Sunscreen applied at ≥ 2 mg cm<sup>−2</sup>during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐induced<scp>DNA</scp>damage and suppression of acquired immunity

Narbutt, Joanna; Philipsen, Peter Alshede; Harrison, Graham I.; Morgan, K; Lawrence, Karl P.; Baczynska, K.; Grys, Katarzyna; Rogowski-Tylman, Michał; Olejniczak-Staruch, Irmina; Tewari, Angela; Bell, Mike; O’Connor, Clare M.; Wulf, Hans Christian; Lesiak, Aleksandra; Young, Antony R.

doi:10.1111/bjd.17277

Cited by 29 publications

(44 citation statements)

References 59 publications

(82 reference statements)

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“…Few investigations have reported the erythemal reaction due to UV radiations at low doses on human skin . The results for erythema level are in accordance with a recent investigation, though using alternate technique, which concludes the reduction in erythema level by using sunscreen .…”

Section: Discussionsupporting

confidence: 85%

Photodamage and Photoprotection: An In vivo Approach Using Noninvasive Probes

Nawaz

Khan

Akhtar

et al. 2019

Photochem & Photobiology

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Solar radiations trigger the physiological alteration in skin which progress toward photoaging. Sunscreens are known to be effective against the photodamaging effects of sunlight. The purpose of this study was to evaluate the extent to which aging signs caused by real‐life sunlight exposure could be avoided by comparing various parameters between sun‐exposed and sun‐protected skin using noninvasive probes. Female volunteers (n = 11) after getting their consent were provided with marketed sunscreen product to apply onto their skin for 6 months. Measurements were scheduled every 15 days from the baseline reading for 6 months. Cutometer, Mexameter and Corneometer were used for evaluation of facial skin parameters. Clinical evaluations showed the effects of sunlight exposure on different skin parameters by comparing sun‐protected and unprotected skin, where Gross elasticity (R2), Net elasticity (R5), Viscoelasticity (R6) and Biological elasticity (R7) showed insignificant results, while Hydration, Melanin and Erythema showed significant results. Sun‐exposed skin presented 0.72%, 0.66%, 0.77%, 1.39%, 1.99%, 2.01% and 3.15% changes in R2, R5, R6 and R7, melanin, erythema and hydration, respectively, which were potentially prevented by sunscreen application. Premature aging is inhibited by following photoprotective regimen on routine basis, emphasizing the potential benefit of sunscreen against early aging signs.

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Section: Discussionsupporting

confidence: 85%

Photodamage and Photoprotection: An In vivo Approach Using Noninvasive Probes

Nawaz

Khan

Akhtar

et al. 2019

Photochem & Photobiology

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“…Fuller details of all aspects apart from vitamin D status are described in Narbutt et al . As previously reported, all nonvitamin D parameters were normally distributed, as are pre‐ and postholiday 25(OH)D 3 and the differences between them. The addition of the 25(OH)D 2 data (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…We have previously reported that sunscreen intervention in the same participants inhibited erythema. In contrast, there was marked erythema with discretionary sunscreen use …”

mentioning

confidence: 99%

Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

et al. 2019

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What's already known about this topic?• Action spectra (wavelength dependence) for erythema and the cutaneous formation of vitamin D overlap considerably in the ultraviolet (UV)B region.• Theoretically, sunscreens that inhibit erythema should also inhibit vitamin D synthesis.The study was approved by the Ethics Committee of the Medical University of Ł od z, Poland and done according to the Declaration of Helsinki. All participants (n = 79) gave written informed consent. Most were of Fitzpatrick skin type (FST) II and III. 32 The group demographics and study locations are summarized in Tables 1 and 2. Briefly, three groups of holidaymakers from Ł od z, Poland, spent a week during March

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“…Sunscreen protection varies according to the thickness and distribution of application, sun protection factor, and decay in effectiveness over time. Optimal sunscreen use (at 2 mg/cm 2 ) has been shown to prevent solar UVR immunosuppression, as measured by contact hypersensitivity responses (Narbutt et al, 2018). There is currently no validated method for correcting UVR exposure for sunscreen use based on questionnaire-derived data.…”

Section: Uvr and Response To Immunizationmentioning

confidence: 99%

Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity Study

Swaminathan

Harrison

Ketheesan

et al. 2019

Journal of Investigative Dermatology

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Animal and human studies show that exposure to solar-simulated UVR is immunomodulatory. Human studies that used natural sun exposure and controlled for confounding are rare. We immunized 217 healthy adults (age range ¼ 18e40 years) with a T-celledependent antigen, keyhole limpet hemocyanin, and measured personal clothing-adjusted UVR exposure (for 5 days before and after immunization), lifetime cumulative UVR exposure, serum 25-hydroxyvitamin D concentration at immunization, and potential confounding factors. We tested cellular and humoral immune responses in relation to UVR exposure. The delayed-type hypersensitivity response to keyhole limpet hemocyanin recall challenge was lower in individuals with higher personal clothing-adjusted UVR exposure on the day before immunization (P ¼ 0.015) and during intervals spanning the day before to 2e3 days after immunization. There was an incremental increase in T helper type 17 cells (as a proportion of CD4 þ T cells) from preimmunization to postimmunization in the high, compared with the low, personal clothing-adjusted UVR exposure group (0.31% vs. e0.39%, P ¼ 0.004). Keyhole limpet hemocyaninspecific antibody titers were not associated with acute or cumulative UVR exposure or serum 25hydroxyvitamin D levels. Higher UVR exposure at antigen sensitization was associated with a reduced delayed-type hypersensitivity response and altered T helper type 17 kinetics. This has implications for the effectiveness of vaccinations and susceptibility to infections that rely on cell-mediated immune responses.

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Sunscreen applied at ≥ 2 mg cm⁻²during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐inducedDNAdamage and suppression of acquired immunity

Cited by 29 publications

References 59 publications

Photodamage and Photoprotection: An In vivo Approach Using Noninvasive Probes

Photodamage and Photoprotection: An In vivo Approach Using Noninvasive Probes

Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity Study

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Sunscreen applied at ≥ 2 mg cm−2during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐inducedDNAdamage and suppression of acquired immunity

Cited by 29 publications

References 59 publications

Photodamage and Photoprotection: An In vivo Approach Using Noninvasive Probes

Photodamage and Photoprotection: An In vivo Approach Using Noninvasive Probes

Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity Study

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Sunscreen applied at ≥ 2 mg cm⁻²during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐inducedDNAdamage and suppression of acquired immunity