Sunlight, tanning booths, and vitamin D

Lim, Henry W.; Gilchrest, Barbara A.; Cooper, Kevin D.; Bischoff‐Ferrari, Heike A.; Rigel, Darrell S.; Cyr, W. Howard; Miller, Sharon A.; DeLeo, Vincent A.; Lee, Tim K.; Demko, Catherine A.; Weinstock, Martin A.; Young, Antony R.; Edwards, Laura Saul; Johnson, Timothy M.; Stone, Stephen

doi:10.1016/j.jaad.2005.03.015

Cited by 78 publications

(65 citation statements)

References 78 publications

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“…Sunlamp use is controversial (29), but was also quite rare in the youngest age group in this study. There was an inverse association, but it was not statistically significant for either age 10 to 19 or age 20 to 29.…”

Section: Discussionmentioning

confidence: 56%

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Vitamin D and Reduced Risk of Breast Cancer: A Population-Based Case-Control Study

Knight

Lesosky²,

Barnett³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

151

141

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Background: Vitamin D, antiproliferative and proapoptotic in breast cancer cell lines, can reduce the development of mammary tumors in carcinogen-exposed rats. Current evidence in humans is limited with some suggestion that vitamin D -related factors may reduce the risk of breast cancer. We conducted a population-based case-control study to assess the evidence for a relationship between sources of vitamin D and breast cancer risk. Methods: Women with newly diagnosed invasive breast cancer were identified from the Ontario Cancer Registry. Women without breast cancer were identified through randomly selected residential telephone numbers. Telephone interviews were completed for 972 cases and 1,135 controls. Odds ratios (OR) and 95% confidence intervals (CI) for vitamin D -related variables were estimated using unconditional logistic regression with adjustment for potential confounders.

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Section: Discussionmentioning

confidence: 56%

“…However, in truth, a recommendation of moderation may be more achievable than compete avoidance (29,30). Relatively short sun exposure time will maximize vitamin D generation, although the amount of vitamin D produced in a given time depends on the degree of skin coverage and skin color.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Reduced Risk of Breast Cancer: A Population-Based Case-Control Study

Knight

Lesosky²,

Barnett³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

151

141

View full text Add to dashboard Cite

show abstract

“…Finally, epidemiologic studies by some investigators found that melanoma patients do better if exposed to solar radiation after removal of the tumor, an indirect indication of a beneficial role for vitamin D metabolites during disease progression [134]. However, other investigators have questioned this correlation [135]. Nevertheless, there is sufficient experimental evidence for the use of vitamin D3 or its analogs in melanoma therapy.…”

Section: Glucocorticoids Receptorsmentioning

confidence: 99%

Melanocyte Receptors: Clinical Implications and Therapeutic Relevance

Carlson

Linette

Aplin

et al. 2007

Dermatologic Clinics

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Melanocytes are an intraepidermal population of dendritic cells responsible for the production of melanin, a pigment that varies from yellow to brown to black pigment that after transfer to neighboring keratinocytes acts both as an endogenous screen and a buffering system against harmful ultraviolet (UV) wavelengths in sunlight [1]. Skin pigmentation has both individual and societal implications. The cosmetic desire for increased pigmentation (tanning) has resulted in many deleterious alterations including hastened skin ageing with wrinkles and poikiloderma and an increase in lentigines, melanocytic nevi, and melanoma. Focal or widespread loss of normal pigmentation not only renders individuals extraordinarily vulnerable to the harmful effects of sunlight (eg, increased risk of skin cancer in albinism), but it can also result in severe emotional stress and, in some societies, ostracism and discrimination (eg, vitiligo).Melanocytes are derived from the neural crest and are located along the basal layer of the epidermis and within the hair follicle, predominately the basal layer of the hair bulb matrix [1,2]. By the 50th day of intrauterine life, melanocytes can be detected in the epidermis; their migration to the epidermis and survival is dependent on receptor tyrosine kinase (RTK) c-Kit and its ligand stem cell factor (SCF) within the epidermis [3,4]. Mutations of the c-Kit gene lead to patches of hypopigmentation caused by lack of melanocyte migration, termed piebaldism [5]. Another important signaling molecule in melanocyte migration and development is Wnt5a, which signals via the Frizzled-5 receptor [6]. Overexpression of Wnt5a/ Frizzled is found in melanomas and associated with increased cell motility and invasiveness [7,8].Skin keratinocytes obtain melanin pigment from melanocytes, and keratinocytes provide the necessary microenvironment for melanocyte survival, proliferation, differentiation, and migration via production of ligands that interact with melanocyte receptors [1,[9][10][11] NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript epidermal melanin unit denotes the symbiotic relationship between one melanocyte transporting melanin via its dendritic processes to approximately 36 keratinocytes [10]. Melanocytes are located on the basement membrane among basal keratinocytes at ratio of 1 melanocyte per 5 basal keratinocytes in hematoxylin and eosin-stained histologic sections. This balance is maintained through regulated induction of melanocyte division. During childhood as the skin surface expands, throughout adulthood to maintain melanocyte numbers, and in response to exposure to sunlight or skin wounding, melanocytes are stimulated to proliferate at a low rate. Melanocyte proliferation entails uncoupling from keratinocytes, loss of their dendrites, cell division, migration along the basement membrane, then recoupling with keratinocytes to form the epidermal melanin unit. Keratinocytes regulate melanocyte growth and expression of melanocyte cell surface receptors via cell adhes...

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“…[22] Tanning beds are an alternative to sun exposure, as long as regulations are followed to guarantee the users health safety. The user in this case should also be informed that tanning beds are for tanning purposes only, [23] since just some tanning beds can provide vitamin D, not always being the case. [24] 2.1 Examples of varies of UV protection factors in textiles and how they can be used…”

Section: Uv Protection Factor In Clothes For Tattooing Purposesmentioning

confidence: 99%

Solar Wear Tattoo – Combining Functional Materials Taking Advantage of Different UPF of Textiles, to Create Healthier Tattooing Alternatives

Mendes

Kong²

2017

MATEC Web Conf.

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Abstract. Tattooing process can be a painful experience whether achieving a permanent or temporary body art on skin, and there can be horrible consequences. By taking advantage of UV protection factor variables of fashion clothing materials, it is possible to create this kind of body art in a much healthier way. The material performance is key, besides UPF materials that relies on the material behaviour when combined, layer sequence of these materials used for the desired function is equally as important, if not, even more important so. When properly combined in the correct order, making use of the right technology it may be possible to test different combinations. The advantages are, besides creating a temporary tattoo, that the user can benefit from moderate sun bathing advantages, that can provide the desired body art design on skin and the sunbathing health benefits. All of this can only be possible with a deep understanding of the UV protection factor of fashion materials, and how it can be tested and used in the manufacturing process for the desired function.

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Sunlight, tanning booths, and vitamin D

Cited by 78 publications

References 78 publications

Vitamin D and Reduced Risk of Breast Cancer: A Population-Based Case-Control Study

Vitamin D and Reduced Risk of Breast Cancer: A Population-Based Case-Control Study

Melanocyte Receptors: Clinical Implications and Therapeutic Relevance

Solar Wear Tattoo – Combining Functional Materials Taking Advantage of Different UPF of Textiles, to Create Healthier Tattooing Alternatives

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