Sunitinib Produces Neuroprotective Effect Via Inhibiting Nitric Oxide Overproduction

Abstract

Sunitinib exerts its neuroprotective effects by inhibiting NO overproduction, possibly via the inhibition of nNOS activity and the decrease in nNOS expression.

Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy?

“…However, we did not address the possibility that sunitinib might have resulted in the absence of seizures by modifying or reducing the impact of the initial insult (status epilepticus) via its anti‐VEGF property or other mechanisms. Although there is some evidence that sunitinib may have a partial neuroprotective mechanism through inhibition of nitric oxide production (Cui et al, 2014), there is currently no evidence from the literature, to our knowledge, that sunitinib has any anti‐convulsant role that may have allowed to modulate the initial status epilepticus. However, only studies with EEG recordings performed during and after the status epilepticus could exclude this possibility with certainty.…”

Fucoxanthin prevents H2O2-induced neuronal apoptosis via concurrently activating the PI3-K/Akt cascade and inhibiting the ERK pathway

“…[22,23] Briefly, 10 μl of MTT solution (5 mg   ml –1 ) was added to each well after treatment. Plates were incubated at 37°C for 4 h in a humidified incubator.…”

Phytanic acid induces Neuro2a cell death via histone deacetylase activation and mitochondrial dysfunction

“…3A, B). Phytanic acid treatment also increased the number of brightly stained nuclei with condensed chromatin, which is generally used as apoptotic marker (Cui et al, 2014), although these cells were still negative for PI staining (Fig. 3A, arrows).…”