Sunlight-induced genotoxicity and damage in keratin structures decrease tadpole performance

Santos, Caroline Peripolli dos; Londero, James Eduardo Lago; Santos, Maurício Beux dos; Feltrin, Rayana dos Santos; Loebens, Luíza; Moura, Livia Bataioli; Cechin, Sônia Zanini; Schuch, André Passaglia

doi:10.1016/j.jphotobiol.2018.03.013

Cited by 15 publications

(6 citation statements)

References 35 publications

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“…decreased locomotion was an observed trend in our results) and behaviour (i.e. increased sheltering) if energy requirements for responding to UVR are highly energy demanding (Araújo et al, 2021; dos Santos et al, 2018; Pulgar et al, 2015; Schuch et al, 2015). The sublethal effects of impaired individual performance, DNA damage and increased oxidative stress may have consequences at the ecosystem level, especially if the effects of UVR are exacerbated by other environmental stressors (e.g.…”

Section: Discussionsupporting

confidence: 61%

Sublethal consequences of ultraviolet radiation exposure on vertebrates: Synthesis through meta‐analysis

Downie

Cramp

et al. 2023

Global Change Biology

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Ultraviolet radiation (UVR) from the sun is a natural daytime stressor for vertebrates in both terrestrial and aquatic ecosystems. UVR effects on the physiology of vertebrates manifest at the cellular level, but have bottom‐up effects at the tissue level and on whole‐animal performance and behaviours. Climate change and habitat loss (i.e. loss of shelter from UVR) could interact with and exacerbate the genotoxic and cytotoxic impacts of UVR on vertebrates. Therefore, it is important to understand the range and magnitude of effects that UVR can have on a diversity of physiological metrics, and how these may be shaped by taxa, life stage or geographical range in the major vertebrate groups. Using a meta‐analytical approach, we used 895 observations from 47 different vertebrate species (fish, amphibian, reptile and bird), and 51 physiological metrics (i.e. cellular, tissue and whole‐animal metrics), across 73 independent studies, to elucidate the general patterns of UVR effects on vertebrate physiology. We found that while UVR's impacts on vertebrates are generally negative, fish and amphibians were the most susceptible taxa, adult and larvae were the most susceptible life stages, and animals inhabiting temperate and tropical latitudes were the most susceptible to UVR stress. This information is critical to further our understanding of the adaptive capacity of vulnerable taxon to UVR stress, and the wide‐spread sublethal physiological effects of UVR on vertebrates, such as DNA damage and cellular stress, which may translate up to impaired growth and locomotor performance. These impairments to individual fitness highlighted by our study may potentially cause disruptions at the ecosystem scale, especially if the effects of this pervasive diurnal stressor are exacerbated by climate change and reduced refuge due to habitat loss and degradation. Therefore, conservation of habitats that provide refuge to UVR stress will be critical to mitigate stress from this pervasive daytime stressor.

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Section: Discussionsupporting

confidence: 61%

Sublethal consequences of ultraviolet radiation exposure on vertebrates: Synthesis through meta‐analysis

Downie

Cramp

et al. 2023

Global Change Biology

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“…For example, UVR‐induced DNA lesions can block transcription and replication, which signal cellular senescence, apoptosis or autophagy (Batista et al, 2009; Schuch & Menck, 2010). In turn, epidermal cell death can cause wounds and scarring that can impact upon a range of crucial functions later in life, including osmoregulation, camouflage and susceptibility to pathogens of the skin (Biniek et al, 2012; Lundsgaard, 2022; Santos et al, 2018; Van Rooij et al, 2015). If cell death is not executed in time, UVR‐induced DNA lesions can cause mutations that lead to tumours and other malformations (Londero et al, 2019).…”

Section: Ultraviolet Radiation and Amphibians: A Case Studymentioning

confidence: 99%

“…If early stage UVR exposure alters the development of skin‐based defenses in juvenile amphibians, this may provide a mechanistic link between UVR exposure and some disease‐related declines. While this hypothesis has not been investigated, the alteration of metamorphic epithelial patterning and integrity following larval UVR exposure suggests persistent UV‐induced changes to skin morphology are highly plausible (Londero et al, 2019; Lundsgaard, 2022; Santos et al, 2018).…”

Section: Ultraviolet Radiation and Amphibians: A Case Studymentioning

confidence: 99%

Carryover effects from environmental change in early life: An overlooked driver of the amphibian extinction crisis?

Lundsgaard

Hird

Doody

et al. 2023

Global Change Biology

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Ecological carryover effects, or "the delayed effects of environment" on organism performance and fitness, are common across taxa and present a growing challenge for conservation biology in the face of rapid environmental change (O'Connor & Cooke, 2015; Cooke et al., 2021). As climatic fluctuations increase in magnitude and frequency (Solomon et al., 2007), organisms face an exacerbated risk of exposure to environmental stressors throughout development that may elicit detrimental carryover effects (Alton & Franklin, 2017;O 'Connor & Cooke, 2015;Thomas et al., 2004). Unfortunately, the latent nature of carryover effects and the long temporal scales over

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“…Increased UVBR is hypothesized to influence amphibian populations through direct impacts on eggs and larvae as these life stages are often diurnal and typically laid during spring and summer when UVBR levels are highest [ 26 ]. UVBR exposure causes a range of sublethal and lethal effects in amphibian embryos and larvae [ 27 ] which occur primarily through the formation of cyclobutane pyrimidine dimer (CPD) photoproducts in DNA, which are repaired largely via PER in amphibians [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Temperature causes species-specific responses to UV-induced DNA damage in amphibian larvae

2022

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Anthropogenic ozone depletion has led to a 2–5% increase in ultraviolet B radiation (UVBR) levels reaching the earth's surface. Exposure to UVBR causes harmful DNA damage in amphibians, but this is minimized by DNA repair enzymes such as thermally sensitive cyclobutane pyrimidine dimer (CPD)-photolyase, with cool temperatures slowing repair rates. It is unknown whether amphibian species differ in the repair response to a given dose of UVBR across temperatures. We reared larvae of three species ( Limnodynastes peronii , Limnodynastes tasmaniensis and Platyplectrum ornatum ) at 25°C and acutely exposed them to 80 µW cm −2 UVBR for 2 h at either 20°C or 30°C. UVBR-mediated DNA damage was measured as larvae repaired damage in photoreactive light at their exposure temperatures. Cool temperatures increased DNA damage in two species and slowed DNA repair rate in P. ornatum . The magnitude of DNA damage incurred from UVBR was species-specific. Platyplectrum ornatum had the lowest CPDs and DNA repair rates, and the depressive effects of low temperature on photorepair were greater in L. tasmaniensis . Considering the susceptibility of most aquatic organisms to UVBR, this research highlighted a need to consider the complexity of species-specific physiology when forecasting the influence of changing UVBR and temperature in aquatic ecosystems.

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Sunlight-induced genotoxicity and damage in keratin structures decrease tadpole performance

Cited by 15 publications

References 35 publications

Sublethal consequences of ultraviolet radiation exposure on vertebrates: Synthesis through meta‐analysis

Sublethal consequences of ultraviolet radiation exposure on vertebrates: Synthesis through meta‐analysis

Carryover effects from environmental change in early life: An overlooked driver of the amphibian extinction crisis?

Temperature causes species-specific responses to UV-induced DNA damage in amphibian larvae

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