Sunscreen protection for lip mucosa: a review and update

Lundeen, R.Curtis; Langlais, Robert P.; Terézhalmy, Géza T.

doi:10.14219/jada.archive.1985.0157

Cited by 34 publications

(24 citation statements)

References 4 publications

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“…Individuals with suspected AC lesions were photographed and the classification was checked with regard to the degree of severity of the lesion, based on the classification proposed by the WHO (2005): a) Mild AC: rough, dry lips; b) Moderate AC: grooves or cracks perpendicular to the vermillion border (demarcation between the lip and adjacent skin); c) Severe AC: diffuse edema of the lip and effacement of the subcutaneous mycosis border 11 .…”

Section: Part Twomentioning

confidence: 99%

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The clinical prevalence of actinic cheilitis among community health agents from the regional V subprefecture of Fortaleza

Barreto

2017

RGO, Rev. Gaúch. Odontol.

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ObjectiveThe aim of this study was to evaluate clinically the prevalence of Actinic Cheilitis in community health agents from the Regional V subprefecture of Fortaleza. Methods The sample consisted of 333 community health workers exposed to the sun on a daily basis. The community health agents were evaluated through a questionnaire (with information about the individual, their occupations and habits) and a clinical examination in the first RESUMO ObjetivoAvaliar clinicamente a prevalência da queilite actínica em agentes comunitários de saúde na Regional V de Fortaleza. MétodosA amostra foi composta por 333 agentes comunitários de saúde. Os agentes comunitários de saúde, expostos diariamente ao sol, receberam esclarecimentos sobre a lesão, responderam um questionário (com informações pessoais, ocupacionais e habituais) na primeira etapa do estudo. Na segunda etapa do estudo, foram avaliados clinicamente, tiveram as lesões suspeitas fotografadas e classificadas quanto ao grau de severidade, acompanhadas e tratadas de acordo com a necessidade. As duas etapas foram realizadas por um, único, examinador. Os dados foram tabulados em planilha Excel e avaliados pelo teste G. ResultadosOs resultados mostraram, que a prevalência da queilite actínica foi significativamente associada à faixa etária, etnia/cor e uso de protetor labial. Foram encontrados 101 (30,3%) agentes comunitários de saúde com mucosa labial normal, 195 (58,5%) com alteração discreta de queilite actínica, 34 (10,2%) portadores de queilite actínica, moderada e em 3 (0,9%) identificou-se alteração intensa. ConclusãoO estudo concluiu que a prevalência da queilite actínica, é alta entre os agentes comunitários de saúde da Regional V de Fortaleza.Termos de indexação: Queilite actínica. Diagnóstico. Tratamento. The clinical prevalence of actinic cheilitis among community health agents from the regional V subprefecture of FortalezaA prevalência da queilite actínica em agentes comunitários de saúde

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Section: Part Twomentioning

confidence: 99%

“…In the beginning, the lips appear rough and dry, and afterwards perpendicular grooves or fissures appear at the vermillion border. In more advanced cases, the diffuse edema of the lip is more common as well as a loss at the vermillion border 11 .…”

Section: Introductionmentioning

confidence: 99%

The clinical prevalence of actinic cheilitis among community health agents from the regional V subprefecture of Fortaleza

Barreto

2017

RGO, Rev. Gaúch. Odontol.

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“…The lip vermillion constitutes a transition tissue, between oral mucosa and skin, where oral mucosal cells (e.g., keratinocytes, fibroblasts, mast cells and endothelial cells), are exposed to different types of environmental insults including ultraviolet (UV) sunlight (1) . Chronic exposure of the lip vermillion to sunlight results in several alterations at the epithelial and connective tissue compartments which are similar to those described in photodamaged skin (2)(3)(4) .…”

Section: Introductionmentioning

confidence: 99%

Single Exposure of Human Oral Mucosa Fibroblasts to Ultraviolet B Radiation Reduces Proliferation and Induces COX-2 Expression and Activation

Boza

Yefi²,

Rudolph³

et al. 2010

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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The lip vermillion constitutes a transition tissue, between oral mucosa and skin, where oral mucosal cells from epithelial and connective tissue compartments are exposed to ultraviolet (UV) sunlight. Fibroblasts are abundant resident cells of the connective tissue which are key regulators of extracellular matrix composition, as well as, epithelial and endothelial cell function. UVB light, an inherent component of sunlight, causes several alterations in skin fibroblasts, including premature senescence and increased cyclooxygenase (COX)-2 expression. To assess if UVB irradiation had similar effects on fibroblasts derived from human oral mucosa (HOM), primary cultures of HOM fibroblasts were irradiated with a single dose of 30 or 60 mJ/cm 2 of UVB light or shamirradiated. Fibroblast proliferation was assessed from 3 to 48 hrs after UVB-irradiation utilizing [ 3 H]-thymidine incorporation and MTT assays. In addition, COX-2 mRNA expression was detected by RT-PCR, and PGE 2 production was assessed using enzyme immunoassay from 0.5 to 24 hrs after UVBirradiation. The results showed a significant decrease in proliferation of UVB-irradiated HOM fibroblasts as compared to controls as measured by both [ 3 H]-thymidine incorporation and MTT assays (p<0.001). HOM fibroblasts had increased COX-2 mRNA expression at 0.5 and 12 hrs after irradiation, and PGE 2 production was elevated at 12 and 24 hrs post-irradiation as compared to controls (p<0.05). The results showed an inhibitory effect of a single dose of UVB irradiation on HOM fibroblast proliferation with an increase in COX-2 expression and activation. Therefore, photodamaged fibroblasts may play and important role in the pathogenesis of UV-induced lesions of the lip.

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“…As recently as 1985, the importance of UVR in the prevention of lip cancer was recognized and the addition of one further ‘S’, sunlight, to the five Ss that should be avoided, i.e. smoking, spirits, spices, sepsis and syphilis, was required [4]. Although lip cancer has been recognized as a form of oral cancer with a distinctive epidemiology [5], detailed investigations suggested that solar radiation is a major risk factor: notwithstanding the same importance of all risk factors in women and in men, the use of lip protection by women was responsible for the distinctive lower incidence of the disease in this particular population [6].…”

Section: Introductionmentioning

confidence: 99%

Lip Sun Protection Factor of a Lipstick Sunscreen

Gabard

Ademola²

2001

Dermatology

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Background and Objective: There is a well-documented need for effective human UVA and UVB photoprotection. Since there are important anatomical variations, the sun protection factor (SPF) of a lipstick sunscreen was measured on the anatomical site intended for use. Methods: The SPF tests were performed according to Federal US and European COLIPA guidelines. Prior to performing a test on the lip, the minimal erythemal dose (MED) of the unprotected back skin was determined. Subsequently, the sunscreen SPF was measured on the anatomical target site (lip). The evaluator was blinded with respect to scoring the SPF of each sunscreen treatment. Individual test sites were assigned to one of the following treatment conditions: (1) no treatment (MED of unprotected skin); (2) test formulation; (3) reference standard. Results: The MED on unprotected back skin was found to be 25% lower than on unprotected lip skin. The SPF of the lipstick sunscreen was measured 2 units lower than the SPF determined in the classical way on the back skin. Conclusion: It was hypothesized that the higher MED of the lower lip compared with back skin was due to the adaptation of this tissue to the continuous exposure to UV radiation.

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Sunscreen protection for lip mucosa: a review and update

Cited by 34 publications

References 4 publications

The clinical prevalence of actinic cheilitis among community health agents from the regional V subprefecture of Fortaleza

The clinical prevalence of actinic cheilitis among community health agents from the regional V subprefecture of Fortaleza

Single Exposure of Human Oral Mucosa Fibroblasts to Ultraviolet B Radiation Reduces Proliferation and Induces COX-2 Expression and Activation

Lip Sun Protection Factor of a Lipstick Sunscreen

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