Sunlight Exposure, Pigmentary Factors, and Risk of Nonmelanocytic Skin Cancer

Gallagher, Richard P.; Hill, Gerry B.; Bajdik, Chris; Fincham, Shirley; Coldman, Andrew J.; McLean, David I.; Threlfall, William J.

doi:10.1001/archderm.1995.01690140041006

Cited by 409 publications

(138 citation statements)

References 18 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…Skin type I (always burns, never tans), red or pale hair, and blue or green eyes have been shown to be risk factors for the development of basal cell carcinoma, with an estimated odds ratio of 1.6 [93]. Advance of basal cell carcinoma is reported to be more frequent after freckling in childhood and also after frequent or severe sunburn in childhood [94,95]. This is in contrast to a history of sunburn as an adult, which does not seem to be associated with the development of basal cell carcinoma [95].…”

Section: Applicationsmentioning

confidence: 99%

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Rai¹,

Pandey²,

Rai³

2017

Nano Reviews & Experiments

198

View full text Add to dashboard Cite

Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of edge activator, phospholipids, ethanol, and sodium cholate and are applied in a non-occlusive manner. Areas covered: This article covers information such as merits/demerits of transfersomes, regulatory aspects of materials used in preparation, different methods of preparation, mechanism of action, review of clinical investigations performed, marketed preparations available, research reports, and patent reports related to transfersomes. Expert opinion: Research over the past few years has provided a better understanding of transfersomal permeation of therapeutic agents across stratum corneum barrier. Transfersomes provides an essential feature of their application to variety of compositions in order to optimize the permeability of a range of therapeutic molecules. This is evidenced by the fact that there are several Transfersome products being processed in advanced clinical trials. It is noteworthy that a number of Transfersome products for dermal and transdermal delivery will gain a global market success in near future.

show abstract

Section: Applicationsmentioning

confidence: 99%

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Rai¹,

Pandey²,

Rai³

2017

Nano Reviews & Experiments

198

View full text Add to dashboard Cite

show abstract

“…En los tumores en que se sospeche invasión a estructuras profundas como el cartílago, el hueso o el globo ocular, se recomienda realizar una tomografía axial computarizada o una resonancia nuclear magnética que permita determinar la extensión del carcinoma, ya que el crecimiento sigue zonas de menor resistencia y se disemina siguiendo pericondrio, periostio, fascia, lo que explica la dificultad para tratar los CBC que recidivan situados en la nariz, la oreja, el párpado y el cuero cabelludo (23,24).…”

Section: Diagnóstico Y Evaluación Del Cbcunclassified

“…En general, los carcinomas basocelulares desarrollados en la cabeza y el cuello tienen mayor probabilidad de recurrir que los localizados en el tronco y las extremidades (23,24).…”

Section: Factores De Riesgo Clínicosunclassified

See 1 more Smart Citation

Cáncer de piel: Una realidad cotidianamente ignorada.

Piñeros

Osorio

2017

carta comunitaria

View full text Add to dashboard Cite

INTRODUCCIÓNLa piel es el mayor órgano del cuerpo humano. Ocupa aproximadamente 2 m 2 y su espesor varía entre los 0,5 mm (en los párpados) y los 4 mm (en el talón). Su peso aproximado es de 5 kg. Actúa como barrera protectora que aísla al organismo del medio que lo rodea, protegiéndolo y contribuyendo a mantener íntegras sus estructuras, al tiempo que actúa como sistema de comunicación con el entorno.Dado el tamaño y características de este órgano, podemos afirmar que el cáncer de piel es la patología tumoral maligna más común, especialmente en sujetos de raza blanca como lo veremos más adelante (1, 2).

show abstract

“…The most commonly diagnosed cancer in the Caucasian population is basal cell carcinoma (BCC), a non-melanoma skin cancer (NMSC) (1,2). UV radiation is considered the most critical risk factor for inducing BCC carcinogenesis (2,3).…”

Section: Introductionmentioning

confidence: 99%

E6 and E7 of human papillomavirus type 18 and UVB irradiation corporately regulate interleukin‐6 and interleukin‐8 expressions in basal cell carcinoma

Hsiao

Yang

et al. 2013

Experimental Dermatology

View full text Add to dashboard Cite

The lack of a human papillomavirus (HPV)-infected skin cancer cell line has hampered the investigation of the interaction of UV and HPV in skin carcinogenesis. We identified a human basal cell carcinoma (BCC-1/KMC) cell line integrated with E6 and E7 genes of high-risk HPV type 18 and demonstrated that repression of E6 and E7 results in proliferation inhibition. Sublethal ultraviolet-B (UVB) irradiation induced the expressions of interleukin-6 (IL-6) and interleukin-8 (IL-8), as well as viral E6 and E7 genes, in BCC-1/KMC cells. When E6 and E7 expressions were inhibited, IL-6/IL-8 expressions were repressed. Furthermore, IL-6/IL-8 remained inducible by UVB irradiation when E6 and E7 were inhibited. These results indicated that IL-6 and IL-8 can be upregulated by viral E6 and E7 proteins without UVB irradiation. Moreover, chronic exposure to UVB upregulates IL-6 and IL-8 when E6/E7 is induced by UVB.

show abstract

Sunlight Exposure, Pigmentary Factors, and Risk of Nonmelanocytic Skin Cancer

Cited by 409 publications

References 18 publications

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Cáncer de piel: Una realidad cotidianamente ignorada.

E6 and E7 of human papillomavirus type 18 and UVB irradiation corporately regulate interleukin‐6 and interleukin‐8 expressions in basal cell carcinoma

Contact Info

Product

Resources

About