters to benefit from the combined effects promoted by free organic UV filters and nanostructures [ 18 , 19 , 20 , 21 ]. For instance, a 2-fold increase in SPF was reported when 20% ( w / w ) of a lipid-based nanocarrier was added to a sunscreen formulation [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection

de Araújo,

Schneid,

Oliveira

et al. 2024

Pharmaceutics

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The topical use of sunscreens is recommended for avoiding the damaging effects of UV radiation. However, improvements are still needed in the existing products to enhance their photoprotection effectiveness and safety. This involves minimizing the use of chemical UV filters while providing enhanced and prolonged photoprotection. This work investigated novel sunscreen formulations and their UV protection effects by encapsulating Uvinul® A, Tinosorb® S, and Uvinul® T150 into nanostructured lipid carriers (NLCs) based on bacuri butter and raspberry seed oil. First, the impact of critical formulation and process parameters on NLCs’ particle size was evaluated using a 22 Face Centered Central Composite Design. Then, formulations were evaluated in terms of critical quality factors, in vitro skin permeation, and in vitro and in vivo photoprotection activities. The developed NLCs-containing formulations exhibited appropriate size (122–135 nm), PdI (<0.3), encapsulation efficiency (>90%), and drug content (>80%), which were preserved for at least 90 days under different stability conditions. Moreover, these NLCs-based formulations had equivalent skin permeation to emulsion-based controls, and the addition of NLCs into sunscreen cream bases in the optimum proportion of 20% (w/w) resulted in enhanced UVA and UVB photoprotection levels, despite a 10% reduction in the total filters content. Altogether, these results describe the application of nanoencapsulated organic UV filters in innovative sunscreen formulations to achieve superior photoprotection and cosmeceutical properties.

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Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

Fatima,

Almalki,

Khan

et al. 2024

Advanced Materials

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The quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli‐reactive nanosystems in biomedicine and outlines future development prospects.This article is protected by copyright. All rights reserved

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Sunscreens: A comprehensive review with the application of nanotechnology

Cited by 22 publications

References 193 publications

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection

Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

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